C–H activation-initiated spiroannulation reactions and their applications in the synthesis of spirocyclic compounds

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(12), С. 2324 - 2338

Опубликована: Янв. 1, 2024

This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications construction of structurally diverse biologically valuable spirocyclic scaffolds.

Язык: Английский

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Microwave assisted N-Directed Pd-Catalyzed Direct ortho-Acyloxylation, and ortho-Hydroxylation of benzo[b][1,4]oxazin- 2-ones via C-H Activation

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134552 - 134552

Опубликована: Фев. 1, 2025

Язык: Английский

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Synthesis of Polycyclic Heteroarenes via Rh(III)-Catalyzed Twofold C-H Activation of 3-Aryl-2H-benzo[b][1,4]oxazines and Annulation with α-Diazo-β-ketoesters

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

An efficient Rh(III)-catalyzed annulation between 3-aryl-2H-benzo[b][1,4]oxazines and α-diazo-β-ketoesters was developed, affording a series of polycyclic heteroarenes in moderate to excellent yields with good functional group compatibility. The procedure featured high efficiency, redox neutrality, twofold ortho-C-H activation, dual [4 + 2] annulation. Moreover, several important intermediates products have been isolated as powerful evidence for the proposed reaction mechanism.

Язык: Английский

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Annulations involving p-benzoquinones: stereoselective synthesis of fused, spiro and bridged molecules

New Journal of Chemistry, Год журнала: 2024, Номер 48(18), С. 8243 - 8276

Опубликована: Янв. 1, 2024

The present review summarizes the recent advances (2018–2023) in stereoselective annulation involving p -benzoquinones for construction of fused, spiro and bridged/cage frameworks.

Язык: Английский

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Synthesis of Spiropyrans via Rh(III)-Catalyzed [3+3] Cyclization of 3-Aryl-2H-1,4-benzoxazine and Diazonaphthalene-2H-ones

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(7), С. 2223 - 2223

Опубликована: Янв. 1, 2024

Язык: Английский

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Rhodium‐Catalyzed Regioselective C7_Ar‐Functionalization of Tryptophan with Quinones and its Late Stage Peptide Exemplification

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(12)

Опубликована: Ноя. 10, 2023

Abstract Pivaloyl‐directed Rh(III)‐catalyzed regioselective C7 Ar ‐H functionalization of protected tryptophans were accomplished with 1,4‐benzoquinones, furnishing a series quinone‐appended tryptophan‐based unnatural amino acids in high yields. Further, the late stage on tryptophan‐containing dipeptides was achieved 1,4‐benzoquinones moderate reactivity.

Язык: Английский

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Synthesis of spiropyrans via Ru(ii)-catalyzed coupling of 3-aryl-2H-benzo[b][1,4]oxazines with benzoquinones

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 22(5), С. 998 - 1009

Опубликована: Дек. 26, 2023

An efficient Ru( ii )-catalyzed C–H activation-based spiroannulation of benzoxazines with easily available benzoquinone and N -sulfonyl quinone monoimine has been realized, providing a straightforward strategy to access NH-containing spiropyrans.

Язык: Английский

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Six-membered ring systems: With O and/or S atoms

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 421 - 484

Опубликована: Янв. 1, 2024

Язык: Английский

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