Intermediates in Mechanochemical Reactions

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(14)

Опубликована: Янв. 5, 2024

Abstract Mechanochemical reactions offer methodological and environmental advantages for chemical synthesis, constantly attracting attention within the scientific community. Besides unmistakable sustainability advantages, conditions under which mechanochemical occur, namely solventless conditions, sometimes facilitate isolation of otherwise labile or inaccessible products. Despite these limited knowledge exists regarding mechanisms types intermediates involved. Nevertheless, in an expanding number cases, ex situ monitoring techniques have allowed observation, characterization, reaction transformations. In this Minireview, we present a series examples reactive been detected spanning organic, organometallic, inorganic, materials chemistry. Many were stabilized by non‐covalent interactions, played pivotal role guiding We believe that uncovering understanding such instances, growing mechanochemistry community could find novel opportunities catalysis discover new while achieving simplification design.

Язык: Английский

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The good, the bad, and the ugly of metals as antimicrobials

BioMetals, Год журнала: 2023, Номер 37(3), С. 545 - 559

Опубликована: Дек. 19, 2023

Abstract We are now moving into the antimicrobial resistance (AMR) era where more antibiotic resistant bacteria majority, a problem brought on by both misuse and over use of antibiotics. Unfortunately, development pipeline dwindled away past decades as they not very profitable compounds for companies to develop. Regardless researchers decade have made strides explore alternative options out this we see revisiting historical infection control agents such toxic metals. From field research exploring efficacy metal ions complexes antimicrobials. Such antimicrobials delivered in variety forms from salts, alloys, complexes, organometallic compounds, based nanomaterials gives us broad term metalloantimicrobials. many effective formulations applied various applications using metals that against drug strains. The purpose document here is step aside begin conversation issues microbes. This critical opinion mini-review no way aims be comprehensive. goal understand benefits metalloantimicrobials, but also consider strongly disadvantages metals, what potential consequences overuse. need conscious issues, entire system affect through OneHealth vision.

Язык: Английский

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Organolanthanide Single‐Molecule Magnets with Heterocyclic Ligands

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(38)

Опубликована: Июль 2, 2024

Lanthanide (Ln) based mononuclear single-molecule magnets (SMMs) provide probably the finest ligand regulation model for magnetic property. Recently, development of such SMMs has witnessed a fast transition from coordination to organometallic complexes because latter provides fertile, yet not fully excavated soil SMMs. Especially those with heterocyclic ligands have shown potential reach higher blocking temperature. In this minireview, we give an overview design principle and highlight "shining stars" organolanthanide on ring sizes ligands, analysing how electronic structures stiffness subsequently formed molecules affect dynamic magnetism Finally, envisaged future Ln-SMMs.

Язык: Английский

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Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 13, 2024

The inappropriate and inconsistent use of antibiotics in combating multidrug-resistant bacteria exacerbates their drug resistance through a few distinct pathways. Firstly, these can accumulate multiple genes, each conferring to specific drug, within single cell. This accumulation usually takes place on plasmids (R). Secondly, multidrug arise from the heightened expression genes encoding efflux pumps, which expel broad spectrum drugs bacterial cells. Additionally, also eliminate or destroy antibiotic molecules by modifying enzymes cell walls removing porins. A significant limitation traditional therapy lies its inability guarantee simultaneous delivery various cell, thereby fostering incremental either paths. Consequently, this approach prolongs treatment duration. Rather than using biologically unimportant coformer forming cocrystals, another molecule be selected for protecting or, complementary activities kill synergistically. development cocrystal not only improves tabletability plasticity but enables philosophically perfecting therapy. By adhering fundamental tenets therapy, synergistic effects effectively eradicate bacteria, even before they have chance develop resistance. has potential shorten periods, reduce costs, mitigate Herein, four hypotheses are presented create cocrystals capable simultaneously reaching cells, destroying them develop. ongoing surge novel provides opportunity fight against that constantly gaining existing treatments. endeavour holds combat wide array bacteria.

Язык: Английский

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Co-crystallization: a green approach for the solubility enhancement of poorly soluble drugs

CrystEngComm, Год журнала: 2023, Номер 26(3), С. 293 - 311

Опубликована: Ноя. 21, 2023

The co-crystallization of pharmaceutical drugs is gaining consideration because it an environmentally friendly and potentially effective technique to improve the solubility bioavailability poorly soluble drugs.

Язык: Английский

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Is Bismuth(III) able to inhibit the activity of urease? Puzzling results in the quest for soluble urease complexes for agrochemical and medicinal applications

Dalton Transactions, Год журнала: 2024, Номер 53(25), С. 10553 - 10562

Опубликована: Янв. 1, 2024

Novel Bi( iii ) complexes with improved solubility have been prepared and characterized for agrochemical medicinal applications; enzymatic tests conducted in vitro using C. ensiformis urease vivo cultures of H. pylori .

Язык: Английский

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What Has Carbamazepine Taught Crystal Engineers?

Crystal Growth & Design, Год журнала: 2024, Номер 24(17), С. 7342 - 7360

Опубликована: Июнь 21, 2024

The antiepilepsy drug carbamazepine is one of the most studied pharmaceuticals in world. rich story its solid forms, cocrystals, and formulation a microcosm topical world pharmaceutical materials. Understanding has required time, money, dedication from numerous researchers companies worldwide. This wealth knowledge provides opportunity to reflect on progress within crystal engineering field general. Perspective covers extensive form landscape applies these examples discuss answer fundamental questions discipline. encompasses screening methods, computational discovery, power influence understanding controlling crystals amorphous state, environmental legacy modern pharmaceuticals. broad but in-depth analysis vehicle into engineering, not only own right across spectrum organic materials science formulation. Discoveries demonstrate potential richness chemistry every drug.

Язык: Английский

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Drug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of Plasmodium spp. and prevents malaria pathogens from producing nucleic acid protein, thereby eliminating the parasites. Modifying structure through formation pharmaceutical cocrystal or salt presents an avenue which physicochemical properties can be optimized. In this work, we report design/synthesis solid-state characterization four new salts cocrystal-salt forms LMF; LMF-ADP salt, monoclinic space group P21/n; LMF-FUM cocrystal-salt, P21/c; LMF-TAR solvate LMF-SUC triclinic, P1̅ (ADP, dianion adipic acid; FUM, monoanion fumaric TAR, tartaric SUC, succinic acid). These obtained by solution as well mechanochemical cocrystallization methods. The multicomponent systems gain their stability hydrogen partial ionic bonding interactions (N-H···O, O-H···O, N+-H···O-, O-H+···O-) originating both dibutyl ammonium (N+-H) site alcohol hydroxyl (-OH) LMF toward carboxylate (-C(O-)═O) functional groups coformer anions. SCXRD indicates for LMF-ADP, LMF-TAR, complete transfer all carboxylic protons (H+) nitrogen, while LMF-FUM, one transferred (leaving hydrofumarate monoanion). Using salicylic acetylsalicylic acids coformers yielded coamorphous solids. Solid-state using powder X-ray diffraction (XRD) thermal techniques (DSC TGA) support confirm structures single-crystal XRD. present superior under standard conditions (40 ± 2 °C, 75 5% RH, 3 months) compared to amorphous samples other two salts. showed poor DSC/TGA, XRD patterns substantial change after 3-month test. Finally, calculated equilibrium solubilities indicate increase more than twofold LMF's solubility.

Язык: Английский

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High-Throughput Encapsulated Nanodroplet Screening for Accelerated Co-Crystal Discovery

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A high-throughput nanoscale co-crystallisation approach is presented, that combines automation and small scale to enable the exploration of conditions, resulting in 30 new binary, ternary quaternary co-crystals.

Язык: Английский

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Halogen Bonds Formed by Halogen’s p/π-Hole in Molecules Help Shape Crystalline Materials

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

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