Crystal Growth & Design,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
The
solid
form
screening
of
theophylline
(TP)
and
sulfuric
acid
led
to
a
collection
new
crystals
including
two
anhydrous
sulfate
salts
(TPH+HSO4–
I
TPH+HSO4–
II)
hydrated
(bis-theophyllinium
monohydrate
([TPH+]2SO42–·H2O)
theophyllinium
hydrogen
dihydrate
(TPH+HSO4–·2H2O)).
structures
were
determined
their
stability
was
investigated,
suggesting
multiple
modes
movement
for
the
ions
in
state.
Anhydrous
II
exhibits
unusually
large
anisotropic
linear
thermal
expansion,
associated
with
elongation
unique
sulfate−π
contact.
Additionally,
dehydration
TPH+HSO4–·2H2O
occurs
salient,
rocketlike
manner
that
may
be
caused
by
sudden
release
water
vapor
trapped
inside
particles.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(14)
Опубликована: Янв. 5, 2024
Abstract
Mechanochemical
reactions
offer
methodological
and
environmental
advantages
for
chemical
synthesis,
constantly
attracting
attention
within
the
scientific
community.
Besides
unmistakable
sustainability
advantages,
conditions
under
which
mechanochemical
occur,
namely
solventless
conditions,
sometimes
facilitate
isolation
of
otherwise
labile
or
inaccessible
products.
Despite
these
limited
knowledge
exists
regarding
mechanisms
types
intermediates
involved.
Nevertheless,
in
an
expanding
number
cases,
ex
situ
monitoring
techniques
have
allowed
observation,
characterization,
reaction
transformations.
In
this
Minireview,
we
present
a
series
examples
reactive
been
detected
spanning
organic,
organometallic,
inorganic,
materials
chemistry.
Many
were
stabilized
by
non‐covalent
interactions,
played
pivotal
role
guiding
We
believe
that
uncovering
understanding
such
instances,
growing
mechanochemistry
community
could
find
novel
opportunities
catalysis
discover
new
while
achieving
simplification
design.
BioMetals,
Год журнала:
2023,
Номер
37(3), С. 545 - 559
Опубликована: Дек. 19, 2023
Abstract
We
are
now
moving
into
the
antimicrobial
resistance
(AMR)
era
where
more
antibiotic
resistant
bacteria
majority,
a
problem
brought
on
by
both
misuse
and
over
use
of
antibiotics.
Unfortunately,
development
pipeline
dwindled
away
past
decades
as
they
not
very
profitable
compounds
for
companies
to
develop.
Regardless
researchers
decade
have
made
strides
explore
alternative
options
out
this
we
see
revisiting
historical
infection
control
agents
such
toxic
metals.
From
field
research
exploring
efficacy
metal
ions
complexes
antimicrobials.
Such
antimicrobials
delivered
in
variety
forms
from
salts,
alloys,
complexes,
organometallic
compounds,
based
nanomaterials
gives
us
broad
term
metalloantimicrobials.
many
effective
formulations
applied
various
applications
using
metals
that
against
drug
strains.
The
purpose
document
here
is
step
aside
begin
conversation
issues
microbes.
This
critical
opinion
mini-review
no
way
aims
be
comprehensive.
goal
understand
benefits
metalloantimicrobials,
but
also
consider
strongly
disadvantages
metals,
what
potential
consequences
overuse.
need
conscious
issues,
entire
system
affect
through
OneHealth
vision.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(38)
Опубликована: Июль 2, 2024
Lanthanide
(Ln)
based
mononuclear
single-molecule
magnets
(SMMs)
provide
probably
the
finest
ligand
regulation
model
for
magnetic
property.
Recently,
development
of
such
SMMs
has
witnessed
a
fast
transition
from
coordination
to
organometallic
complexes
because
latter
provides
fertile,
yet
not
fully
excavated
soil
SMMs.
Especially
those
with
heterocyclic
ligands
have
shown
potential
reach
higher
blocking
temperature.
In
this
minireview,
we
give
an
overview
design
principle
and
highlight
"shining
stars"
organolanthanide
on
ring
sizes
ligands,
analysing
how
electronic
structures
stiffness
subsequently
formed
molecules
affect
dynamic
magnetism
Finally,
envisaged
future
Ln-SMMs.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 13, 2024
The
inappropriate
and
inconsistent
use
of
antibiotics
in
combating
multidrug-resistant
bacteria
exacerbates
their
drug
resistance
through
a
few
distinct
pathways.
Firstly,
these
can
accumulate
multiple
genes,
each
conferring
to
specific
drug,
within
single
cell.
This
accumulation
usually
takes
place
on
plasmids
(R).
Secondly,
multidrug
arise
from
the
heightened
expression
genes
encoding
efflux
pumps,
which
expel
broad
spectrum
drugs
bacterial
cells.
Additionally,
also
eliminate
or
destroy
antibiotic
molecules
by
modifying
enzymes
cell
walls
removing
porins.
A
significant
limitation
traditional
therapy
lies
its
inability
guarantee
simultaneous
delivery
various
cell,
thereby
fostering
incremental
either
paths.
Consequently,
this
approach
prolongs
treatment
duration.
Rather
than
using
biologically
unimportant
coformer
forming
cocrystals,
another
molecule
be
selected
for
protecting
or,
complementary
activities
kill
synergistically.
development
cocrystal
not
only
improves
tabletability
plasticity
but
enables
philosophically
perfecting
therapy.
By
adhering
fundamental
tenets
therapy,
synergistic
effects
effectively
eradicate
bacteria,
even
before
they
have
chance
develop
resistance.
has
potential
shorten
periods,
reduce
costs,
mitigate
Herein,
four
hypotheses
are
presented
create
cocrystals
capable
simultaneously
reaching
cells,
destroying
them
develop.
ongoing
surge
novel
provides
opportunity
fight
against
that
constantly
gaining
existing
treatments.
endeavour
holds
combat
wide
array
bacteria.
CrystEngComm,
Год журнала:
2023,
Номер
26(3), С. 293 - 311
Опубликована: Ноя. 21, 2023
The
co-crystallization
of
pharmaceutical
drugs
is
gaining
consideration
because
it
an
environmentally
friendly
and
potentially
effective
technique
to
improve
the
solubility
bioavailability
poorly
soluble
drugs.
Dalton Transactions,
Год журнала:
2024,
Номер
53(25), С. 10553 - 10562
Опубликована: Янв. 1, 2024
Novel
Bi(
iii
)
complexes
with
improved
solubility
have
been
prepared
and
characterized
for
agrochemical
medicinal
applications;
enzymatic
tests
conducted
in
vitro
using
C.
ensiformis
urease
vivo
cultures
of
H.
pylori
.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(17), С. 7342 - 7360
Опубликована: Июнь 21, 2024
The
antiepilepsy
drug
carbamazepine
is
one
of
the
most
studied
pharmaceuticals
in
world.
rich
story
its
solid
forms,
cocrystals,
and
formulation
a
microcosm
topical
world
pharmaceutical
materials.
Understanding
has
required
time,
money,
dedication
from
numerous
researchers
companies
worldwide.
This
wealth
knowledge
provides
opportunity
to
reflect
on
progress
within
crystal
engineering
field
general.
Perspective
covers
extensive
form
landscape
applies
these
examples
discuss
answer
fundamental
questions
discipline.
encompasses
screening
methods,
computational
discovery,
power
influence
understanding
controlling
crystals
amorphous
state,
environmental
legacy
modern
pharmaceuticals.
broad
but
in-depth
analysis
vehicle
into
engineering,
not
only
own
right
across
spectrum
organic
materials
science
formulation.
Discoveries
demonstrate
potential
richness
chemistry
every
drug.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Lumefantrine
(LMF)
is
a
low-solubility
antimalarial
drug
that
cures
acute,
uncomplicated
malaria.
It
exerts
its
pharmacological
effects
against
erythrocytic
stages
of
Plasmodium
spp.
and
prevents
malaria
pathogens
from
producing
nucleic
acid
protein,
thereby
eliminating
the
parasites.
Modifying
structure
through
formation
pharmaceutical
cocrystal
or
salt
presents
an
avenue
which
physicochemical
properties
can
be
optimized.
In
this
work,
we
report
design/synthesis
solid-state
characterization
four
new
salts
cocrystal-salt
forms
LMF;
LMF-ADP
salt,
monoclinic
space
group
P21/n;
LMF-FUM
cocrystal-salt,
P21/c;
LMF-TAR
solvate
LMF-SUC
triclinic,
P1̅
(ADP,
dianion
adipic
acid;
FUM,
monoanion
fumaric
TAR,
tartaric
SUC,
succinic
acid).
These
obtained
by
solution
as
well
mechanochemical
cocrystallization
methods.
The
multicomponent
systems
gain
their
stability
hydrogen
partial
ionic
bonding
interactions
(N-H···O,
O-H···O,
N+-H···O-,
O-H+···O-)
originating
both
dibutyl
ammonium
(N+-H)
site
alcohol
hydroxyl
(-OH)
LMF
toward
carboxylate
(-C(O-)═O)
functional
groups
coformer
anions.
SCXRD
indicates
for
LMF-ADP,
LMF-TAR,
complete
transfer
all
carboxylic
protons
(H+)
nitrogen,
while
LMF-FUM,
one
transferred
(leaving
hydrofumarate
monoanion).
Using
salicylic
acetylsalicylic
acids
coformers
yielded
coamorphous
solids.
Solid-state
using
powder
X-ray
diffraction
(XRD)
thermal
techniques
(DSC
TGA)
support
confirm
structures
single-crystal
XRD.
present
superior
under
standard
conditions
(40
±
2
°C,
75
5%
RH,
3
months)
compared
to
amorphous
samples
other
two
salts.
showed
poor
DSC/TGA,
XRD
patterns
substantial
change
after
3-month
test.
Finally,
calculated
equilibrium
solubilities
indicate
increase
more
than
twofold
LMF's
solubility.
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
high-throughput
nanoscale
co-crystallisation
approach
is
presented,
that
combines
automation
and
small
scale
to
enable
the
exploration
of
conditions,
resulting
in
30
new
binary,
ternary
quaternary
co-crystals.