I2–DMSO-mediated formal [3 + 1 + 2] synthesis of pyrimido[1,2-b]indazole using 1,4-dithiane-2,5-diol as a surrogate of ethylene

Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155453 - 155453

Опубликована: Янв. 9, 2025

Язык: Английский

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I₂/DMSO Mediated [5+1] Oxidative Annulation of Aryl Methyl Ketones with 2‐(2H‐Indazol‐2‐yl)anilines for the Synthesis of Indazoloquinoxalines

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Abstract A metal‐free, iodine‐mediated protocol has been developed to synthesize indazoloquinoxaline derivatives from readily accessible substrates such as 2‐(2 H ‐indazol‐2‐yl)anilines and aryl methyl ketones. This operationally simple, one‐pot reaction proceeds through iodine/DMSO‐mediated C(sp 3 )‐H oxidation of ketones, followed by imine formation annulation furnish the desired products. wide range including drug‐derived substrates, were compatible in present reaction. Further, is scalable, demonstrating its applicability on a larger scale.

Язык: Английский

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Divergent Synthesis of Pyrrolidone Fused Pyrimido[1,2-b]indazole through Selective Trapping of Enone Intermediate by 1H-indazol-3-amine

Chemical Communications, Год журнала: 2024, Номер 60(72), С. 9781 - 9784

Опубликована: Янв. 1, 2024

An oxidant-controlled divergent synthesis of a pyrrolidone fused pyrimido[1,2- b ]indazole skeleton was developed through selective cyclization an in situ generated enone intermediate and 1 H -indazol-3-amine.

Язык: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 355 - 393

Опубликована: Янв. 1, 2024

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