Abstract
A
mechanochemical,
highly
regioselective
rhodium(III)‐catalyzed
C─H
methylation
of
8‐methylquinolines
is
reported.
The
method
reported
in
this
study,
often
solvent‐free
or
uses
minimal
solvent
(liquid
assisted
grinding),
operates
without
external
heating
under
mild
reaction
conditions,
demonstrating
tolerance
for
various
functional
groups.
Moreover,
the
time
significantly
reduced
compared
to
solvent‐based
variant.
Notably,
can
be
carried
out
using
a
pestle
and
mortar
instead
ball
milling
as
well,
highlighting
operational
simplicity
approach
achieving
challenging
C(sp
3
)‐H
activation
more
sustainable
conditions.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(14)
Опубликована: Янв. 5, 2024
Abstract
Mechanochemical
reactions
offer
methodological
and
environmental
advantages
for
chemical
synthesis,
constantly
attracting
attention
within
the
scientific
community.
Besides
unmistakable
sustainability
advantages,
conditions
under
which
mechanochemical
occur,
namely
solventless
conditions,
sometimes
facilitate
isolation
of
otherwise
labile
or
inaccessible
products.
Despite
these
limited
knowledge
exists
regarding
mechanisms
types
intermediates
involved.
Nevertheless,
in
an
expanding
number
cases,
ex
situ
monitoring
techniques
have
allowed
observation,
characterization,
reaction
transformations.
In
this
Minireview,
we
present
a
series
examples
reactive
been
detected
spanning
organic,
organometallic,
inorganic,
materials
chemistry.
Many
were
stabilized
by
non‐covalent
interactions,
played
pivotal
role
guiding
We
believe
that
uncovering
understanding
such
instances,
growing
mechanochemistry
community
could
find
novel
opportunities
catalysis
discover
new
while
achieving
simplification
design.
Abstract
As
of
December
2023,
the
use
common
solvent
N
,
‐dimethyl
formamide
(DMF)
will
be
restricted
in
European
Union
because
its
reproductive
health
hazard.
Industrial
facilities
must
comply
with
stricter
exposure
limits,
and
researchers
are
recommended
to
find
alternative
solvents.
Here
we
explain
restrictions
on
DMF,
which
disciplines
affected,
how
substitute
DMF
keep
research
development
commercially
relevant.
Abstract
Piezoelectric
materials
offer
great
promise
due
to
their
ability
generate
electric
fields
under
mechanical
stress,
producing
surface
charges
that
drive
otherwise
kinetically
sluggish
redox
reactions.
The
strained
surfaces
of
these
provide
a
unique
advantage
in
controlling
product
selectivity
and
enabling
reaction
pathways
are
unattainable
with
conventional
methods.
This
perspective
highlights
advancements,
challenges,
the
future
potential
piezoelectric
synthetic
organic
chemistry,
focus
on
designing
optimized
for
piezocatalyzed
synthesis.
Piezocatalysis
is
industrially
relevant
because
its
operational
simplicity,
mild,
gram
scale
synthesis
reusable
catalysts,
minimal
solvent
use,
air
tolerant
conditions.
It
involves
cycles
facilitate
one
electron
events
without
requiring
light
exposure
or
electrical
bias.
Despite
significant
progress,
many
fundamental
aspects
yet
be
fully
understood.
One
example
correlation
between
piezoelectricity
catalytic
activity,
which
not
always
linear,
as
demonstrated
by
comparison
tetragonal
cubic
BaTiO₃.
While
BaTiO₃
piezoelectric,
it
shows
excellent
activity
certain
reactions
such
arylation,
dicarbonylation,
cyclization
mechanochemical
conditions
comparable
Considering
all
aspects,
this
aims
stimulate
discussion
advance
promising
field
right
direction.
RSC Mechanochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Subtle
differences
in
how
pyridine
is
introduced
can
direct
mechanochemical
reactivity
by
enabling
bond
activation
and
favoring
one
reaction
pathway
over
another.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(14)
Опубликована: Янв. 5, 2024
Abstract
Mechanochemical
reactions
offer
methodological
and
environmental
advantages
for
chemical
synthesis,
constantly
attracting
attention
within
the
scientific
community.
Besides
unmistakable
sustainability
advantages,
conditions
under
which
mechanochemical
occur,
namely
solventless
conditions,
sometimes
facilitate
isolation
of
otherwise
labile
or
inaccessible
products.
Despite
these
limited
knowledge
exists
regarding
mechanisms
types
intermediates
involved.
Nevertheless,
in
an
expanding
number
cases,
ex
situ
monitoring
techniques
have
allowed
observation,
characterization,
reaction
transformations.
In
this
Minireview,
we
present
a
series
examples
reactive
been
detected
spanning
organic,
organometallic,
inorganic,
materials
chemistry.
Many
were
stabilized
by
non‐covalent
interactions,
played
pivotal
role
guiding
We
believe
that
uncovering
understanding
such
instances,
growing
mechanochemistry
community
could
find
novel
opportunities
catalysis
discover
new
while
achieving
simplification
design.
