Stereoselective (3 + 3)-Cycloannulation of Carbonyl Ylides and (Z)-3-Benzylidene-3H-indoles Enabled by Cooperative Rh/Chiral Phosphoric Acid Catalysis
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
A
diastereo-
and
enantioselective
(3
+
3)-cycloannulation
of
in
situ
generated
carbonyl
ylides
(Z)-3-benzylidene-3H-indoles
enabled
by
cooperative
Rh/chiral
phosphoric
acid
catalysis
is
reported.
This
study
the
first
to
describe
an
synthesis
cyclohepta[b]indole
with
oxa-bridged
motif.
The
scope
reaction
broad,
products
were
obtained
moderate
good
yields
excellent
diastereoselectivities
high
enantioselectivities.
Язык: Английский
Construction of central and axial chirality via Pd(II)/Bim-catalyzed asymmetric dearomative Michael reaction of polycyclic tropones
Chemical Communications,
Год журнала:
2024,
Номер
60(67), С. 8908 - 8911
Опубликована: Янв. 1, 2024
A
highly
enantioselective
Pd/Bim-catalyzed
dearomative
Michael
reaction
applying
polycyclic
tropones
as
non-benzenoid
aromatic
acceptors
and
arylboronic
acids
aryl
pronucleophiles
has
been
developed.
The
bridged
biaryls
bearing
central
axial
chirality,
including
pentacyclic
cyclohepta[
Язык: Английский
Site Specific C3‐Alkenylation of Indoles Mediated by in situ C‐H Iodination
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Abstract
The
C3‐alkenylation
of
indoles
have
been
developed
by
means
a
novel
in
situ
iodination
tactic
which
is
capable
mediating
the
Heck
coupling
with
alkenes.
method
features
specific
site‐selectivity
oriented
C−I
bond,
high‐step
efficiency
without
pre‐functionalization
for
C‐halogen
bond
construction,
as
well
highly
general
tolerance
to
different
terminal
alkenes,
including
unactivated
acrylates,
acrylic
acid,
vinyl
sulfone
functionalized
natural
products.
Язык: Английский