Taming Inert B–H Bond with Low Energy Light: A Near-Infrared Light-Induced Approach to Facile Carborane Cluster-Amino Acid Coupling
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
selective
functionalization
of
inert
B–H
bonds
in
carborane
clusters
has
been
a
formidable
challenge.
Recent
advances
have
witnessed
such
reactions
through
photoredox
methods
utilizing
ultraviolet
or
visible
light
irradiation.
However,
high-energy
sources
often
suffer
from
poor
energy
efficiency,
limited
substrate
scope,
undesired
side
reactions,
and
low
scalability.
Here,
we
present
the
first
successful
bond
under
low-energy
near-infrared
(NIR)
using
carborane-based
electron
donor–acceptor
complex.
Both
photophysical
investigations
theoretical
modeling
reveal
facile
single-electron
transfer
cage
to
electron-deficient
photocatalyst,
generating
radical
NIR
follow-up
pathway
enables
direct
coupling
carboranes
with
amino
acids
oligopeptides,
yielding
diverse
array
carborane-functionalized
oligopeptides.
Beyond
expanding
known
chemical
space
boron
cluster
derivatives,
further
demonstrate
that
imaging
targeting
capabilities
could
serve
as
promising
multifunctional
carriers
for
neutron
capture
therapy.
Thus,
via
not
only
provides
straightforward
practical
strategy
synthetic
chemistry
but
also
lays
foundation
development
next-generation
boron-containing
biomolecules
advanced
functional
materials.
Язык: Английский
A comparative study on nido- and closo-carborane supported zinc-salen catalysts for the ROCOP of epoxides and anhydrides
Dalton Transactions,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Nido
-C
2
B
9
carborane
anion
supported
Zn–salen
complexes
are
superior
to
closo
-carborane
ones
in
ROCOP
of
epoxides
and
anhydrides.
Язык: Английский
Palladium-Catalyzed Regioselective B(3,4,5,6)–H Tetra-Arylation of o-Carboranes
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
A
transition-metal-catalyzed
iterative
multiple
cage
B-H
activation
reaction
for
constructing
multifunctionalization
of
o-carboranes
in
one
pot
is
challenging.
Herein,
palladium-catalyzed
regioselective
tetra-arylation
a
wide
range
C(1)-N-aryl-o-carboranyl
amides
with
aryl
iodides
has
been
developed.
variety
B(3,4,5,6)-tetra-arylated
were
synthesized
good-to-excellent
yields.
Moreover,
the
mono-,
di-,
and
triarylated
intermediate
products
isolated,
exact
structures
determined
by
NMR,
high-resolution
mass
spectrometry,
X-ray
analysis,
which
provide
rationale
that
order
introduction
groups
into
o-carborane
B(4)
>
B(5)
B(3)/B(6).
This
protocol
represents
powerful
synthetic
method
polyfunctionalization
derivatives
under
very
mild
simple
conditions,
offers
valuable
reference
design
synthesis
molecular
propellers
based
on
carboranes.
Язык: Английский