Expanding the Bowknot-like Morphological Versatility in Supramolecular Assemblies of Diphenylalanine DOI
Shiwei Bai, Panpan Sun, Nan Sun

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 136067 - 136067

Опубликована: Дек. 1, 2024

Язык: Английский

Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities DOI
Saisai Wang, Jian‐Yong Wu, Yuan Tian

и другие.

Science China Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Язык: Английский

Процитировано

5
Engineering Multifunctional Peptide-Decorated Nanofibers for Targeted Delivery of Temozolomide across the Blood–Brain Barrier DOI Creative Commons
Rosa Bellavita, Teresa Barra, Simone Braccia

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

A nanoplatform based on self-assembling peptides was developed with the ability to effectively transport and deliver a wide range of moieties across blood–brain barrier (BBB) for treatment glioblastoma. Its surface functionalized have targeted release TMZ thanks targeting peptide that binds EGFRvIII, which is overexpressed tumor cells, gH625, acts as an enhancer penetration. Furthermore, on-demand achieved through matrix metalloproteinase-9 (MMP-9) cleavage. Nanofibers were characterized their stability, critical aggregation concentration, morphology. Next, effect both 2D 3D glioblastoma/astrocytoma (U-87) glioma (U-118) cell lines evaluated. The Annexin V/Propidium iodide showed increase in necrotic apoptotic morphological analysis allowed discover U-118 U-87 spheroids are smaller surface, perimeter, Feret's diameter when treated NF-TMZ. nanofiber demonstrated permeate BBB vitro spheroidal biodynamic model. Finally, there no cytotoxic effects nanofibers without drug spheroids, while significant decrease viability observed NF-TMZ used. Overall, these results open new opportunities evaluation efficacy safety this vivo studies.

Язык: Английский

Процитировано

0
In situ peptide assembly for cell membrane rewiring in tumor therapy DOI
Yu Ma, Qiaochu Jiang, Xiaoyang Liu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113637 - 113637

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Evaluation of the electrochemical response of aromatic peptides for biodetection of dopamine DOI
Adrián Fontana‐Escartín, Elisabetta Rosa, Carlo Diaferia

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 441 - 454

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

0
Self-assembly of Natural Products of TCM and Bioactive Materials DOI Creative Commons

Dongxue Liu,

Miao Zhang,

Xinghua Sun

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер unknown, С. 100559 - 100559

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0
Expanding the Bowknot-like Morphological Versatility in Supramolecular Assemblies of Diphenylalanine DOI
Shiwei Bai, Panpan Sun, Nan Sun

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер unknown, С. 136067 - 136067

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0