Опубликована: Авг. 23, 2024

Cyano groups represent an important class of functional motifs in medicinal chemistry given their synthetic versatility and capacity to engage essential interactions with biological targets. However, the synthesis sterically hindered alkyl nitriles using non-toxic reagents remains challenging. Traditional methods often rely on toxic cyanide sources suffer from limited substrate scope. Herein, we report a photoredox catalyzed, metal-free deoxycyanation alcohols that allows rapid access wide array 1º, 2º, 3º cyanides reagents.

Язык: Английский