Alkoxy Radical‐Triggered 1,1,2‐Trifunctionalization of Unactivated Alkenes towards N,O‐Spiroaminals

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Comprehensive Summary N,O‐Spiroaminals have potential biological activities and abilities to modulate the physicochemical pharmacokinetic properties of drug molecules. However, effective catalytic methods for efficient construction N,O‐spiroaminals are still limited date. Herein, we report a novel 1,1,2‐trifunctionalization unactivated alkenes rapidly efficiently obtain diverse array architecturally intriguing N,O‐spiroaminals. This methodology exhibits broad substrate scope, good functional group compatibility, synthetic utility by scale‐up reaction, product derivatizations late‐stage functionalization complex biorelevant molecule. Notably, this transformation selectively allows formation three new chemical bonds (C–O, C–C, C–N) one spiro quaternary carbon center across C‐C double bonds.

Язык: Английский

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Enantioselective intramolecular tandem cyclization of o-alkynylbenzamides: generation of enantioenriched CF₃-containing spiro-isoindolinone-indoles

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(9), С. 2591 - 2599

Опубликована: Янв. 1, 2024

Enantioselective intramolecular tandem cyclization of dielectrophile–dinucleophile assembled o -alkynylbenzamides provided a variety spiro-isoindolinone-indoles in low to moderate yields with good enantioselectivities.

Язык: Английский

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Enantioselective synthesis of 2-amino-4H-chromene derivatives with antifungal activities on phytopathogenic fungi

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(13), С. 3692 - 3699

Опубликована: Янв. 1, 2024

An Ir-catalyzed enantioselective cascade allylation/cyclization reaction of 2-(1-hydroxyallyl)phenols was developed, affording antifungal 2-amino-4 H -chromene derivatives with good to excellent enantioselectivities.

Язык: Английский

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Photoredox-catalyzed C(sp²)–H trifluoromethylation of 3-methylene-isoindolin-1-ones under metal-free conditions

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(34), С. 6928 - 6932

Опубликована: Янв. 1, 2024

A facile synthetic method for direct C(sp 2 )–H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented.

Язык: Английский

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