Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide DOI Creative Commons

Yujuan Wu,

Chen Ma, Muhammad Bılal

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 6016 - 6016

Опубликована: Дек. 20, 2024

Nitriles are valuable compounds because they have widespread applications in organic chemistry. This report details the nickel-catalyzed reductive cyanation of aryl halides and epoxides with cyanogen bromide for synthesis nitriles. robust protocol underscores practicality using a commercially available cost-effective reagent. A variety featuring diverse functional groups, such as -TMS, -Bpin, -OH, -NH2, -CN, -CHO, were successfully converted into nitriles moderate-to-good yields. Moreover, syntheses at gram-scale application late-stage natural products drugs reinforces its potentiality.

Язык: Английский

Advances in the Synthesis of α-Trifluoromethyl Ketones and Their Application via Defluorinative Reactions DOI
Sufang Cao, Yunyun Liu, Jie‐Ping Wan

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(1), С. 86 - 86

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Nickel-catalysed highly regioselective synthesis of β-acyl naphthalenes under reductive conditions DOI

Yujuan Wu,

Chen Ma,

Jia-Fan Qiao

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(44), С. 5723 - 5726

Опубликована: Янв. 1, 2024

A nickel-catalysed reductive ring-opening reaction of 7-oxabenzonorbornadienes with acyl chlorides as the electrophilic coupling partner was developed, generating β-acyl naphthalene unique product without any α iso.

Язык: Английский

Процитировано

2
Transition-Metal-Free Hydrodefluoroamination of Trifluoromethyl Enones for the Synthesis of α-Fluoroenamides DOI

Ya‐Fei Hu,

M Kellis,

Ming-Yao Tang

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10299 - 10310

Опубликована: Июль 2, 2024

A three-component strategy was developed to enable hydrodefluoroamination of β-trifluoromethyl enones by selectively activating two C(sp3)-F bonds in the trifluoromethyl group. The method involved a sequence carbonyl reduction, hydrodefluorination, and defluoroamination under transition-metal-free conditions. Synthetically useful (E)-stereospecific α-fluoroenamides were obtained good yields with diverse functional group tolerance, which could be easily transformed into valuable organofluorides heterocycles. auxiliary exerts both electronic steric impacts on CF3-alkenes, allowing for controllable selective defluorination.

Язык: Английский

Процитировано

0
Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide DOI Creative Commons

Yujuan Wu,

Chen Ma, Muhammad Bılal

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 6016 - 6016

Опубликована: Дек. 20, 2024

Nitriles are valuable compounds because they have widespread applications in organic chemistry. This report details the nickel-catalyzed reductive cyanation of aryl halides and epoxides with cyanogen bromide for synthesis nitriles. robust protocol underscores practicality using a commercially available cost-effective reagent. A variety featuring diverse functional groups, such as -TMS, -Bpin, -OH, -NH2, -CN, -CHO, were successfully converted into nitriles moderate-to-good yields. Moreover, syntheses at gram-scale application late-stage natural products drugs reinforces its potentiality.

Язык: Английский

Процитировано

0