Patient-Specific Nanoparticle Targeting in Human Leukemia Blood
ACS Nano,
Год журнала:
2024,
Номер
18(42), С. 29021 - 29035
Опубликована: Окт. 9, 2024
Antibody-directed
targeting
of
chemotherapeutic
nanoparticles
to
primary
human
cancers
holds
promise
for
improving
efficacy
and
reducing
off-target
toxicity.
However,
clinical
responses
targeted
nanomedicines
are
highly
variable.
Herein,
we
prepared
examined
a
matrix
9
particles
(organic
inorganic
three
surface
chemistries
with
without
antibody
functionalization)
developed
an
Язык: Английский
The Role of Human Intestinal Mucus in the Prevention of Microplastic Uptake and Cell Damage
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
increase
in
plastic
waste
and
its
release
into
the
environment
has
led
to
health
concerns
over
microplastics
(MPs)
environment.
The
intestinal
mucosal
layer
is
a
key
defense
mechanism
against
ingested
MPs,
preventing
migration
of
particles
other
parts
body.
MP
through
mucus
challenging
study
due
difficulties
obtaining
intact
layers
for
testing
numerous
formulations,
shapes,
sizes
microplastics.
Previous
studies
have
primarily
used
from
animals,
hydrogel
models,
samples
body
as
substitutes.
This
examines
how
different
compositions,
(40-500
nm),
surface
functionalizations
alter
human
mucus;
protects
cells
uptake,
toxicity,
inflammation;
prevents
environmental
toxins
via
particles.
presence
also
provides
critical
protection
cytotoxicity,
reactive
oxygen
species
production,
uptake
all
tested,
although
certain
functionalizations,
such
streptavidin,
are
particularly
harmful
with
high
toxicity
inflammation.
Understanding
properties
that
assist
impede
diffusion
MPs
relevant
overall
bioaccumulation
effects
well
drug
delivery
purposes.
Язык: Английский
Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(6), С. 3568 - 3598
Опубликована: Май 30, 2024
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
with
the
worst
prognosis
and
highest
recurrence
rates.
The
treatment
choices
are
limited
due
to
scarcity
of
endocrine
HER2
targets,
except
for
chemotherapy.
However,
side
effects
chemotherapy
restrict
its
long-term
usage.
Immunotherapy
shows
potential
as
a
promising
therapeutic
strategy,
such
inducing
immunogenic
cell
death,
immune
checkpoint
therapy,
adjuvant
therapy.
Nanotechnology
offers
unique
advantages
in
field
immunotherapy,
improved
delivery
targeted
release
immunotherapeutic
agents
enhanced
bioavailability
immunomodulators.
As
well
combination
therapy
synergistically
by
nanocarriers.
Nanoparticles-based
combined
application
multiple
immunotherapies
designed
take
tactics
enhancing
immunogenicity
reversing
immunosuppression.
Moreover,
increasing
abundance
biomedical
materials
holds
more
promise
development
this
field.
This
review
summarizes
advances
nanoparticle-mediated
immunotherapy
terms
both
strategies
biomaterials
presents
challenges
hopes
future.
Язык: Английский
Targeting of Low‐Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal‐Enhanced Immunotherapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
The
assembly
of
low‐immunogenic
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
for
targeted
delivery
therapeutics
(i.e.,
mitoxantrone
and
imidazoquinoline)
improved
photothermal‐immunotherapy
is
reported.
PEG
NPs
incorporating
targeting
molecules
hyaluronic
acid
are
engineered
via
the
templating
metal–organic
frameworks,
which
can
circumvent
accelerated
blood
clearance
exhibit
prolonged
circulation
time
as
well
accumulation
at
tumor
sites.
under
laser
radiation
induces
immunogenic
cell
death
cells,
combined
with
toll‐like
receptor
7/8
agonists
imidazoquinoline
to
trigger
immune
responses
cytotoxic
T
lymphocytes
eradication
cells.
Furthermore,
treatment
induce
tumor‐specific
that
inhibit
metastatic
lung
growth.
This
reported
provide
a
rational
design
cancer
immunotherapy.
Язык: Английский
A nanoprodrug derived from branched poly (ethylene glycol) recognizes prostate-specific membrane antigen to precisely suppress prostate cancer progression
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 136831 - 136831
Опубликована: Окт. 23, 2024
Язык: Английский
Fluorescent Polymer Nanocomposites as Novel Drug-Loading and Targeted Delivery Nanocarriers for Glioma Therapy by Modulating ERBB4
Journal of Fluorescence,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
Язык: Английский
Ex vivo human leukemia blood model illustrates limitations of cancer-targeting PEGylated nanoparticles
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 31, 2024
Abstract
Antibody-directed
targeting
of
chemotherapeutic
nanomaterials
to
primary
human
cancers
could
improve
efficacy
and
reduce
off-target
toxicities.
We
developed
an
ex
vivo
model
study
the
Chronic
Lymphocytic
Leukemia
(CLL)
in
whole
blood
samples
from
15
subjects
with
CLL.
Anti-CD20
targeted
polyethylene
glycol
(PEG)-based
nanoparticles
had
generally
efficient
CLL
cells
low
phagocytosis
by
neutrophils
monocytes.
There
was
however
substantial
patient-patient
variability
(up
164-fold
difference
targeting),
driven
part
variance
pre-existing
anti-PEG
antibodies
which
reduced
effects.
This
suggests
patients
lower
PEG
antibody
levels
may
benefit
more
therapies.
further
exemplified
antibody-functionalized
doxorubicin-containing
PEGylated
liposomes,
relatively
poor
high
uptake
(significantly
correlated
IgG
blood)
killing
almost
all
monocytes
within
24
hours.
Personalized
low-fouling
non-PEGylated
particle
systems
are
needed
realize
potential
chemotherapies.
Overall,
our
tumor
antibody-directed
delineates
limitations
opportunities
tumor-targeting
nanomedicines.
Язык: Английский