Ex vivo human leukemia blood model illustrates limitations of cancer-targeting PEGylated nanoparticles DOI Open Access
Yi Ju, Shiyao Li,

Abigail Er Qi Tan

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 31, 2024

Abstract Antibody-directed targeting of chemotherapeutic nanomaterials to primary human cancers could improve efficacy and reduce off-target toxicities. We developed an ex vivo model study the Chronic Lymphocytic Leukemia (CLL) in whole blood samples from 15 subjects with CLL. Anti-CD20 targeted polyethylene glycol (PEG)-based nanoparticles had generally efficient CLL cells low phagocytosis by neutrophils monocytes. There was however substantial patient-patient variability (up 164-fold difference targeting), driven part variance pre-existing anti-PEG antibodies which reduced effects. This suggests patients lower PEG antibody levels may benefit more therapies. further exemplified antibody-functionalized doxorubicin-containing PEGylated liposomes, relatively poor high uptake (significantly correlated IgG blood) killing almost all monocytes within 24 hours. Personalized low-fouling non-PEGylated particle systems are needed realize potential chemotherapies. Overall, our tumor antibody-directed delineates limitations opportunities tumor-targeting nanomedicines.

Язык: Английский

Patient-Specific Nanoparticle Targeting in Human Leukemia Blood DOI Creative Commons
Yi Ju, Shiyao Li,

Abigail Er Qi Tan

и другие.

ACS Nano, Год журнала: 2024, Номер 18(42), С. 29021 - 29035

Опубликована: Окт. 9, 2024

Antibody-directed targeting of chemotherapeutic nanoparticles to primary human cancers holds promise for improving efficacy and reducing off-target toxicity. However, clinical responses targeted nanomedicines are highly variable. Herein, we prepared examined a matrix 9 particles (organic inorganic three surface chemistries with without antibody functionalization) developed an

Язык: Английский

Процитировано

10

The Role of Human Intestinal Mucus in the Prevention of Microplastic Uptake and Cell Damage DOI Creative Commons
Ellen van Wijngaarden, Sandra L. Arias, Matthew W. Rhee

и другие.

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

An increase in plastic waste and its release into the environment has led to health concerns over microplastics (MPs) environment. The intestinal mucosal layer is a key defense mechanism against ingested MPs, preventing migration of particles other parts body. MP through mucus challenging study due difficulties obtaining intact layers for testing numerous formulations, shapes, sizes microplastics. Previous studies have primarily used from animals, hydrogel models, samples body as substitutes. This examines how different compositions, (40-500 nm), surface functionalizations alter human mucus; protects cells uptake, toxicity, inflammation; prevents environmental toxins via particles. presence also provides critical protection cytotoxicity, reactive oxygen species production, uptake all tested, although certain functionalizations, such streptavidin, are particularly harmful with high toxicity inflammation. Understanding properties that assist impede diffusion MPs relevant overall bioaccumulation effects well drug delivery purposes.

Язык: Английский

Процитировано

2

Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer DOI Creative Commons
Ruoyi Wang, Xu Huang, Xiaoxi Chen

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(6), С. 3568 - 3598

Опубликована: Май 30, 2024

Triple-negative breast cancer (TNBC) is an aggressive subtype with the worst prognosis and highest recurrence rates. The treatment choices are limited due to scarcity of endocrine HER2 targets, except for chemotherapy. However, side effects chemotherapy restrict its long-term usage. Immunotherapy shows potential as a promising therapeutic strategy, such inducing immunogenic cell death, immune checkpoint therapy, adjuvant therapy. Nanotechnology offers unique advantages in field immunotherapy, improved delivery targeted release immunotherapeutic agents enhanced bioavailability immunomodulators. As well combination therapy synergistically by nanocarriers. Nanoparticles-based combined application multiple immunotherapies designed take tactics enhancing immunogenicity reversing immunosuppression. Moreover, increasing abundance biomedical materials holds more promise development this field. This review summarizes advances nanoparticle-mediated immunotherapy terms both strategies biomaterials presents challenges hopes future.

Язык: Английский

Процитировано

3

Targeting of Low‐Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal‐Enhanced Immunotherapy DOI
Mengqi Li, Zhiliang Gao, Ning Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 15, 2024

Abstract The assembly of low‐immunogenic poly(ethylene glycol) nanoparticles (PEG NPs) for targeted delivery therapeutics (i.e., mitoxantrone and imidazoquinoline) improved photothermal‐immunotherapy is reported. PEG NPs incorporating targeting molecules hyaluronic acid are engineered via the templating metal–organic frameworks, which can circumvent accelerated blood clearance exhibit prolonged circulation time as well accumulation at tumor sites. under laser radiation induces immunogenic cell death cells, combined with toll‐like receptor 7/8 agonists imidazoquinoline to trigger immune responses cytotoxic T lymphocytes eradication cells. Furthermore, treatment induce tumor‐specific that inhibit metastatic lung growth. This reported provide a rational design cancer immunotherapy.

Язык: Английский

Процитировано

2

A nanoprodrug derived from branched poly (ethylene glycol) recognizes prostate-specific membrane antigen to precisely suppress prostate cancer progression DOI
Shiwei Guo, Yu Cao, Bowen Cheng

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136831 - 136831

Опубликована: Окт. 23, 2024

Язык: Английский

Процитировано

1

Fluorescent Polymer Nanocomposites as Novel Drug-Loading and Targeted Delivery Nanocarriers for Glioma Therapy by Modulating ERBB4 DOI

Jian Li,

Huiqing Lv, Fei Wu

и другие.

Journal of Fluorescence, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

0

Ex vivo human leukemia blood model illustrates limitations of cancer-targeting PEGylated nanoparticles DOI Open Access
Yi Ju, Shiyao Li,

Abigail Er Qi Tan

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 31, 2024

Abstract Antibody-directed targeting of chemotherapeutic nanomaterials to primary human cancers could improve efficacy and reduce off-target toxicities. We developed an ex vivo model study the Chronic Lymphocytic Leukemia (CLL) in whole blood samples from 15 subjects with CLL. Anti-CD20 targeted polyethylene glycol (PEG)-based nanoparticles had generally efficient CLL cells low phagocytosis by neutrophils monocytes. There was however substantial patient-patient variability (up 164-fold difference targeting), driven part variance pre-existing anti-PEG antibodies which reduced effects. This suggests patients lower PEG antibody levels may benefit more therapies. further exemplified antibody-functionalized doxorubicin-containing PEGylated liposomes, relatively poor high uptake (significantly correlated IgG blood) killing almost all monocytes within 24 hours. Personalized low-fouling non-PEGylated particle systems are needed realize potential chemotherapies. Overall, our tumor antibody-directed delineates limitations opportunities tumor-targeting nanomedicines.

Язык: Английский

Процитировано

0