Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfur

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Facile synthesis of the unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-propargyl β-enaminones

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A simple methodology for the synthesis of bicyclic 6,7-dihydrofuro[3,4- c ]pyridines is reported. The skeletal diversity synthesized heterobicyclic frame may present new nitrogen- and oxygen-based hybrid systems medicinal chemistry.

Язык: Английский

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Solvent-Regulated Cyclization of Arylidene Isoxazolones with Amidines for Regiodivergent Synthesis of 4- and 5-Acylimidazoles

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

N-Iodosuccinimide-promoted cascade reactions of arylidene isoxazolones with amidines in p-xylene were accomplished, affording 5-acylimidazoles good to excellent yields. Interestingly, when the performed by employing acetonitrile as solvent, 4-acylimidazoles efficiently obtained. Mechanistic studies indicate that formation imidazolyl and acyl moieties may undergo a spiroannulation-ring opening aromatization-hydrolysis reaction sequence. Based on this solvent-regulated tandem strategy, powerful protocol for switchable regiodivergent synthesis structurally diverse was successfully established.

Язык: Английский

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Vicinal diphosphorylation of enaminones with diaryl phosphine oxides via AlCl3-mediated C N bond cleavage

Tetrahedron Letters, Год журнала: 2025, Номер 158, С. 155472 - 155472

Опубликована: Фев. 20, 2025

Язык: Английский

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Bromide-catalyzed oxo-amination of alkenes towards the synthesis of α-amine ketones under photoelectrocatalysis conditions

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(13), С. 3525 - 3530

Опубликована: Янв. 1, 2024

An efficient and novel bromide-catalyzed oxo-amination of aryl alkenes towards the synthesis α-amine ketones under photoelectrocatalysis conditions was developed. The generation 2-bromo-1-phenylethanone supposed as key step.

Язык: Английский

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Electrochemical-induced solvent-tuned selective C(sp³)–H bond activation towards the synthesis of C3-functionalized chromone derivatives

Chemical Communications, Год журнала: 2024, Номер 60(38), С. 5050 - 5053

Опубликована: Янв. 1, 2024

An unprecedented solvent-tuned electrochemical method for selective C(sp

Язык: Английский

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De novo synthesis of 6-6-5 fused-systems through electrochemical decarboxylation and radical domino additions

Green Chemistry, Год журнала: 2024, Номер 26(19), С. 10308 - 10313

Опубликована: Янв. 1, 2024

An oxidant and quaternary ammonium salt-free electrosynthesis of 6-6-5 fused systems was developed with excellent atom step economy.

Язык: Английский

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Direct synthesis of Enone-Hydrazones under solvent free and additives free conditions

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A series of enone-hydrazones were synthesized through the reaction enaminones with hydrazones under solvent-free, additive-free, and metal-catalyst-free conditions.

Язык: Английский

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Dibromomethane-Triggered Electrochemical Cyclization of Enaminones with Amidines for the Synthesis of 5-Acylimidazoles

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

An electrochemical tandem cyclization of enaminones with amidines has been reported for the first time using dibromomethane as an initiating agent in undivided cell. Following this protocol, a vast variety polysubstituted 5-acylimidazoles were obtained moderate to good yields without use external oxidants. Mechanistic studies indicate that bromide anion, electroreductively generated from dibromomethane, acts redox mediator complete catalytic cycle.

Язык: Английский

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Rhodium(III)-Catalyzed Sequential Cyclization of Enaminones with 1,3-Dienes via C–H Activation for the Synthesis of Fluorenones

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

An efficient method for construction of various fluorenones has been achieved via Rh(III)-catalyzed C–H activation/[4 + 2] annulation/aromatization sequences simple and readily available enaminones 1,3-dienes. This protocol showed good substrate compatibility as an array structurally electronically diverse prepared efficiently in moderate to yields preparative scale utility showing very efficiency the late-stage functionalization complex valuable molecules.

Язык: Английский

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