COX-2-targeted fluorescent probe for ClO- monitoring in precise cancer detection

Bioorganic Chemistry, Год журнала: 2025, Номер 156, С. 108164 - 108164

Опубликована: Янв. 18, 2025

Язык: Английский

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Triphenylamine-Naphthalimide-Based “On–Off–On” AIEgen for Imaging Golgi Apparatus and Endoplasmic Reticulum

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Golgi apparatus (GA) and endoplasmic reticulum (ER) are two of the interesting subcellular organelles that critical for protein synthesis, folding, processing, post-translational modifications, secretion. Consequently, dysregulation in GA ER cross-talk between them implicated numerous diseases including cancer. As a result, simultaneous visualization cancer cells is extremely crucial developing therapeutics. To address this, herein, we have designed synthesized 1,8-napthalimide-based small molecule (AIE-GA-ER) consisting phenylsulfonamide as Golgi-ER homing triphenylamine-napthalimide aggregation-induced emission (AIE) triggering moieties. AIE-GA-ER exhibited remarkable "on-off-on" AIE properties THF/water binary solvent system due to aggregated "on-state" pure THF 80% water THF. Molecular dynamic simulations density functional theory (DFT) calculations underlying mechanism emissive property be interplay intramolecular charge transfer (ICT) stabilization aggregation THF, DMSO, water. efficiently homed into HCT-116 colon within 15-30 min well noncancerous human retinal epithelial pigment (RPE-1) 3 h with minimum toxicity. This AIEgen has potential illuminate simultaneously understand chemical biology their next-generation

Язык: Английский

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Design strategies for organelle-selective fluorescent probes: where to start?

RSC Advances, Год журнала: 2025, Номер 15(3), С. 2115 - 2131

Опубликована: Янв. 1, 2025

Advancing the development of organelle-targeted small fluorescent probes by highlighting key design strategies to reveal cellular dynamics and address persistent challenges in probe design.

Язык: Английский

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A near-infrared fluorescent probe for detecting hydrogen sulfide and its applications in monitoring food freshness and bioimaging

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112843 - 112843

Опубликована: Янв. 1, 2025

Язык: Английский

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Light-controllable enzymatic emission shift for spatiotemporal ratiometric imaging of tyrosinase activity in living cells and zebrafish

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137538 - 137538

Опубликована: Фев. 1, 2025

Язык: Английский

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A red-emitting fluorescent probe with large stokes shift for monitoring of viscosity and polarity and its application in bioimaging, distinguishing cancer cells

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141976 - 141976

Опубликована: Март 1, 2025

Язык: Английский

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Design, synthesis and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117519 - 117519

Опубликована: Март 1, 2025

Язык: Английский

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Monitoring variations in mitochondrial hydrogen sulfide using two-photon cyclometalated iridium(III) complex probe: A new strategy for ischemia-reperfusion drug discovery and efficacy evaluation

Talanta, Год журнала: 2025, Номер 292, С. 128021 - 128021

Опубликована: Март 30, 2025

Язык: Английский

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A novel photoactivatable Coumarin-based fluorescent “turn-on” probe: Synthesis and applications for H2S detection in living cells and zebrafish models

Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108447 - 108447

Опубликована: Апрель 1, 2025

Язык: Английский

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Excited-state intramolecular-proton-transfer-based fluorescent probe for the rapid detection of peroxynitrite in Alzheimer’s disease models

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер unknown, С. 126200 - 126200

Опубликована: Апрель 1, 2025

Язык: Английский

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