Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 6, 2025
To
address
the
challenges
of
limited
drug
accumulation
and
penetration
in
pancreatic
ductal
adenocarcinoma
(PDAC),
a
cascade
ultrasonic
cavitation
strategy
designed
to
enhance
delivery
by
sequentially
overcoming
biological
barriers
is
developed.
This
approach
employs
macrophage
membrane‐modified
microbubble–nanoparticle
hybrid
(MMB@TFHPD)
capable
cavitation.
MMB@TFHPD
consists
microbubble
coating
(MMB)
mesoporous
silica
core
(TFHPD),
coloaded
with
doxorubicin
perfluoropentane.
Following
intravenous
administration,
accumulates
near
tumor
endothelial
cells
via
ligand–receptor
interaction.
Low‐intensity
ultrasound
(first
US)
then
applied
induce
primary
cavitation,
disrupting
blood‐tumor
barrier
enhancing
TFHPD
NPs
accumulate
within
periphery.
Upon
exposure
acidic
microenvironment
(TME),
surface
tannic
acid–iron
complexes
(TA/Fe
3+
)
degrade,
exposing
structure.
High‐intensity
US
(second
subsequently
applied,
triggering
liquid‐to‐gas
phase
transition
PFP
microbubbles
destruction,
which
induces
extracellular
matrix
collapse,
rapid
release,
deep
into
parenchyma.
process
results
potent
antitumor
effects
PDAC
therapy.
In
summary,
this
study
introduces
promising
overcome
key
for
other
solid
tumors.
The Journal of Physical Chemistry Letters,
Год журнала:
2025,
Номер
unknown, С. 5302 - 5311
Опубликована: Май 20, 2025
Multimetallic
electrodes
are
gaining
significant
attention
due
to
their
ability
offer
diverse
electronic
configurations
and
local
lattice
distortions,
optimizing
interactions
with
reactants
intermediates.
Metal-phenolic
networks
(MPNs)
present
a
promising
solution
by
incorporating
wide
range
of
metals
ligands
enhance
specific
electrochemical
reactions.
Despite
potential,
on-substrate
synthesis
direct
application
MPNs
in
electrocatalysis
have
been
limited.
This
study
introduces
an
elegant,
feasible
strategy
for
as
the
oxygen
evolution
reaction
(OER)
catalyst
without
post-treatment
systematically
evaluates
metal
ion
effect
leveraging
multimetallic
doping
strategy.
Notably,
trimetallic
complex
performs
unambiguously
better
than
bimetallic
monometallic
counterparts.
TA-CoNiFe@NF
demonstrated
superior
OER
performance,
impressive
overpotential
215
mV
at
10
mA·cm-2,
Tafel
slope
37.3
mV·dec-1,
excellent
stability
over
100
h.
The
computational
results
illustrate
on
mechanism.
We
demonstrate
that
phenolic
unique
benefits
compared
MOFs,
alloys,
or
oxide
hybrids,
enabling
facile
on-surface
coordination
versatile
incorporation.
effective,
approach
tuning
paves
way
high-performance
electrocatalyst
designs
synthesis.
