Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
The
exploration
of
the
multi-dimensional
brain
activity
with
high
temporal
resolution
and
spatial
is
great
significance
in
diagnosis
neurological
disease
study
science.
Although
integration
EEG
magnetic
resonance
imaging
(MRI)
computed
tomography
(CT)
provides
a
potential
solution
to
achieve
brain-functional
image
spatiotemporal
resolution,
critical
issues
interface
stability
compatibility
remain
challenges.
Therefore,
this
research,
we
proposed
conductive
hydrogel
electrode
an
asymmetrical
bilayer
structure,
which
shows
overcome
Benefited
from
structure
different
moduli,
exhibits
biological
mechanical
heterogeneous
brain-electrode
interface.
As
result,
impedance
can
be
reduced
compared
conventional
metal
electrodes.
In
addition,
hydrogel-based
ionic
electrodes,
are
free
conductors,
compatible
MRI
CT.
it
obtain
information
clinical
settings.
research
outcome
new
approach
for
establishing
platform
early
diseases
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 5, 2025
Photoacoustic
brain
imaging
(PABI)
has
emerged
as
a
promising
biomedical
modality,
combining
high
contrast
of
optical
with
deep
tissue
penetration
ultrasound
imaging.
This
review
explores
the
application
photoacoustic
in
tumor
imaging,
highlighting
synergy
between
nanomaterials
and
state
art
techniques
to
achieve
high-resolution
deeper
tissues.
PABI
leverages
effect,
where
absorbed
light
energy
causes
thermoelastic
expansion,
generating
waves
that
are
detected
converted
into
images.
technique
enables
precise
diagnosis,
therapy
monitoring,
enhanced
clinical
screening,
specifically
management
complex
diseases
such
breast
cancer,
lymphatic
disorder,
neurological
conditions.
Despite
integration
agents
radiation,
providing
comprehensive
overview
current
methodologies,
major
obstacles
treatment,
future
directions
for
improving
diagnostic
therapeutic
outcomes.
The
underscores
significance
robust
research
tool
medical
method,
potential
revolutionize
disease
diagnosis
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
Organic
photothermal
materials
have
attracted
extensive
attention
due
to
their
designable
molecular
structure,
tunable
excited‐state
properties,
and
excellent
biocompatibility,
however,
the
development
of
near‐infrared
II
(NIR‐II)
absorbing
organic
with
high
conversion
efficiency
(PTCE)
molar
extinction
coefficient
(
ɛ
)
remains
challenging.
Herein,
a
novel
“electron‐donor
iteration”
strategy
is
proposed
construct
dendrimers
(CR‐DPA‐T,
CR‐(DPA)
2
‐T
3
‐T)
donor‐
π
‐acceptor‐
‐donor
(D
‐π‐
A‐
‐D)
features
diradical
characteristics.
Owing
enhanced
D–A
effect
intramolecular
motions,
absorption
capacity
increase
as
generation
grows.
Surprisingly,
an
performance
1064
×
PTCE
superb
value
2.85
10
4
in
NIR‐II
region
achieved
for
nanoparticles
(CR‐(DPA)
NPs)
compared
most
reported
counterparts.
Besides,
NPs
exhibit
superior
antitumor
efficacy
by
synergistic
therapy
(PTT)
immunotherapy,
efficiently
inhibiting
growth
both
primary
distant
tumors.
To
best
knowledge,
dendrimer
first
time
reported,
universal
donor
engineering
offered
develop
NIR‐II‐absorbing
immunotherapy.
Beilstein Journal of Nanotechnology,
Год журнала:
2025,
Номер
16, С. 195 - 215
Опубликована: Фев. 17, 2025
The
human
eye,
with
its
remarkable
resolution
of
up
to
576
million
pixels,
grants
us
the
ability
perceive
world
astonishing
accuracy.
Despite
this,
over
2
billion
people
globally
suffer
from
visual
impairments
or
blindness,
primarily
because
limitations
current
ophthalmic
treatment
technologies.
This
underscores
an
urgent
need
for
more
advanced
therapeutic
approaches
effectively
halt
even
reverse
progression
eye
diseases.
rapid
advancement
nanotechnology
offers
promising
pathways
development
novel
therapies.
Notably,
photothermal
nanomaterials,
particularly
well-suited
transparent
tissues
have
emerged
as
a
potential
game
changer.
These
materials
enable
precise
and
controllable
therapy
by
manipulating
distribution
thermal
field.
Moreover,
they
extend
beyond
conventional
boundaries
therapy,
achieving
unparalleled
effects
through
their
diverse
composite
structures
demonstrating
enormous
in
promoting
retinal
drug
delivery
photoacoustic
imaging.
paper
provides
comprehensive
summary
structure-activity
relationship
between
properties
these
nanomaterials
innovative
mechanisms.
We
review
latest
research
on
nanomaterial-based
treatments
various
Additionally,
we
discuss
challenges
future
perspectives
this
field,
focus
enhancing
global
health.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Despite
the
development
of
various
medical
imaging
contrast
agents,
integrating
signal
generation
with
therapeutic
and
microrobotic
functions
remains
challenging
without
complicated
fabrication
processes.
In
this
study,
upconversion
nanoparticle-covalent
organic
framework
(UCNP-COF)
core-shell
sub-micron
particles
are
developed
that
function
as
microrobots
trackable
multi-spectral
optoacoustic
tomography
(MSOT)
can
be
loaded
desired
molecular
agents
in
a
customizable
manner.
The
mechanism
UCNP-COF
is
attributed
to
quenching
luminescence
emitted
by
UCNPs,
which
absorbed
encapsulating
COF
subsequently
converted
into
acoustic
waves.
Unlike
other
microparticulate
previously
imaged
MSOT,
do
not
pose
concerns
about
their
stability
biocompatibility.
Simultaneously,
mesoporous
texture
provides
large
surface
area,
allowing
for
efficient
loading
drug
molecules,
released
at
target
sites.
Furthermore,
magnetic
Janus
magnetically
navigated
through
vivo
vasculature
while
being
visualized
real-time
volumetric
MSOT.
This
study
proposes
an
approach
design
photonic
materials
multifunctionality,
enabling
high-performance
imaging,
delivery,
manipulation
toward
future
potential
clinical
use.
Applied Physics Letters,
Год журнала:
2024,
Номер
125(3)
Опубликована: Июль 15, 2024
Endoscopy,
enabling
high-resolution
imaging
of
deep
tissues
and
internal
organs,
plays
an
important
role
in
basic
research
clinical
practice.
Recent
advances
photoacoustic
microscopy
(PAM),
demonstrating
excellent
capabilities
functional
imaging,
have
sparked
significant
interest
its
integration
into
the
field
endoscopy.
However,
there
are
challenges
achieving
PAM
endoscopic
setting.
This
Perspective
article
discusses
current
progress
development
related
to
measurements.
Then,
it
points
out
potential
directions
advance
for
by
leveraging
fiber
optics,
microfabrication,
optical
engineering,
computational
approaches.
Finally,
highlights
emerging
opportunities
translational
biomedicine.
Bioengineering & Translational Medicine,
Год журнала:
2025,
Номер
10(3)
Опубликована: Фев. 4, 2025
The
detection
and
complete
eradication
of
early-stage
small
tumors
during
hysteroscopy
remains
a
significant
clinical
challenge
in
preserving
fertility
for
young
women
with
endometrial
cancer
(EC).
purpose
this
study
is
to
verify
the
feasibility
CD47
as
an
optical
molecular
imaging
(OMI)
target
human
EC
achieve
precise
localization
identification
hysteroscopic
surgery.
results
demonstrated
that
was
overexpressed
through
bioinformatics,
immunohistochemistry,
qRT-PCR.
In
cell
lines,
CD47-targeted
near-infrared
photoimmunotherapy
(NIR-PIT)
induced
cytotoxicity
light
dose-dependent
manner.
Laser
confocal
microscopy
revealed
intervention
significantly
increased
phagocytic
effect
macrophages
on
cells.
mice
model
partial
tumor
resection
mediated
by
OMI,
compared
group
A
(immune
therapy
alone),
C
(NIR-PIT
treatment)
showed
reduced
recurrence
rate
after
NIR-PIT
intervention.
However,
difference
did
not
reach
statistical
significance.
We
then
evaluated
maintenance
mice.
indicated
that,
untreated
animals,
growth
slower
using
CD47-Alexa
Fluor
790
(CD47-AF790),
allowing
more
sustained
control.
freshly
isolated
whole
uterus
specimens
from
patients
were
co-incubated
CD47-AF790,
enhanced
contrast
NIR
visible
images
tissue
observed,
demonstrating
high
sensitivity
specificity
(tumor-to-background
ratio
>5.05).
Finally,
under
fluorescence
microscopy,
specific
fluorescent
signals
are
observed
conclusion,
accurate
excision
can
be
accomplished
employing
agents
OMI
technology.
This
method
shows
potential
viable
promising
approach
diagnosis
EC.
