Combining Liposomal Photocatalysts with Whole‐Cell Catalysts for One‐pot Photobiocatalysis

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Abstract Cooperative photobiocatalytic processes have seen extensive potentials for the synthesis of both bulk and fine chemicals owing to their versatility, eco‐friendliness, cost‐effectiveness. Nevertheless, developing a universal effective synthetic strategy compatible with catalytic systems remains challenging. In this study, we explored cationic liposomes as biocompatible photocatalyst encapsulation combined them bacteria overexpressing enzymes two‐step three‐step cascade reactions. Specifically, water‐soluble anthraquinone‐2‐sulfonate (AQS), which can oxidize benzyl alcohol, is encapsulated within core composed dioleoyl‐3‐trimethylammonium propane (DOTAP) helper lipid cholesterol. The positive charge on liposome surface enabled electrostatic interactions negative charges membrane Escherichia coli cells. Bacterial cells various enzymes, such Candida antarctica lipase B (CalB) benzaldehyde lyase (BAL), coated production added value compounds through reactions excellent production. These cascades involve CalB‐catalyzed hydrolysis, BAL‐catalyzed condensation, AQS‐driven photo‐oxidation Therefore, offers more possibilities combining photocatalysis biocatalysis recoverability, enhanced mass transfer, compatibility in industrial biotechnology chemistry.

Язык: Английский

Efficient Chemoenzymatic Cascade Reaction for One-Pot Enantioselective Synthesis of Chiral Indole Derivatives in Water

Опубликована: Янв. 1, 2024

Язык: Английский