Spherical-shaped ZnO nanoparticles and their diverse surface morphological applications in various biological applications against ROS DOI
Pramod Kumar, Ranganathan Babujanarthanam, R. Tamil Selvi

и другие.

Applied Physics A, Год журнала: 2025, Номер 131(5)

Опубликована: Апрель 18, 2025

Язык: Английский

Microbially synthesized nanomaterials: Advances and applications in biomedicine DOI Creative Commons
Junjie Pan, Hong Qian, Ya‐Yen Sun

и другие.

Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100019 - 100019

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Cyborg microbe biohybrids with metal–organic coating layers: strategies, functionalisation and potential applications DOI Creative Commons
Zichen Wu, Ke Xu,

Regina Huang

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101642 - 101642

Опубликована: Март 7, 2025

The integration of living microbes, specifically bacteria and fungi, with metal-organic nanocoatings has led to the recent development cyborg microbe biohybrids, which show excellent adaptability functionality for a wide range potential applications in biotechnology medicine. This review discusses strategies, functionalisation, these are categorised into two types coatings: frameworks (MOFs) metal-phenolic networks (MPNs). Key advances their synthetic approaches via in-situ pre-synthesised coatings crucially addressed, yet methodology details specific advantages highlighted. Despite notable advancements, there various limitations challenges, such as determination long-term viability stability insufficient work on theranostic essentially scaling-up difficulties industrial clinical translation. latest advancements biohybrids related technology have established critical foundation enhancing innovative studies through strong interdisciplinary teamwork.

Язык: Английский

Процитировано

1
Engineering live cell surfaces with polyphenol-functionalized nanoarchitectures DOI Creative Commons
Yunxiang He, Qinling Liu,

Yuanmeng He

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Polyphenol-functionalized nanoarchitectures (cytoPNAs) provide a modular and cell independent strategy to create biohybrids for engineering, with improved production biomanufacturing enhanced efficacy cell-based therapies.

Язык: Английский

Процитировано

0
Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis DOI
Huan Yang, Xu Zhang,

Jianshuang Wu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Inflammatory bowel disease (IBD) is a complex chronic intestinal disorder in which excessive oxidative stress, dysregulated immune response, and microbiota dysbiosis contribute to recurrent episodes of inflammation the colonic mucosa. Current clinical treatments focusing solely on resolution often exhibit limited efficacy due inability fundamentally improve pathological microenvironment. Herein, probiotic membrane-modified drug delivery nanocomposite, namely, MPDA@Cur@EM, developed for comprehensive treatment IBD. It contains two components: curcumin-loaded mesoporous polydopamine nanoparticle (MPDA@Cur) as core Escherichia coli Nissle 1917 outer membrane (EM) surface. For MPDA@Cur, microenvironment triggers responsive release curcumin. Importantly, MPDA@Cur can effectively alleviate inflammatory response LPS-activated macrophages through MPDA-mediated ROS scavenging curcumin-induced M2 polarization. In dextran sulfate sodium (DSS)-induced colitis model, EM coating not only allows targeting enrichment orally administered MPDA@Cur@EM inflamed mucosa, but also participates regulation flora. Consequently, efficiently attenuates reaction restores barrier functions, demonstrated by multipronged manner restoring redox balance, remodeling homeostasis, reshaping gut microecology. Collectively, this work provides safe promising codelivery strategy product, antioxidative nanoenzyme, therapeutic management

Язык: Английский

Процитировано

0
Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges DOI Creative Commons

Krupansh Desai,

Joëlle Mekontso,

Ketaki Deshpande

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Living Therapeutic Materials represent a promising technology to tackle therapeutic problems that classical materials cannot address. Despite the advancements on new functions of these devices, applications, and fabrication methods, preclinical evaluation is still very limited challenges appear when incorporating living devices in contact with host. This critical bottleneck path translation clinic. Therefore, we have compiled literature Materials, focus microorganism-based materials, summarized investigations carried out assess their biocompatibility, safety, efficacy. We split three parts: vitro, ex vivo, vivo assessments, where describe common practices remaining challenges.

Язык: Английский

Процитировано

0
Targeting breast cancer: the promise of phage-based nanomedicines DOI

Sarah Gholami,

Hossein Saffarfar,

Mohammad Reza Mehraban

и другие.

Breast Cancer Research and Treatment, Год журнала: 2025, Номер 211(3), С. 561 - 580

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Spherical-shaped ZnO nanoparticles and their diverse surface morphological applications in various biological applications against ROS DOI
Pramod Kumar, Ranganathan Babujanarthanam, R. Tamil Selvi

и другие.

Applied Physics A, Год журнала: 2025, Номер 131(5)

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

0