Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Clinical
immune
checkpoint
blockade
(ICB)‐based
immunotherapy
of
malignant
tumors
only
elicits
durable
responses
in
a
minority
patients,
primarily
due
to
the
highly
immunosuppressive
tumor
microenvironment.
Although
inducing
immunogenic
cell
death
(ICD)
through
reactive
oxygen
biocatalyst
represents
an
attractive
therapeutic
strategy
amplify
ICB,
currently
reported
biocatalysts
encounter
insurmountable
challenges
achieving
high
ROS‐generating
activity
induce
potent
ICD.
Here,
inspired
by
natural
catalytic
characteristics
NADPH
oxidases,
design
efficient,
robust,
and
electron‐rich
Pt‐based
redox
centers
on
non‐stoichiometric
W
18
O
49
substrates
(Pt─WO
x
)
serve
as
bioinspired
potently
activate
ICD,
which
eventually
enhance
cancer
amplifies
ICB‐based
is
reported.
These
studies
demonstrate
that
Pt─WO
exhibits
rapid
electron
transfer
capability
can
promote
formation
low
oxophilic
Pt
for
superior
biocatalysis,
enables
‐based
inducers
trigger
endoplasmic
reticulum
stress
directly
stimulate
amplifying
anti‐PD‐L1‐based
ICB
therapy.
This
provides
straightforward
engineer
also
opens
up
new
avenue
create
efficient
ICD
primary/metastatic
treatments.
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(3), С. 9 - 18
Опубликована: Март 14, 2025
With
previously
unheard-of
improvements
in
cancer
detection,
therapy,
and
monitoring,
nano-engineering
has
become
a
game-changer
precision
oncology.
Researchers
can
create
nanoscale
drug
delivery
systems
that
maximize
therapeutic
efficacy
reduce
systemic
toxicity
by
utilizing
nanotechnology.
an
emphasis
on
targeted
delivery,
tumor
microenvironment
manipulation,
nanocarrier-mediated
immunotherapy,
this
study
investigates
the
molecular
processes
underlying
nano-engineered
therapeutics.
By
increasing
specificity
lowering
side
effects,
innovations
including
photothermal
photodynamic
biomimetic
nanostructures,
nanoparticle-based
CRISPR
gene
editing
are
transforming
treatment
of
cancer.
Furthermore,
real-time,
non-invasive
detection
monitoring
made
possible
liquid
biopsy
technologies
nano-biosensors,
allowing
for
early
intervention
individualized
plans.
A
comprehensive
approach
to
management
is
provided
interaction
nanotechnology
oncology,
which
also
makes
it
easier
multipurpose
nanoplatforms
combine
diagnosis
(theranostics).
Nano-engineering
enormous
promise
overcome
resistance,
improve
immune
system
engagement,
enable
precision-targeted
treatments
as
oncology
develops.
To
clinical
translation,
however,
issues
biocompatibility,
large-scale
production,
regulatory
permissions
need
be
resolved.
focus
its
role
developing
ground-breaking
changing
face
focuses
recent
advances,
present
difficulties,
potential
future
paths
therapy.
RSC Advances,
Год журнала:
2025,
Номер
15(15), С. 11893 - 11901
Опубликована: Янв. 1, 2025
A
novel
nanocatalyst
based
on
Cu/Au-doped
polypyrrole
has
been
synthesized
for
NIR
II
laser-promoted
nanocatalytic
tumor
therapy
through
several
enhanced
catalytic
mechanisms,
including
elevated
temperature
and
electron
migration.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Abstract
Cold
temperatures
exhibit
a
broader
safety
margin
than
hyperthermia,
thereby
enhancing
their
controllability
and
compatibility
within
biological
systems.
Nanomaterials
with
diverse
structures
rich
functionalities
can
respond
to
cold
temperatures,
converting
physical
signals
from
environments
into
actionable
effects.
The
advancement
of
nanomaterials
nanotechnology
has
expanded
the
impact
on
systems,
fostering
emergence
cryomedicine
as
multidisciplinary
field.
In
this
review,
temperature‐responsive
are
categorized
thermally
conductive
nanomaterials,
phase‐change
temperature‐sensitive
polymer
pyroelectric
thermoelectric
nanomaterials.
methods
devices
for
applying
summarized,
emphasis
intelligent
temperature
equipment.
Furthermore,
biomedical
applications
summarized
discussed,
including
cryoablation,
drug
delivery,
cell
cryopreservation,
catalytic
therapy,
antimicrobial
biosensing,
electronic
skin.
Finally,
perspectives
challenges
potential
solutions
in
biomedicine
provided,
aiming
offer
insights
cryomedicine.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Clinical
immune
checkpoint
blockade
(ICB)‐based
immunotherapy
of
malignant
tumors
only
elicits
durable
responses
in
a
minority
patients,
primarily
due
to
the
highly
immunosuppressive
tumor
microenvironment.
Although
inducing
immunogenic
cell
death
(ICD)
through
reactive
oxygen
biocatalyst
represents
an
attractive
therapeutic
strategy
amplify
ICB,
currently
reported
biocatalysts
encounter
insurmountable
challenges
achieving
high
ROS‐generating
activity
induce
potent
ICD.
Here,
inspired
by
natural
catalytic
characteristics
NADPH
oxidases,
design
efficient,
robust,
and
electron‐rich
Pt‐based
redox
centers
on
non‐stoichiometric
W
18
O
49
substrates
(Pt─WO
x
)
serve
as
bioinspired
potently
activate
ICD,
which
eventually
enhance
cancer
amplifies
ICB‐based
is
reported.
These
studies
demonstrate
that
Pt─WO
exhibits
rapid
electron
transfer
capability
can
promote
formation
low
oxophilic
Pt
for
superior
biocatalysis,
enables
‐based
inducers
trigger
endoplasmic
reticulum
stress
directly
stimulate
amplifying
anti‐PD‐L1‐based
ICB
therapy.
This
provides
straightforward
engineer
also
opens
up
new
avenue
create
efficient
ICD
primary/metastatic
treatments.
