Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(42)
Опубликована: Май 28, 2024
Abstract
Excited‐state
intramolecular
proton
transfer
(ESIPT)
molecules,
which
feature
large
Stokes
shifts
to
avoid
self‐absorption,
play
an
essential
role
in
photoluminescent
bioimaging
probes.
Herein,
we
report
the
development
of
ESIPT
molecule
3‐(3‐hydroxypyridin‐2‐yl)isoquinolin‐4‐ol
(
PiQ
).
not
only
undergoes
a
distinct
process
unlike
symmetrical
2,2′‐bipyridyl‐3,3′‐diol
but
also
exhibits
aggregation‐induced
emission
(AIE)
characteristics.
self‐assembles
into
aggregates
with
average
size
241.0±51.9
nm
aqueous
solutions,
leading
significantly
enhanced
photoluminescence.
On
basis
and
AIE
characteristics
,
latter
is
functionalized
hydrogen
peroxide‐responsive
4‐pinacoratoborylbenzyl
group
B
)
carboxylesterase‐responsive
acetyl
A
produce
probe
B−PiQ−A
.
The
potential
for
applications
chemical
sensing
underscored
by
its
efficient
detection
both
endogenous
exogenous
peroxide
living
cells.
Abstract
Antimicrobial
resistance
caused
by
overuse
of
antibiotics
has
promoted
the
demand
for
effective
antibacterial
materials.
However,
development
existing
strategies
mostly
focuses
on
direct
sterilization,
which
may
lead
to
flora
imbalance
and
drug
resistance.
Here,
a
series
peptide‐based
aggregation‐induced
emssion
nanomaterials
(PBANs)
with
multiple
structural
domains
were
designed
mimicking
self‐assembly
human
α‐defensin
6.
Specifically,
PBANs
self‐assemble
form
nanoparticles
in
physiological
environments
situ
transform
into
nanofibers
bacterial
surfaces
through
receptor‐ligand
interactions
infected
microenvironments,
resulting
enhanced
fluorescence
signal
activation
functions,
while
labeling
entrapping
bacteria.
Different
from
traditional
that
directly
kill
pathogenic
microorganisms,
can
inhibit
motility
invasion
host
system
physical
barriers
affecting
energy
metabolism
pathways.
In
addition,
further
recruit
macrophages
infection
site
engulf
entrapped
bacteria,
thereby
synergistically
reducing
efficiency.
mouse
piglet
systemic
models,
showed
favorable
therapeutic
efficacy,
significantly
load
levels
inflammation
factors.
Overall,
this
study
provides
perspectives
developing
biomimetic
stimuli‐responsive
combat
infections.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 27, 2025
Head
and
neck
cancer
(HNC)
critically
affects
patient
survival
quality
of
life,
highlighting
the
need
for
optimized
perioperative
interventions.
While
conventional
therapies
face
limitations
in
specificity
toxicity,
nanotechnology
has
emerged
as
a
revolutionary
approach.
Preoperative
application
tumor-targeting
nanoprobes
enables
molecular-level
lesion
identification
via
biomarker-specific
conjugation
spatially
resolved
fluorescence
quantification.
Intraoperatively,
fluorescent
nanomaterials
enhance
surgical
precision
through
selective
tumor
accumulation,
delineating
malignant
margins
real
time.
Postoperatively,
engineered
nanocarriers
improve
therapeutic
outcomes
by
delivering
drugs
with
spatial
control,
minimizing
off-target
effects,
enabling
multimodal
synergies.
These
nanotechnology-driven
strategies
collectively
address
critical
challenges
HNC
management,
including
diagnostic
sensitivity,
intraoperative
visualization,
postoperative
recurrence.
Their
inherent
advantages—precision
targeting,
reduced
systemic
multifunctional
integration—establish
them
cornerstone
tools
modern
oncology.
Future
advancements
nanomaterial
design
biocompatibility
are
poised
to
further
refine
efficacy,
rates,
patient-centered
outcomes.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
selective
functionalization
of
inert
B–H
bonds
in
carborane
clusters
has
been
a
formidable
challenge.
Recent
advances
have
witnessed
such
reactions
through
photoredox
methods
utilizing
ultraviolet
or
visible
light
irradiation.
However,
high-energy
sources
often
suffer
from
poor
energy
efficiency,
limited
substrate
scope,
undesired
side
reactions,
and
low
scalability.
Here,
we
present
the
first
successful
bond
under
low-energy
near-infrared
(NIR)
using
carborane-based
electron
donor–acceptor
complex.
Both
photophysical
investigations
theoretical
modeling
reveal
facile
single-electron
transfer
cage
to
electron-deficient
photocatalyst,
generating
radical
NIR
follow-up
pathway
enables
direct
coupling
carboranes
with
amino
acids
oligopeptides,
yielding
diverse
array
carborane-functionalized
oligopeptides.
Beyond
expanding
known
chemical
space
boron
cluster
derivatives,
further
demonstrate
that
imaging
targeting
capabilities
could
serve
as
promising
multifunctional
carriers
for
neutron
capture
therapy.
Thus,
via
not
only
provides
straightforward
practical
strategy
synthetic
chemistry
but
also
lays
foundation
development
next-generation
boron-containing
biomolecules
advanced
functional
materials.
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1719 - 1719
Опубликована: Апрель 11, 2025
Since
the
discovery
of
aggregation-induced
emission
(AIE)
phenomenon,
various
stimuli-responsive
materials
have
been
rapidly
developed.
However,
how
to
achieve
transition
between
aggregation-caused
quenching
(ACQ)
and
AIE
through
molecular
design
is
an
urgent
problem
be
solved.
In
this
work,
we
synthesized
studied
aggregation
luminescence
behavior
photochromism
two
different
substituted
pyrene
ethylene
derivatives,
1-H
1-CN.
Due
substituents
attached
unit,
exhibits
ACQ
behavior.
When
substituent
a
cyanide
group,
it
addition,
ordered
nanoparticles
formed
by
self-assembly
in
aqueous
solution
exhibit
interesting
photo-induced
cyclization
behavior,
which
leads
fluorescence
under
ultraviolet
light
irradiation
(λ
=
365
nm).
Therefore,
due
their
amphiphilicity
photo-responsiveness,
these
compounds
can
used
as
anticounterfeiting
inks
information
encryption.
This
work
contributes
new
members
family
amphiphilic
photo-responsive
demonstrates
potential
applications
optical
storage
multi-color
luminescence.
Integrating
deep
learning
with
fluid
dynamics
presents
a
promising
path
for
advancing
the
comprehension
of
complex
flow
phenomena
within
both
theoretical
and
practical
engineering
domains.
Despite
this
potential,
considerable
challenges
persist,
particularly
regarding
calibration
training
models.
This
paper
conducts
an
extensive
review
analysis
recent
developments
in
architectures
that
aim
to
enhance
accuracy
data
interpretation.
It
investigates
various
applications,
architectural
designs,
performance
evaluation
metrics.
The
covers
several
models,
including
convolutional
neural
networks,
generative
adversarial
physics-informed
transformer
diffusion
reinforcement
frameworks,
emphasizing
components
improving
reconstruction
capabilities.
Standard
metrics
are
employed
rigorously
evaluate
models'
reliability
efficacy
producing
high-performance
results
applicable
across
spatiotemporal
data.
findings
emphasize
essential
role
representing
flows
address
ongoing
related
systems'
high
degrees
freedom,
precision
demands,
resilience
error.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Abstract
This
study
reports
the
synthesis
and
characterization
of
novel
thiophene‐based
multilayer
3D
chiral
polymers
incorporating
methoxy
octyloxy
functional
groups.
These
exhibit
unique
fluorescence
properties,
including
a
pronounced
aggregation‐induced
emission
(AIE)
phenomenon
at
lower
excitation
wavelength
than
previously
reported
thiophene
systems.
Additionally,
demonstrate
remarkable
sensitivity
in
detecting
hexavalent
chromium
ions
(Cr
6+
),
significant
environmental
pollutant.
The
interaction
between
Cr
leads
to
measurable
changes
fluorescence,
highlighting
their
potential
for
applications
monitoring
biosensing.
Importantly,
these
are
effective
actual
water,
where
they
maintain
selectivity
despite
presence
competing
metal
ions.
enhanced
further
underscores
suitability
real‐world
applications.
work
contributes
field
emphasizes
versatility
advanced
sensing
The Journal of Physical Chemistry Letters,
Год журнала:
2024,
Номер
15(43), С. 10866 - 10872
Опубликована: Окт. 23, 2024
Most
of
the
traditional
fluorescent
molecules
have
advantages
high
fluorescence
quantum
yield,
good
stability,
and
excellent
structural
adjustability,
but
they
exhibit
characteristics
quenching
caused
by
aggregation,
which
restricts
their
application
in
aqueous
solutions
or
solids.
The
luminescence
properties
photosensitive
potential
aggregation-induced
emission
(AIE)
materials
a
condensed
state
made
them
widely
concerned
scientific
research
field,
so
it
is
very
challenging
to
regulate
transformation
aggregation-caused
(ACQ)
fluorophores
into
AIE
fluorophores.
In
this
study,
coumarin
fluorophore
was
used
as
matrix.
After
conjugating
triphenylamine
group,
triphenylphosphine
cation
linked
through
alkyl
chain
obtain
molecular
probe
NCTPP
with
characteristic,
water
solubility,
mitochondrial
green
light
imaging,
chemotherapy
photodynamic
therapy
capabilities.
As
far
we
know,
first
time
that
photosensitivity
imparted
ACQ-AIE
conversion
method.
