Langmuir,
Год журнала:
2024,
Номер
40(31), С. 16145 - 16150
Опубликована: Июль 26, 2024
As
a
common
pathological
hallmark,
protein
aggregation
into
amyloids
is
highly
complicated
phenomenon,
attracting
extensive
research
interest
for
elucidating
its
structural
details
and
formation
mechanisms.
Membrane
deposition
disulfide-driven
misfolding
play
critical
roles
in
amyloid-type
aggregation,
yet
the
underlying
molecular
process
remains
unclear.
Here,
we
employed
sum
frequency
generation
(SFG)
vibrational
spectroscopy
to
comprehensively
investigate
remodeling
of
lysozyme,
as
model
protein,
aggregates
at
cell
membrane
interface.
It
was
discovered
that
disulfide
reduction
concurrently
induced
transition
membrane-bound
lysozyme
from
predominantly
α-helical
antiparallel
β-sheet
structures,
under
mode
switch
interaction
electrostatic
hydrophobic,
subsequent
oligomeric
aggregation.
These
findings
shed
light
on
systematic
understanding
dynamic
mechanisms
membrane-interactive
amyloid
oligomer
formation.
Porous
aromatic
frameworks
(PAFs)
are
a
fundamental
group
of
porous
materials
characterized
by
their
distinct
structural
features
and
large
surface
areas.
These
synthesized
from
building
units
linked
strong
carbon–carbon
bonds,
which
confer
exceptional
rigidity
long-term
stability.
PAFs
functionalities
may
arise
directly
the
intrinsic
chemistry
or
through
postmodification
motifs
using
well-defined
chemical
processes.
Compared
to
other
traditional
such
as
zeolites
metallic-organic
frameworks,
demonstrate
superior
stability
under
severe
treatments
due
robust
bonding.
Even
in
challenging
environments,
ease
functionalization
flexibility
specificity.
Research
on
has
significantly
expanded
accelerated
over
past
decade,
necessitating
comprehensive
overview
key
advancements
this
field.
This
review
provides
an
in-depth
analysis
recent
advances
synthesis,
functionalization,
dimensionality
PAFs,
along
with
distinctive
properties
wide-ranging
applications.
explores
innovative
methodologies
strategies
for
functionalizing
structures,
manipulation
tailor
specific
potential
Similarly,
application
areas,
including
batteries,
absorption,
sensors,
CO2
capture,
photo-/electrocatalytic
usages,
supercapacitors,
separation,
biomedical
discussed
detail,
highlighting
versatility
addressing
modern
scientific
industrial
challenges.
Coatings,
Год журнала:
2024,
Номер
14(3), С. 256 - 256
Опубликована: Фев. 21, 2024
During
surgery
and
after,
pathogens
can
contaminate
indwelling
implanted
medical
devices,
resulting
in
serious
infections.
Microbial
colonization,
infection,
later
biofilm
formation
are
major
complications
associated
with
the
use
of
implants
represent
risk
factors
implant
failure.
Despite
fact
that
aseptic
antimicrobial
medications
lower
systemic
antibiotic
result
a
loss
efficacy,
increased
tissue
toxicity,
development
drug-resistant
diseases.
This
work
explores
advancements
coatings
for
head-related
implantable
addressing
critical
issue
infection
prevention.
It
emphasizes
significance
these
reducing
microbial
colonization
highlights
various
techniques
materials
used
creating
effective
surfaces.
Moreover,
this
article
presents
comprehensive
overview
current
strategies
future
directions
coating
research,
aiming
to
improve
patient
outcomes
by
preventing
implant-associated
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
685, С. 350 - 360
Опубликована: Янв. 19, 2025
Unwanted
nonspecific
adsorption
caused
by
biomolecules
influences
the
lifetime
of
biomedical
devices
and
sensing
performance
biosensors.
Previously,
we
have
designed
B-M-E
triblock
proteins
that
rapidly
assemble
on
inorganic
surfaces
(gold
silica)
render
those
antifouling.
The
a
surface-binding
domain
B,
multimerization
M
an
antifouling
E.
Many
technologies
involve
organic
(polymeric)
where
could
potentially
be
used.
In
this
study,
computationally
experimentally
investigate
assembly
polystyrene
(PS)
surfaces,
using
PS-binding
peptides
as
block
B.
We
used
atomic
force
microscopy,
dynamic
light
scattering,
fluorescence
microscopy
quartz
crystal
microbalance
to
test
coating
functionality.
found
that,
like
for
with
B
block,
form
homogeneous
monomolecular
layers
PS
good
stability
against
PBS
washing.
adsorbed
protein
layer
fully
prevents
fluorescently
labeled
bovine
serum
albumin
microfluidic
chips.
Similarly,
no
significant
fouling
was
observed
when
1
%
(v/v)
or
10
human
were
foulants.
Journal of Inorganic and Organometallic Polymers and Materials,
Год журнала:
2024,
Номер
34(7), С. 2926 - 2947
Опубликована: Апрель 16, 2024
Abstract
The
characteristic
feature
of
a
biofunctional
system
is
that
components
with
various
functions
work
together.
These
multi-components
are
not
simply
mixed
together,
but
rationally
arranged.
fundamental
technologies
to
do
this
in
an
artificial
include
the
synthetic
chemistry
substances
make
component
unit,
science
and
techniques
for
assembling
them,
technology
analyzing
their
nanoostructures.
A
new
concept,
nanoarchitectonics,
can
play
role.
Nanoarchitectonics
post-nanotechnology
concept
involves
building
functional
materials
reflect
nanostructures.
In
particular,
approach
combining
multiple
types
create
composite
area
where
nanoarchitectonics
be
powerful
tool.
This
review
summarizes
such
examples
related
studies.
presented
areas
catalyst
&
photocatalyst,
energy,
sensing
environment,
bio
medical,
other
applications
illustrate
potential
wide
range
applications.
order
show
stages
development,
only
state-of-the-art,
also
those
successful
developments
existing
research.
Finally,
summary
brief
discussion
future
challenges
will
given.
applicable
all
aims
establish
ultimate
methodology
science.
Advanced Materials,
Год журнала:
2024,
Номер
36(47)
Опубликована: Сен. 30, 2024
Abstract
Minimally
invasive
blood‐contacting
interventional
devices
are
increasingly
used
to
treat
cardiovascular
diseases.
However,
the
risk
of
device‐related
thrombosis
remains
a
significant
concern,
particularly
formation
cycling
thrombi,
which
pose
life‐threatening
risks.
To
better
understand
interactions
between
these
and
blood,
initial
stages
coagulation
contact
activation
on
extrinsic
surfaces
investigated.
Direct
force
measurements
reveals
that
activated
factors
stimulate
intrinsic
pathway
promote
surface
crosslinking
fibrin.
Furthermore,
fibrin
aggregation
is
disrupted
by
surface‐grafted
inhibitors,
as
confirmed
ex
vivo
tests.
An
engineered
serum
protein
with
zwitterion
grafts
resist
deposition
biological
species
such
fibrin,
platelets,
red
blood
cells
also
developed.
Simultaneously,
protease
inhibitor‐based
coacervate
incorporated
into
coating
inhibit
effectively.
The
loaded
can
be
released
reloaded
through
modulation
catechol‐amine
interactions,
facilitating
material
regeneration.
strategy
offers
novel
multi‐scale
mediation
simultaneously
inhibits
nanoscale
resists
microscale
thrombus
aggregation,
providing
long‐term
solution
for
anticoagulation
in
devices.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Abstract
3D
printing
of
protein
materials
for
creating
bioactive
scaffolds
has
attracted
significant
interest.
However,
achieving
controllable
and
stable
while
replicating
the
ordered
structure
found
in
natural
remains
a
key
challenge.
Herein,
universally
applicable
temperature‐dependent
aggregation
(TPA)
strategy
is
reported
to
manipulate
unfolding,
relaxation,
reorganization
chains
enable
amyloid‐like
proteins.
The
disruption
internal
disulfide
bonds
induces
unfolding
relaxation
protein,
leading
formation
an
amorphous
sol
through
chain
entanglement
as
primary
cross‐linking
points.
These
relaxed
further
aggregate
conformational
transition
initiate
rich
β‐sheet
structures
at
high
temperature,
resulting
gel
with
nanocrystals
serving
secondary
This
facilitates
precise
extrusion‐based
proteinaceous
hierarchically
structure.
biomedical
potential
this
3D‐printed
scaffold
preliminarily
validated
its
biomineralization
capability
following
application
bone
tissue
regeneration
using
rat
skull
defect
models.
demonstrates
facile
approach
structural
proteins
vitro
holds
great
field
protein‐based
scaffolds.
Particle & Particle Systems Characterization,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Janus
particles
that
have
regions
with
different
properties
(e.g.,
a
metal
and
polymer)
are
of
great
interest
for
extensive
technological
aspects
such
as
material
environmental
sciences,
surface
functional
chemistry,
drug
delivery,
biomedicals,
micro/nanomotors.
Numerous
techniques,
including
masking,
phase
separation,
self‐assembly,
been
presented
in
particle
fabrication.
Nonetheless,
method
precise
fabrication
is
challenging
necessary
to
control
the
accurately.
Here,
truncated‐cone
elongated
microparticles
one
epoxy‐based
negative
photoresist
(SU‐8)
deposited
gold
fabricated.
The
SU‐8
produced
by
micropatterning
height
width
design
aspect
ratios
1,
2,
5,
10
using
proton
beam
writing.
Gold
coating
on
subsequently
performed
magnetron
sputtering
technique.
Experimental
results
showed
ratio
had
exceed
2
side
surfaces.
These
can
be
uniform
sizes,
shapes,
thickness.
This
fabricating
well‐defined
adapted
many
applications,
particularly
metal‐polymer
microplastic
research.
The
study
analyzed
the
thermodynamic
parameters
of
Gibbs
free
energy,
enthalpy,
and
entropy
using
B3LYP
function
with
basis
set
6
–
311G(d,p)
density
functional
theory
in
Gaussian
16
software
program.
results
showed
that
energy
oxygen
is
spontaneous,
which
facilitating
docking
process
deoxyhemoglobin.
change
oxyhemoglobin
(0.566
eV)
this
value
used
as
a
standard
to
compare
all
other
results.
deoxyhemoglobin
greater
than
both
energies
heroin
nano
cinnamon,
values
are
positive,
indicating
compounds
release
heat.
total
more
stable
amount
oxygen,
binding
unstable
for
substances.
also
found
cinnamon
do
not
directly
affect
deoxyhemoglobin,
but
rather
it
gradually
due
non-spontaneous
reactions.
Nano
works
well
treatment
get
rid
negative
effects
on
body.
