Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This feature article comprehensively summarizes the research progress related to strategy of singlet oxygen storage and its controlled release in photodynamic therapy dark or hypoxic tumors.
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 17, 2024
Abstract The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact TRIM-targeted antibacteria on tumor inhibition and immune regulation microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating with antitumor treatment, addressing aggravated immunosuppression overgrowth induced TRIM using breast prostate cancer models. Combining Ag + release a Fenton-like reaction photothermal conversion, simultaneous bacteria killing multimodal therapy are enabled single agent. Free immune-stimulating drugs, agent restores surveillance activates immunological responses. Secondary inoculation distal analysis confirm lasting memory systemic A >700 days is achieved. This work unravels crucial unlocks an unconventional route for TME complete cure cancer.
Язык: Английский
Процитировано
12
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application tumors. To overcome these limitations, a self‐sustained organelle‐mimicking nanoreactor is developed here with programmable DNA switches that enables bio‐chem‐photocatalytic cascade‐driven starvation‐photodynamic synergistic against tumor metastasis. Emulating compartmentalization positional assembly strategies found living cells, this nano‐organelle reactor allows quantitative co‐compartmentalization multiple functional modules designed self‐illuminating chemiexcited PDT system. Within space‐confined nanoreactor, biofuel glucose converted hydrogen peroxide (H 2 O ) which enhances luminol‐based chemiluminescence (CL), consequently driving generation photochemical singlet ( 1 via resonance energy transfer. Meanwhile, hemoglobin functions as synchronized supplier both oxidation PDT, while also exhibiting peroxidase‐like activity produce hydroxyl radicals (·OH). Crucially, keeps switching off normal tissues, on‐demand activation tumors through toehold‐mediated strand displacement. These findings demonstrate self‐sufficient precise striking tumors, promising paradigm managing highly metastatic cancers.
Язык: Английский
Процитировано
2
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 6, 2025
Clinical cancer treatment modalities include radiation as one of the first-line therapies used for treating almost two-thirds patients. Combinational therapy is becoming extremely popular, with multiple and their pharmacological effects expected to provide a synergistic outcome. The nanotechnology-based combinational therapeutic approach emerging more effective strategy, its advantages simultaneous loading drugs, on-demand drug delivery controlled by external or internal stimulus, targeting particular site, potential combine physical (like radiation, thermal therapies, etc.) chemical interventions chemotherapy, immunotherapy, etc.). We report combination radiotherapy chemotherapy mediated multifunctional lipo-polymeric hybrid nanosystem coated gold, demonstrating three different functionalities using single nanosystem: a) radio sensitization, b) radiation-triggered c) application an X-ray/CT contrast agent. nanoparticles, synthesized modified hydrogel isolation method, were loaded natural plant-derived anti-cancer agent "Caflanone." These nanoparticles further subjected in-situ reduction surface coating which provided enhanced radiosensitivity, triggered imaging. This leverages biocompatibility system precise spatiotemporal controllability release, cytotoxicity A significant efficacy in vitro against breast (p = 0.0002), pancreatic < 0.0001), glioblastoma 0.0001) was demonstrated approach. has been shown vivo tumor-bearing mice safety profile histopathology evaluated healthy showed no adverse effects. increase 0.01) survival treated also demonstrated. engineered release at tumor triggering action encapsulated chemotherapeutic agents while providing image guidance.
Язык: Английский
Процитировано
1
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
The wash-free method represents a promising strategy for enhancing the detection efficiency of automated chemiluminescent (CL) immunoassay analyzers. Herein, novel separation-free and was developed first time based on distance-driven CL technique. In immunoassay, well-designed Au–Co metal nanoclusters (NCs) exhibited excellent peroxidase-like activity good stability, allowing efficient catalysis luminol or its analogue (ABEI)-H2O2 system even at low concentrations. Furthermore, large specific surface area NCs facilitated accommodation greater number antibodies, thereby capture antigens achieving dual amplification signal. technique relied formation sandwich-type immunocomplexes. Upon generation hydroxyl radicals superoxide anion through catalytic decomposition H2O2 by NCs, ABEI within immunocomplexes could efficiently react with these radicals, leading to significant enhancement in signals. C-reactive protein (CRP) chosen as model analyte evaluate practicability proposed immunoassay. Notably, presented high sensitivity, selectivity, reproducibility, successfully determining CRP serum samples recoveries 96.55–106.29%. Accordingly, advantage separation-free, wash-free, reliable characteristics drastically simplify operation steps enhance efficiency, which would make advances revolution traditional
Язык: Английский
Процитировано
1
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17759 - 17767
Опубликована: Июль 24, 2024
Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) showed great potential for bioimaging due to their integration of non-in situ excitation and deep tissue penetration. However, PLNPs are often introduced with Cr3+ ions as the NIR emission centers. Herein, we report Cr-free Bi2Ga3.985O9:1.5% Fe3+ (BGF), BGF under 310 nm exhibited afterglow at 794 in first biological imaging window (650–950 nm), duration 3 h. was grafted hydroxyl groups then polydopamine (PDA) indocyanine green (ICG) through π–π stacking hydrophobic interactions, PLNP–PDA–ICG composite. Bi composite, a heavy atom element, exhibits computed tomography (CT) contrast capacity, while PDA is photothermal agent, ICG excited produce reactive oxide species photodynamic therapy. The afterglow/CT dual-modality imaging-guided photothermal/photodynamic combination therapy validated vitro/vivo therapeutic applications. This work provides PLNP composite drug-free theranostics low toxicity.
Язык: Английский
Процитировано
8
ACS Nano, Год журнала: 2024, Номер 18(43), С. 29930 - 29941
Опубликована: Окт. 18, 2024
Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity selectively eradicate diseased tissues while minimizing damage normal tissue. Nevertheless, efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, dearth suitable photosensitizers and pronounced imaging-treatment disparity pose challenges. Additionally, implementation via optical fiber implantation carries infection risks necessitates minimally invasive surgery, contradicting PDT's noninvasive advantage. In this study, we introduce brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) develop visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate therapeutic inaccessible conventional PDT, demonstrating significant suppression inflammatory diffusion vivo using AIEgen TBPPM loaded within VLP, which exhibits transmittance 86% thickness 3 mm. This innovative effectively overcomes substantial limitations PDT settings holds promise for advancing phototherapy.
Язык: Английский
Процитировано
6
Journal of Material Science and Technology, Год журнала: 2024, Номер 213, С. 196 - 212
Опубликована: Июль 6, 2024
Язык: Английский
Процитировано
5
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113720 - 113720
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110290 - 110290
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
3
Nano Letters, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Persistent luminescent nanoparticles (PLNPs) are promising for many bioapplications due to their unique afterglow luminescence following the stoppage of light excitation. However, PLNPs prone surface quenching that results in weak luminescence. Although some efforts have been made reduce through designing homogeneous core-shell PLNPs, enhancement was insignificant. We hypothesize independent absorption and emission shell caused less energy reach activator ions core. Hence, a heterogeneous PLNP where has higher band gap than core would shell. In this work, ZnGa
Язык: Английский
Процитировано
3