Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
feature
article
comprehensively
summarizes
the
research
progress
related
to
strategy
of
singlet
oxygen
storage
and
its
controlled
release
in
photodynamic
therapy
dark
or
hypoxic
tumors.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Abstract
The
development
of
phototherapeutics
with
high
photothermal
conversion
efficiency
(PCE)
and
strong
ability
to
generate
reactive
oxygen
species
under
single
near-infrared
(NIR)
laser
irradiation
for
immuno-phototherapy
applications
remains
a
significant
challenge.
Herein,
we
optimally
selected
the
molecule
IT-4F
an
acceptor-donor-acceptor
(A-D-A)
structure
prepare
water-dispersible
nanoparticles
(NPs)
by
assembly
DSPE-PEG-NH2.
Such
NPs
have
NIR
absorption
fluorescence
peaks
at
728
817
nm,
respectively.
They
can
singlet
(1O2)
superoxide
anion
(O2-·)
irradiation,
1O2
generation
quantum
yield
31.5%.
also
effectively
convert
photon-energy
into
heat
PCE
42.8%.
outstanding
properties
enable
them
be
used
in
imaging
guided
therapy
(PTT),
photodynamic
(PDT).
Moreover,
PDT
PTT
triggered
immunogenic
cell
death
PANoptosis
tumor
cells,
which
not
only
inhibited
growth
metastasis
mice
model,
but
induced
robust
immune
response,
evidenced
increased
infiltration
CD8+
T
CD4+
dendritic
decreased
presence
immunosuppressive
cells
such
as
myeloid-derived
suppressor
regulatory
cells.
efficacy
organoid
human
breast
cancer
was
verified.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
advent
of
autonomous
nanomotors
presents
exciting
opportunities
for
nanodrug
delivery.
However,
significant
potential
remains
enhancing
the
asymmetry
and
advancing
development
second
near-infrared
(NIR-II)
light-propelled
capable
operating
within
deep
tissues.
Herein,
we
developed
a
dual-ligand
assisted
anisotropic
assembly
strategy
that
enables
precise
regulation
interfacial
energy
between
selenium
(Se)
nanoparticle
periodic
mesoporous
organosilica
(PMO).
This
facilitates
controllable
growth
PMO
on
Se
nanoparticle,
leading
to
formation
Se&PMO
Janus
nanohybrids.
exposure
ratio
subunit
nanohybrids
can
be
finely
tuned
from
0%
75%.
Leveraging
transformability
subunit,
variety
functional
MxSe&PMO
nanocomposites
(MxSe
denotes
metal
selenide)
were
further
derived.
As
proof
concept,
CuSe&PMO
nanohybrids,
with
NIR-II
photothermal
properties,
employed
as
light-driven
nanomotors.
By
precisely
controlling
CuSe
nanostructure,
these
achieved
optimal
self-propulsion,
thus
cellular
uptake
promoting
tumor
penetration.
Furthermore,
high
loading
capacity
hydrophobic
framework
enabled
incorporation
disulfiram,
thereby
significantly
boosting
efficacy
synergistic
active-motion
therapy.
Gene
therapy
has
evolved
into
a
clinically
viable
strategy,
with
several
approved
products
demonstrating
its
therapeutic
potential
for
genetic
disorders,
cancer,
and
infectious
diseases,
it
ample
applications
in
regenerative
medicine.
Its
success
depends
on
the
ability
to
efficiently
specifically
deliver
nucleic
acids
(NAs)
target
cells.
Although
viral
or
chemical
carriers
have
been
used
pioneering
applications,
safety
concerns,
variable
delivery
efficiencies
prompted
search
alternative
vehicles.
Light-mediated
strategies
gained
particular
interest
due
their
biocompatibility
improve
intracellular
efficiency.
In
this
review,
we
focus
recent
advancements
development
of
light-triggered
NA
discuss
how
they
can
be
designed
overcome
specific
barriers.
Additionally,
notable
highlight
challenges
opportunities
translating
technology
clinical
setting.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Abstract
The
rapidly
advancing
field
of
theranostics
aims
to
integrate
therapeutic
and
diagnostic
functionalities
into
a
single
platform
for
precision
medicine,
enabling
the
simultaneous
treatment
monitoring
diseases.
Photo‐energy
conversion‐based
nanomaterials
have
emerged
as
versatile
that
utilizes
unique
properties
light
activate
with
high
spatial
temporal
precision.
This
review
provides
comprehensive
overview
recent
developments
in
photo‐energy
conversion
using
nanomaterials,
highlighting
their
applications
disease
theranostics.
discussion
begins
by
exploring
fundamental
principles
including
types
materials
used
various
light‐triggered
mechanisms,
such
photoluminescence,
photothermal,
photoelectric,
photoacoustic,
photo‐triggered
SERS,
photodynamic
processes.
Following
this,
delves
broad
spectrum
emphasizing
role
diagnosis
major
diseases,
cancer,
neurodegenerative
disorders,
retinal
degeneration,
osteoarthritis.
Finally,
challenges
opportunities
technologies
are
discussed,
aiming
advance
personalized
medicine.
Abstract
Nanomaterials
including
metal
or
oxide
nanoparticles,
carbonous
nanomaterial
(e.g.,
carbon
dots)
metal–organic
framework
nanoparticles
provide
porous,
catalytically
active
surfaces
and
functional
interfaces
for
binding
of
ions
molecular
agents.
By
the
conjugation
nucleic
acids
to
hybrid
nanostructures
revealing
emerging
multimodal
catalytic/photocatalytic
activities,
high
loading
capacities,
effective
targeted
cell
permeation
efficacies
are
formed.
The
review
article
exemplifies
application
acid‐modified
conjugates
therapeutic
treatment
cancer
cells.
Stimuli‐responsive
reconfiguration
acid
strands
specific
recognition
catalytic
function
oligonucleotides
associated
with
catalytic,
photocatalytic
yield
composites
demonstrating
cooperative
synergistic
properties
medical
applications.
chemodynamic,
photodynamic,
photothermal
chemotherapeutic
cells
by
oligonucleotide/nanoparticle
is
addressed.
In
addition,
gene
therapy
discussed.