Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4F an acceptor-donor-acceptor (A-D-A) structure prepare water-dispersible nanoparticles (NPs) by assembly DSPE-PEG-NH₂. Such NPs have NIR absorption fluorescence peaks at 728 817 nm, respectively. They can singlet (¹O₂) superoxide anion (O₂^-·) irradiation, ¹O₂ generation quantum yield 31.5%. also effectively convert photon-energy into heat PCE 42.8%. outstanding properties enable them be used in imaging guided therapy (PTT), photodynamic (PDT). Moreover, PDT PTT triggered immunogenic cell death PANoptosis tumor cells, which not only inhibited growth metastasis mice model, but induced robust immune response, evidenced increased infiltration CD8⁺ T CD4⁺ dendritic decreased presence immunosuppressive cells such as myeloid-derived suppressor regulatory cells. efficacy organoid human breast cancer was verified.

Язык: Английский

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Dual-Ligand Assisted Anisotropic Assembly for the Construction of NIR-II Light-Propelled Mesoporous Nanomotors

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The advent of autonomous nanomotors presents exciting opportunities for nanodrug delivery. However, significant potential remains enhancing the asymmetry and advancing development second near-infrared (NIR-II) light-propelled capable operating within deep tissues. Herein, we developed a dual-ligand assisted anisotropic assembly strategy that enables precise regulation interfacial energy between selenium (Se) nanoparticle periodic mesoporous organosilica (PMO). This facilitates controllable growth PMO on Se nanoparticle, leading to formation Se&PMO Janus nanohybrids. exposure ratio subunit nanohybrids can be finely tuned from 0% 75%. Leveraging transformability subunit, variety functional MxSe&PMO nanocomposites (MxSe denotes metal selenide) were further derived. As proof concept, CuSe&PMO nanohybrids, with NIR-II photothermal properties, employed as light-driven nanomotors. By precisely controlling CuSe nanostructure, these achieved optimal self-propulsion, thus cellular uptake promoting tumor penetration. Furthermore, high loading capacity hydrophobic framework enabled incorporation disulfiram, thereby significantly boosting efficacy synergistic active-motion therapy.

Язык: Английский

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Beyond chemotherapy: Spatiotemporal activation of metal complexes for deep-tissues precision medicine

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216664 - 216664

Опубликована: Март 30, 2025

Язык: Английский

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The synthesis, photophysical and biological properties of 5,10,15,20-tetra(4-substituted phenyl)tetrabenzoporphyrin derivatives

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117612 - 117612

Опубликована: Апрель 1, 2025

Язык: Английский

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Regulated cell death mechanisms in mitochondria-targeted phototherapy

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113720 - 113720

Опубликована: Апрель 1, 2025

Язык: Английский

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Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 23, 2025

Язык: Английский

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Targeted Drug Delivery with Photoluminescent Emitters: Applications in Diagnostic

Engineering materials, Год журнала: 2025, Номер unknown, С. 75 - 119

Опубликована: Янв. 1, 2025

Язык: Английский

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Light-triggered nanocarriers for nucleic acid delivery

Drug Delivery, Год журнала: 2025, Номер 32(1)

Опубликована: Май 14, 2025

Gene therapy has evolved into a clinically viable strategy, with several approved products demonstrating its therapeutic potential for genetic disorders, cancer, and infectious diseases, it ample applications in regenerative medicine. Its success depends on the ability to efficiently specifically deliver nucleic acids (NAs) target cells. Although viral or chemical carriers have been used pioneering applications, safety concerns, variable delivery efficiencies prompted search alternative vehicles. Light-mediated strategies gained particular interest due their biocompatibility improve intracellular efficiency. In this review, we focus recent advancements development of light-triggered NA discuss how they can be designed overcome specific barriers. Additionally, notable highlight challenges opportunities translating technology clinical setting.

Язык: Английский

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Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Abstract The rapidly advancing field of theranostics aims to integrate therapeutic and diagnostic functionalities into a single platform for precision medicine, enabling the simultaneous treatment monitoring diseases. Photo‐energy conversion‐based nanomaterials have emerged as versatile that utilizes unique properties light activate with high spatial temporal precision. This review provides comprehensive overview recent developments in photo‐energy conversion using nanomaterials, highlighting their applications disease theranostics. discussion begins by exploring fundamental principles including types materials used various light‐triggered mechanisms, such photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered SERS, photodynamic processes. Following this, delves broad spectrum emphasizing role diagnosis major diseases, cancer, neurodegenerative disorders, retinal degeneration, osteoarthritis. Finally, challenges opportunities technologies are discussed, aiming advance personalized medicine.

Язык: Английский

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Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Abstract Nanomaterials including metal or oxide nanoparticles, carbonous nanomaterial (e.g., carbon dots) metal–organic framework nanoparticles provide porous, catalytically active surfaces and functional interfaces for binding of ions molecular agents. By the conjugation nucleic acids to hybrid nanostructures revealing emerging multimodal catalytic/photocatalytic activities, high loading capacities, effective targeted cell permeation efficacies are formed. The review article exemplifies application acid‐modified conjugates therapeutic treatment cancer cells. Stimuli‐responsive reconfiguration acid strands specific recognition catalytic function oligonucleotides associated with catalytic, photocatalytic yield composites demonstrating cooperative synergistic properties medical applications. chemodynamic, photodynamic, photothermal chemotherapeutic cells by oligonucleotide/nanoparticle is addressed. In addition, gene therapy discussed.

Язык: Английский

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