Transition-metal-free phosphorylation of polyfluoroarenes with P(O)H compounds
Bingqian Sun,
Yongqiang Liang,
Meng-Ting Xiang
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
23(10), С. 2358 - 2361
Опубликована: Янв. 1, 2025
Herein,
a
base-promoted
C-P(O)
bond
formation
method
has
been
developed
for
the
phosphorylation
of
polyfluoroarenes
through
selective
C-F
cleavage.
The
high
selectivity
and
mild,
transition-metal-free
conditions
this
underscore
its
potential
sustainable
synthesis
applications.
This
expands
scope
polyfluoroarene
functionalization,
providing
valuable
tool
incorporating
phosphorus
motifs
in
complex
aromatic
frameworks.
Язык: Английский
Visible Light-Promoted Defluorinative Alkylation of Trifluoromethyl Ketones with α-Aminoalkyl Boron Species
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
In
this
study,
we
developed
a
photoredox-catalyzed
defluorinative
cross-coupling
method
for
trifluoroketones
and
alkyl
boronic
acids.
The
reaction
afforded
series
of
novel
α,α-difluoroketone
derivatives,
in
vitro
fungicidal
activity
revealed
that
some
these
compounds
exhibited
moderate
to
excellent
against
Rhizoctonia
solani
Botrytis
cinerea.
particular,
compound
3d
showed
an
EC50
value
4.27
μg/mL
B.
cinerea
can
be
used
as
lead
further
optimization.
Язык: Английский
Controlled synthesis of polymers in the light of green chemistry
Russian Chemical Reviews,
Год журнала:
2025,
Номер
94(4), С. RCR5164 - RCR5164
Опубликована: Апрель 1, 2025
The
discovery
of
reversible
deactivation
radical
polymerization
(RDRP),
or
controlled
(CRP)
has
revolutionized
the
chemistry
synthetic
polymers.
This
strategy
opened
up
way
to
polymer
materials
with
architecture,
composition,
and
functions.
Currently,
owing
use
novel
approaches
related
chain
deactivation,
gone
beyond
synthesis.
It
can
be
used
obtain
not
only
macromolecular
organic
compounds,
but
also
organic-inorganic
hybrid
materials,
bioconjugates,
promising
polymers
for
electronics,
energy
production,
medicine,
other
high-tech
fields.
is
exceptionally
important
that
some
CRP
methods
have
a
clear-cut
environmental
component,
since
they
are
focused
on
compliance
most
principles
green
development
nature-like
processes
in
targeted
synthesis
well-defined
specified
set
properties
characteristics.
review
considers
particular
examples
analyzes
possible
prospects
practical
application
environmentally
benign
functional
A
comparative
analysis
performed
classical
living
wide
range
monomers
(reversible
inhibition,
addition
fragmentation
transfer,
atom
transfer
involving
transition
metal
complexes),
concept
photoredox
catalysis,
methodology
as
applied
gives
above
aspects,
including
procedural
details
photoinitiation
their
relationship
key
principles.
In
our
opinion,
this
will
interest
specialists
field
chemistry,
chemists
scientists.
<br>
bibliography
includes
242
references.
Язык: Английский
Polarity-Driven Thiyl Radical-Catalyzed Aerobic Debenzylation of Ethers and Amines
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(20), С. 15062 - 15067
Опубликована: Окт. 9, 2024
We
report
the
use
of
a
strongly
electrophilic
thiyl
radical
derived
from
commercially
available
pentafluorothiophenol
as
demonstration
highly
chemoselective
H
atom
abstraction
electron-rich
and
relatively
weak
benzylic
C–H
bonds
adjacent
to
O
N
atoms.
This
approach
enables
selective
oxidative
removal
benzyl
p-methoxybenzyl
groups
amines
ethers
under
ambient
aerobic
conditions.
Язык: Английский
Current trends in organic chemistry: contribution of the N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
Russian Chemical Bulletin,
Год журнала:
2024,
Номер
73(9), С. 2423 - 2532
Опубликована: Сен. 1, 2024
Язык: Английский
Photocatalytic Functionalization of Alkenes Enabled by Polyfluoroaryl Migration
ChemPhotoChem,
Год журнала:
2024,
Номер
8(11)
Опубликована: Июнь 19, 2024
Abstract
Visible
light‐mediated
photocatalytic
approach
for
the
radical
functionalization
of
alkenes
bearing
fluorinated
aryl
sulfide
fragment
is
described.
The
process
occurs
in
presence
organic
photocatalyst
using
sulfinates
as
sources
radicals.
key
step
reaction
intramolecular
1,4‐migration
polyfluoroaryl
group.
In
reaction,
three
new
bonds
are
formed
(two
C−C
and
one
C−S
bond).
decisive
role
fluorine
atoms
efficiency
was
confirmed
by
DFT
calculations.
Язык: Английский
Polyfluorinated benzoic acids as promising reagents for organic synthesis and medicinal chemistry
Russian Chemical Reviews,
Год журнала:
2024,
Номер
93(8), С. RCR5131 - RCR5131
Опубликована: Авг. 1, 2024
Polyfluoroaromatic
compounds
occupy
a
special
place
in
organic
synthesis
due
to
wide
range
of
their
chemical
transformations
and
unique
biological
properties.
The
introduction
the
carboxyl
function
into
polyfluoroarenes
allows
further
diversification
chemistry
these
compounds.
This
review
summarizes
data
on
polyfluorobenzoic
acids,
including
derivatives
polyfluorosalicylic
acids.
reactions
esterification,
amidation,
reduction,
decarboxylation,
metal-catalyzed
decarboxylative
cross-coupling,
C–H
functionalization,
reductive
defluorination,
nucleophilic
aromatic
substitution,
heterocyclization
complex
formation
are
considered.
Reactivity
features
polyfluorobenzoates
comparison
non-fluorinated
counterparts
highlighted.
potential
for
practical
applications
acid
derivatives,
primarily
as
biologically
active
compounds,
is
presented.
<br>
Bibliography
includes
300
references.
Язык: Английский
Photoinduced, Redox-Neutral Decyanative and Defluorinative Phosphination of (Hetero)Arenes
Organic Letters,
Год журнала:
2024,
Номер
26(38), С. 8154 - 8158
Опубликована: Сен. 16, 2024
Triarylphosphines
play
a
crucial
role
in
organic
synthesis
as
versatile
components
serving
ligands,
catalysts,
and
reactants.
This
study
introduces
metal-free,
visible-light-induced
method
for
the
cross-coupling
of
cyanopyridines
or
polyfluoroarenes
with
diarylphosphines.
approach
facilitates
formation
C(sp
Язык: Английский
The Ground State of Multispin Systems Based on Verdazyl and Nitrene Radicals: An EPR and Quantum-Chemical Study
The Journal of Physical Chemistry A,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
In
this
study,
low-temperature
EPR
spectroscopy
and
quantum-chemical
techniques
were
employed
to
investigate
multispin
systems─1,5-diphenyl-3-(3-nitrenophenyl)-6-oxoverdazyl
1,5-diphenyl-3-(4-nitrenophenyl)-6-oxoverdazyl─that
contain
a
nitrene
center
at
either
meta-
or
para-position,
respectively.
Ground
states
magnetic
zero-field
splitting
(ZFS)
parameters
of
these
systems
determined
by
experimental
computational
methods.
The
results
indicated
that
the
high-spin
quartet
state
is
ground
state,
quartet-doublet
energy
gap
close
10
kcal/mol
for
para-position
group,
with
ZFS
D
=
0.292
cm-1
E/D
0.002
cm-1.
contrast,
meta-position,
low-spin
doublet
favored
an
1
kcal/mol.
observed
difference
in
could
be
qualitatively
explained
analysis
spin
density
distribution
delocalization
unpaired
π-electron
center.
Overall,
study
provides
valuable
insights
into
electronic
structures
such
systems.
Язык: Английский