ACS Macro Letters,
Год журнала:
2024,
Номер
13(7), С. 834 - 840
Опубликована: Июнь 24, 2024
Supramolecular
coordination
complexes
(SCCs)
are
popular
for
their
structural
diversity
and
functional
adaptability,
which
make
them
suitable
a
wide
range
of
applications.
Photophysical
mechanical
performance
SCCs
the
most
attractive
characteristics,
yet
ionically
conductive
behavior
potential
in
electrical
sensing
have
been
rarely
investigated.
This
study
reports
well-designed
SCC
that
integrates
orthogonal
metal
host–guest
interactions
to
achieve
sensitive
thermal
sensing.
Owing
thermodynamic
nature
interaction,
encounters
thermally
induced
disassembly,
leading
significantly
enhanced
ion
mobility
thus
allowing
precise
detection
minor
temperature
variation.
The
SCC-based
thermometer
is
then
fabricated
with
assistance
3D
printing
demonstrates
good
accuracy
reliability
monitoring
human
skin
real-time
changes
mouse
during
whole
anesthesia
recovery
process.
Our
findings
provide
an
innovative
strategy
developing
thermometers
expand
current
application
scope
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Near-infrared
(NIR)
light-mediated
photothermal
and
photodynamic
therapies
are
promising
for
nonsurgical
treatment
of
skin
diseases.
However,
the
skin's
inherent
light
absorption,
especially
from
melanin
in
epidermis,
attenuates
NIR
energy
penetration,
limiting
efficacy
potentially
causing
off-target
tissue
damage.
In
this
context,
we
developed
subcutaneous
response-enhanced
microneedles
(SLE
MNs)
that
allow
basal
layer-localized
seeding
therapeutics
leverage
physical
channels
to
efficiently
transmit
transdermally,
facilitating
situ
scattered
activation
enhanced
therapy
outcomes.
Such
ultraoptical
SLE
MNs
facilitated
achieving
up
80%
initial
power
at
500
μm
subcutaneously,
representing
an
approximate
160%
increase
compared
control
groups.
Additionally,
conceptualized
a
two-segmented
MN
structure
integrating
light-guiding
with
photoresponsive
enable
precise
basal-layer
treatment,
effectively
mitigating
local
hyperenergy
on
surface
attenuation
within
tissues.
This
optical
patch
offers
transformative
platform
transdermal
significant
clinical
potential.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Highly
emissive
metallacages
that
generate
reactive
oxygen
species
(ROS)
are
important
to
synergistic
cancer
therapy,
but
it
is
still
challenging
balance
the
emission
and
phototheranostic
properties.
Herein,
a
metallacage
of
DTPABT-Mc
prepared.
It
observed
in
near-infrared
region
from
600
1000
nm
with
high
photoluminescence
quantum
yield
value
7.92%
solids
recorded
for
DTPABT-Mc.
In
addition,
ability
produce
both
type
I
II
ROS
under
light
irradiation
also
observed,
leading
potential
application
photodynamic
therapy
(PDT)
chemotherapy.
After
that,
4T1@DTPABT-Mc-NPs,
covering
nanoparticles
4T1
cell
membranes,
prepared
enhance
their
tumor-targeting
ability.
This
finally
results
effective
therapeutic
performance
vivo,
effectively
inhibiting
tumor
growth.
These
suggest
DTPABT-Mc-NPs
exhibit
excellent
effects
by
combining
PDT
chemotherapy,
providing
new
ideas
design
agents
diagnosis
future.
