Multifunctional Ultra‐Bright Plasmonic Gold@Fluorescence Nanoprobe for Biomedical Applications

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

ABSTRACT Metal‐enhanced fluorescence (MEF) represents a captivating phenomenon that transpires when fluorophores are situated in close vicinity to the surface of metallic nanostructures, leading nuanced augmentation their fluorescent characteristics. Given its efficacy enhancing excitation rates, quantum yield, and photostability, MEF has firmly established itself as highly valuable tool for augmenting biosensor sensitivity, bioimaging clarity, intensifying therapeutic responses. Notably, plasmonic gold inherently advantageous MEF, have been widely utilized signal amplification, labeling, theranostics. In this endeavor, we undertake comprehensive examination MEF‐enabled meticulously analyzing fundamental enhancement mechanisms, crucial influencing factors, diverse modes enhancement. Furthermore, spotlight exemplary applications these nanostructures biosensing, bioimaging, theranostics, underscoring revolutionary potential. Ultimately, offer glimpse into future prospects improvement challenges beset gold‐based MEF. Our attention is steadfastly directed toward essential scientific questions technical hurdles remain be surmounted, inviting readers partake an exciting exploration dynamic promising field.

Язык: Английский

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Self-Assembly of Nanogold Triplets on Trimeric Viral Proteins for Infectious Disease Diagnosis

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Timely and accurate diagnostics for infectious diseases are essential in preventing their worldwide spread. Though rapid diagnostic tests favored speed, cost-effectiveness, ease of use, most compromise sensitivity, which risks false-negative results. Here, we present the self-assembly nanogold triplets on trimeric viral surface proteins a sensitive colorimetric assay to identify viruses. Gold were self-assembled using ultrasmall gold nanoparticles. We observed significant wavelength shift 70 nm, enabling straightforward naked-eye detection through that act as catalysts producing nanoplasmonic established limit 3 × 105 copies/ml an effective detecting SARS-CoV-2. The provides reliable approach

Язык: Английский

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Gold Nanoparticles-Based Colorimetric Immunoassay of Carcinoembryonic Antigen with Metal–Organic Framework to Load Quinones for Catalytic Oxidation of Cysteine

Sensors, Год журнала: 2024, Номер 24(20), С. 6701 - 6701

Опубликована: Окт. 18, 2024

This work reported gold nanoparticles (AuNPs)-based colorimetric immunoassay with the Cu-based metal–organic framework (MOF) to load pyrroloquinoline quinone (PQQ) for catalytic oxidation of cysteine. In this method, both Cu2+ and PQQ in MOF could promote inducer cysteine by redox cycling, thus limiting cysteine-induced aggregation AuNPs achieving dual signal amplification. Specifically, recombinant carcinoembryonic antigen (CEA) targets were anchored on through metal coordination interactions between hexahistidine (His6) tag CEA unsaturated sites MOF. The CEA/PQQ-loaded be captured antibody-coated ELISA plate catalyze However, once target samples bound antibody immobilized surface, attachment would limited. Cysteine remaining solution trigger cause a color change from red blue. concentration was positively related AuNPs. signal-on competitive plasmonic exhibited low detection limit linear range 0.01–1 ng/mL. Note that most proteins commercial kits are His6 N- or C-terminal, so provide sensitive platform biomarkers.

Язык: Английский

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Plasmon-enhanced fluorescence sensor based on Au nanocages for sensitive detection of norepinephrine

Analytica Chimica Acta, Год журнала: 2025, Номер unknown, С. 343995 - 343995

Опубликована: Апрель 1, 2025

Язык: Английский

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Nonlocal optical field effects in metal nanoplasmonics influenced by dielectric environments

AIP Advances, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

Metal nanoplasmonics has emerged as a transformative platform for sub-diffraction-limited light manipulation, owing to its unique capability confine and enhance optical fields at the nanoscale. While significant progress been made in understanding plasmon-enhanced phenomena over past two decades, theoretical investigations into how nanoscale dielectric environments influence properties of metallic plasmonic nanostructures remain limited. In this work, we employ quantum hydrodynamic model develop unified approach analyzing nonlocal field effects metal–dielectric nanowire systems. Our findings demonstrate that permittivity exerts long-range on resonance frequency nanostructures, with higher constants inducing redshift plasmon frequency. Furthermore, inter-wire spacing between nanowires critically affects distribution enhancement. Notably, decreasing dielectric–metal proximity does not universally light-field amplification. A primary factor contributing observation is interfacial screening alters mode’s effective wavelength. These results promise establish foundational design principles advanced nanophotonic devices.

Язык: Английский

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Integrative plasmonics: optical multi-effects and acousto-electric-thermal fusion for biosensing, energy conversion, and photonic circuits

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review traces the evolution from classical to integrative plasmonics, detailing optical multi-effects of plasmons and their acousto-optic-electric-thermal fusion. It discusses key integration mechanisms, applications, future prospects.

Язык: Английский

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Self-Assembly versus Coassembly: An Amphiphilic NIR-II Aggregation-Induced Emission Luminogen for Phototheranostics of Orthotopic Glioblastoma

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Glioblastoma (GBM) is the most lethal form of malignant brain tumor, known for its high infiltration, aggressiveness, and poor prognosis. Second near-infrared (NIR-II, 1000-1700 nm) phototheranostic agents bring intriguing opportunities GBM management owing to their noninvasive nature, controllability, deeper tissue penetration. Herein, an amphiphilic NIR-II luminogen (PEG-TD) with aggregation-induced emission (AIE) characteristics, along hydrophobic counterpart (C6-TD), was meticulously synthesized. Specifically, PEG-TD nanoparticles (NPs), formed through straightforward self-assembly, exhibited superior stability, simplicity, robust reactive oxygen species production efficiency, excellent photothermal conversion compared C6-TD NPs, which were fabricated via coassembly DSPE-mPEG, primarily attributed distinct molecular arrangements within forming aggregates. The inherent advantages NPs led significant therapeutic efficacy against GL261 cells under 808 nm laser irradiation. Eventually, fluorescence/photothermal duplex imaging-guided combined photodynamic/photothermal therapy successfully performed in orthotopic glioblastoma mouse model minimal adverse effects.

Язык: Английский

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Nanoplasmonic biosensors for detecting viruses and combating viral infections

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Июнь 2, 2025

Язык: Английский

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