Cited by Mitochondria-targeted ruthenium complexes can be generated in vitro and in living cells to target triple-negative breast cancer cells by autophagy inhibition

Photoactivation of cGAS-STING Pathway and Pyroptosis by Endoplasmic Reticulum-Targeting Ruthenium(II) Complex for Cancer Immunotherapy DOI

Bin-Fa Liang,

Shan Jiang,

Yun-Shi Zhi

и другие.

Inorganic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A cholic acid-modified ruthenium( ii ) (Ru1) photosensitizer was synthesized. Ru1 induced pyroptosis and sequentially engaged the downstream proteins p-TBK1 p-IRF3 within STING pathway, thus promoting elicitation of tumor immune responses.

Язык: Английский

Процитировано

Targeting oxygenases could be a viable anti-metastatic approach in cancer therapy DOI

Pengfei Shi, Jie Xu,

Hongjuan Cui

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143375 - 143375

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes DOI

Hui Wang,

Xuejing Fan,

Pei‐Pei Xie

и другие.

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 67(2), С. 1209 - 1224

Опубликована: Дек. 29, 2023

Ferrocidiphenols possessing appropriate substituents in the aliphatic chain have very promising anticancer properties, but a systematic approach to deciphering their diversified metabolic behavior has so far been lacking. Herein, we show that series of novel ferrocidiphenols bearing different hydroxyalkyl exhibit strong activity as revealed range vitro and vivo experiments. Moreover, they display oxidative transformation profiles distinct from those previous complexes, shown by use chemical enzymatic methods cellulo metabolism studies. In view this phenomenon, unprecedented chemo-evolutionary sequences connect all ferrocidiphenol-related intermediates analogues established. addition, comprehensive density functional theory (DFT) study performed decipher diversification these complexes demonstrate delicate modulation carbenium ions ferrocenyl moiety, via either α- or β-positional participation.

Язык: Английский

Процитировано

Mitochondria-targeted ruthenium complexes can be generated in vitro and in living cells to target triple-negative breast cancer cells by autophagy inhibition DOI

Guandong Zhang,

Mengmeng Wang, Yan Su

и другие.

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 256, С. 112574 - 112574

Опубликована: Апрель 23, 2024

Язык: Английский

Процитировано