Intracellular metal ion-based chemistry for programmed cell death
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Intracellular
metal
ions
play
essential
roles
in
multiple
physiological
processes,
including
catalytic
action,
diverse
cellular
intracellular
signaling,
and
electron
transfer.
It
is
crucial
to
maintain
ion
homeostasis
which
achieved
by
the
subtle
balance
of
storage
release
intracellularly
along
with
influx
efflux
at
interface
cell
membrane.
Dysregulation
has
been
identified
as
a
key
mechanism
triggering
programmed
death
(PCD).
Despite
importance
initiating
PCD,
molecular
mechanisms
within
these
processes
are
infrequently
discussed.
An
in-depth
understanding
review
role
PCD
may
better
uncover
novel
tools
for
cancer
diagnosis
therapy.
Specifically,
calcium
(Ca
Язык: Английский
Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and Alternatives
Inorganics,
Год журнала:
2024,
Номер
12(7), С. 190 - 190
Опубликована: Июль 12, 2024
Leishmaniasis
is
a
complex
disease
present
in
variety
of
manifestations
listed
by
the
World
Health
Organization
(WHO)
as
one
neglected
diseases
with
worse
prognosis
if
not
treated.
Medicinal
inorganic
chemistry
has
provided
drugs
based
on
metal–organic
complexes
synthesized
different
metal
centers
and
organic
ligands
to
fight
against
great
number
parasite
maladies
specifically
Leishmaniasis.
Taking
advantage
natural
properties
that
many
metals
for
biotechnological
purposes,
nanotechnology
offered,
recent
years,
new
approach
consisting
application
nanoparticles
treat
parasitic
diseases,
drug
vehicle
or
treatment
themselves.
The
aim
this
review
gather
most
widely
used
metallic
strategies
proposed
antileishmanial
agents.
Язык: Английский
Photoactivated Anticancer Activity of Cobalt(III) Complexes with Naturally Occurring Flavonoids Chrysin and Silibinin
ChemBioChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
Abstract
Photoactive
metal
complexes
of
bioessential
transition
ions
with
natural
chelators
are
gaining
interest
as
photocytotoxic
agents
for
cancer
photodynamic
therapy
(PDT).
We
report
six
new
cobalt(III)
a
mixed‐ligand
formulation
[Co(B)
2
(L)](ClO
4
)
(
Co1
–
Co6
),
where
B
represents
N,N‐donor
α
‐diimine
ligand,
namely,
phenanthroline
(phen;
,
Co2
dipyrido[3,2‐
d
:2’,3’‐
f
]quinoxaline
(dpq;
Co3
Co4
and
c
]phenazine
(dppz;
Co5
L
is
the
monoanionic
form
naturally
occurring
flavonoids
chrysin
(chry;
silibinin
(sili;
).
Complexes
displayed
d‐d
absorption
band
within
500–700
nm
exhibited
excellent
dark
photostability
in
solution.
Cytotoxicity
studies
indicated
significant
activity
against
cervical
(HeLa)
lung
(A549)
cells
under
visible
light
(400–700
nm)
irradiation
giving
low
micromolar
IC
50
values
(2.3–3.4
μM,
phototoxicity
index~15–30).
The
demonstrated
notably
toxicity
normal
HPL1D
epithelial
cells.
Flow
cytometry
assay
revealed
an
apoptotic
mode
cell
damage
triggered
by
when
irradiated.
ROS
generation
involvement
singlet
oxygen
species
death
mechanism
irradiated
light.
Overall,
coordinated
dipyridophenazine
flavonoid
ligands
potential
candidates
PDT
applications.
Язык: Английский
In Vitro and In Vivo Biological Evaluation of Novel 1,4‐Naphthoquinone Derivatives as Potential Anticancer Agents
ChemMedChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 13, 2024
Abstract
A
novel
library
of
naphthoquinone
derivatives
(
3–5
aa
)
was
synthesized
and
evaluated
for
their
anticancer
properties.
Specifically,
compounds
5
i,
l,
o,
q,
r,
s,
t
,
v
demonstrated
superior
cytotoxic
activity
against
the
cancer
cell
lines
that
were
studied.
All
studied
exhibited
a
higher
selectivity
index
(SI)
favourable
safety
profile
than
standard
drug
doxorubicin.
Notably,
compound
displayed
greater
effect
on
MCF‐7
cells
(IC
50
=1.2
μM,
0.9
μM
at
24
h
48
h,
respectively)
compared
to
doxorubicin
=2.4
2.1
respectively).
To
further
investigate
mechanism
effect,
additional
studies
conducted
with
in
cells.
The
are
including
morphological
changes,
AO/EB
(acridine
orange/ethidium
bromide)
double
staining,
apoptosis
analysis,
colony
assay,
SDS‐PAGE
Western
blotting,
cycle
detecting
reactive
oxygen
species
(ROS)
assay.
findings
showed
triggered
effects
through
initiation
arrest
G1/S
phase
necrosis.
In
vivo
ecotoxicity
indicated
had
lower
toxicity
towards
zebrafish
larvae
(LC
=50.15
μM)
an
insignificant
impact
cardiac
functions.
xenotransplantation
significant
reduction
tumour
volume
xenograft.
Approximately
95
%
xenografts
survived
after
10
days
treatment.
Finally,
computational
modelling
study
four
protein
receptors,
namely
ER,
EFGR,
BRCA1,
VEFGR2.
highlight
importance
aminonaphthoquinone
moiety,
amide
linkage,
propyl
thio
moiety
enhancing
drug‐likeness
features
docking
scores
(−9.1,
−7.1,
−8.9,
−10.9
kcal/mol)
(−7.2,
−6.1,
−6.9,
−7.3
VEGFR2
respectively.
Therefore,
notable
antitumor
suggest
these
molecular
frameworks
may
play
role
development
promising
agents
Язык: Английский