Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2915 - 2915

Опубликована: Март 2, 2024

In the era of a steadily increasing lifespan, neurodegenerative diseases among elderly present significant therapeutic and socio-economic challenge. A properly balanced diet microbiome diversity have been receiving attention as targets for interventions in neurodegeneration. Microbiota may affect cognitive function, neuronal survival death, gut dysbiosis was identified Parkinson’s disease (PD). Tryptophan (Trp), an essential amino acid, is degraded by microbiota hosts numerous compounds with immune- neuromodulating properties. This broad narrative review presents data supporting concept that microbiota, Trp-kynurenine (KYN) pathway aryl hydrocarbon receptors (AhRs) form triad involved PD. disturbed gut–brain axis allows bidirectional spread pro-inflammatory molecules α-synuclein, which contribute to development/progression disease. We suggest peripheral levels kynurenines AhR ligands are strongly linked Trp metabolism should be studied together composition microbiota. Such approach can clearly delineate sub-populations PD patients manifesting microbiota–Trp-KYN–brain triad, who would benefit from modifications metabolism. Analyses microbiome, Trp-KYN metabolites signaling shed light on mechanisms intestinal distress identify new diagnosis treatment early-stage Therapeutic based combination well-defined food regimen, probiotics seem potential require further experimental clinical research.

Язык: Английский

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Lactiplantibacillus plantarum DACNJS22 alleviates benzo(a)pyrene-induced neurobehavioral injury in mice: insights from gut microbiota and short-chain fatty acids

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105865 - 105865

Опубликована: Янв. 1, 2025

Язык: Английский

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Polygonatum sibiricum polysaccharide regulation of gut microbiota: A viable approach to alleviate cognitive impairment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134494 - 134494

Опубликована: Авг. 5, 2024

Язык: Английский

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Synergistic protective effects of probiotics Lactiplantibacillus plantarum S58 and prebiotics Qingke β-glucan on dextran sulfate sodium-induced cognitive deficits in colitis mice: A study of microbial-gut-brain axis modulation

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106266 - 106266

Опубликована: Март 1, 2025

Язык: Английский

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Beyond digestion: Exploring how the gut microbiota modulates human social behaviors

Neuroscience, Год журнала: 2024, Номер 565, С. 52 - 62

Опубликована: Ноя. 29, 2024

Язык: Английский

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