Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 3, 2025

Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows promise in UC animal models, but systematic review needed. A search was conducted across databases including PubMed, EBSCO, Web Science, Science Direct, up to March 2024, identifying randomized controlled trials (RCTs) examining baicalin's impact on models. Seventeen studies were selected through manual screening. Meta-analyses subgroup analyses utilized Rev Man 5.3 Stata 15.0 software assess symptom improvement. From 1304 citations, 17 analyzed. significantly modulated various biomarkers: HCS (SMD = -3.91), DAI (MD -2.75), spleen index -12.76), MDA -3.88), IL-6 -10.59), IL-1β -3.98), TNF-α -8.05), NF-κB -5.46), TLR4 -0.38), RORγ -0.89), MCP-1 -153.25), MPO -7.34), Caspase-9 -0.93), Caspase-3 -0.45), FasL -1.20)) enhanced BWC 0.06), CL 1.39), ZO-1 0.44), SOD 3.04), IL-10 mRNA 3.14), FOXP3 0.45) levels. Baicalin's actions may involve the PI3K/AKT, TLR4/NF-κB, IKK/IKB, Bcl-2/Bax, Th17/Treg, TLRs/MyD88 pathways. Optimal outcomes predicted at dosages 60–150 mg/kg over 10–14 weeks. demonstrates multifaceted potential UC, attributed its anti-inflammatory, antioxidant, anti-apoptotic, intestinal barrier repair properties. While higher doses longer appear beneficial, further research, particularly human clinical trials, necessary verify effectiveness safety people.

Язык: Английский

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Soluble Dietary Fiber from Fermentation of Tea Residues by Eurotium cristatum and the Effects on DSS-Induced Ulcerative Colitis

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Tea residues are rich in dietary fiber, most of which insoluble fiber (IDF). However, soluble (SDF) is reported to show a better health-promoting effect. In this paper, the Eurotium cristatum (E. cristatum) fermentation method was employed prepare SDF from tea residues. The results showed that yield fermented (FSDF) higher than unfermented (USDF). Meanwhile, an increased proportion galactose and looser microstructure were observed FSDF. addition, FSDF has more advantages USDF relieving colitis symptoms. effective reversing weight loss, colon shortening, tissue damage. it regulatory effect on level inflammatory factors (IL-6, IL-1β, TNF-α, IL-10) oxidative stress (CAT, T-SOD, MDA). treatment effectively restored gut microbiota composition toward normal parameters compared by upregulating Akkermanisa Lachospiracae_NK4A136_group downregulating Helicobacter Alisitipes. conclusion, with E. contributed preparation efficiency bioactive This study will provide theoretical basis for development utilization

Язык: Английский

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Protective effects of insoluble dietary fiber from cereal bran against DSS-induced chronic colitis in mice: From inflammatory responses, oxidative stress, intestinal barrier, and gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137846 - 137846

Опубликована: Ноя. 18, 2024

Язык: Английский

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Effects of water-insoluble wheat bran-fraction powder on disease activity and caecal microbiota in dextran sodium sulphate-induced inflammatory bowel disease mouse model

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Ноя. 1, 2024

Язык: Английский

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