Applied Biological Chemistry,
Год журнала:
2024,
Номер
67(1)
Опубликована: Май 30, 2024
Abstract
Background
Trimethylamine-N-Oxide
(TMAO)
is
believed
to
be
linked
increased
likelihood
of
cardiovascular
disease.
While
probiotics
have
shown
limited
effectiveness
in
reducing
TMAO
levels,
the
potential
postbiotics
remains
underexplored.
This
study
aimed
evaluate
impact
Akkermansia
muciniphila
(
A.
)
postbiotic
administration
on
choline-induced
production
mice
by
modifying
gut
microbiota.
Methods
Female
C57BL/6J
were
divided
into
six
groups,
including
a
control
group,
high-choline
diet
live
probiotic
pasteurized
sodium
butyrate
and
propionate
group.
Various
measurements
analyses
conducted,
TMA
levels
serum,
urine,
cecal
contents,
as
well
expression
FXR
FMO3
liver
tissues.
Additionally,
metabolic
parameters,
body
weight,
serum
lipid
profile,
hepatic
protein
(FMO3,
FXR,
CutC,
CutD),
microbiota
composition
assessed.
Results
Administration
significantly
reduced
plasma
mice.
Furthermore,
improvements
profiles
enzyme
suggested
enhancements
metabolism
function.
The
also
observed
modulation
specific
proteins
related
metabolism,
CutC
CutD.
Conclusion
findings
highlight
dietary
strategy
for
mitigating
disease
risk
modulating
gut-TMAO
axis.
Postbiotics,
particularly
,
offer
advantages
over
warrant
further
investigation
their
therapeutic
applications
gastrointestinal
disorders.
Graphical
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 20, 2024
Metabolic
diseases
are
comprehensive
disease
based
on
obesity.
Numerous
cumulative
studies
have
shown
a
certain
correlation
between
the
fluctuating
abundance
of
Akkermansia
muciniphila
and
occurrence
metabolic
diseases.
A.
,
potential
probiotic
candidate
colonized
in
human
intestinal
mucus
layer,
its
derivatives
various
physiological
functions,
including
treating
disorders
maintaining
health.
This
review
systematically
explicates
change
rules
It
also
details
high
efficacy
specific
molecules
mechanism
obesity,
type
2
diabetes
mellitus,
cardiovascular
disease,
non-alcoholic
fatty
liver
disease.
Brain Sciences,
Год журнала:
2024,
Номер
14(3), С. 238 - 238
Опубликована: Фев. 29, 2024
Increasing
evidence
suggests
that
the
gut
microbiota
may
represent
potential
strategies
for
Parkinson’s
disease
(PD)
treatment.
Our
previous
research
revealed
a
decreased
abundance
of
Akkermansia
muciniphila
(Akk)
in
PD
mice;
however,
whether
Akk
is
beneficial
to
unknown.
To
answer
this
question,
mice
received
MPTP
intraperitoneally
construct
subacute
model
and
were
then
supplemented
with
orally
21
consecutive
days.
Motor
function,
dopaminergic
neurons,
neuroinflammation,
neurogenesis
examined.
In
addition,
intestinal
inflammation,
serum
fecal
short-chain
fatty
acids
(SCFAs)
analyses,
assessed.
We
found
treatment
effectively
inhibited
reduction
neurons
substantia
nigra
pars
compacta
(SNpc)
partially
improved
motor
function
mice.
Additionally,
markedly
alleviated
neuroinflammation
striatum
hippocampus
promoted
hippocampal
neurogenesis.
It
also
level
colon
inflammation.
Furthermore,
these
aforementioned
changes
are
mainly
accompanied
by
alterations
isovaleric
acid
levels,
lower
permeability.
strongly
neuroprotective
agent
therapy.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 14, 2025
Hepatocellular
carcinoma
(HCC)
is
the
most
frequently
occurring
type
of
liver
tumor
and
considered
one
common
primary
malignant
neoplasms.
The
prognosis
for
HCC
dismal
because
its
complicated
etiology
high
level
medication
resistance.
Immunotherapy
presently
regarded
as
effective
therapeutic
options
HCC;
nevertheless,
disturbance
intestinal
flora,
immunotherapy
shows
low
antitumor
efficacy.
An
increasing
body
research
indicates
that
particularly
Akkermansia
muciniphila
(
A.
),
vital
treatment
tumors.
Studies
have
demonstrated
diminished
effectiveness
in
cancer
patients
associated
with
a
reduction
levels,
suggesting
levels
significantly
enhance
efficacy
immunotherapy.
functions
gut
probiotic
can
treat
prevent
wide
range
illnesses,
including
cancer.
Consequently,
preserving
abundance
enough
to
lower
danger
developing
disorders.
In
this
review,
we
critically
evaluate
current
on
,
focus
biological
properties
functions.
different
illnesses
treats
were
then
discussed,
way
it
works
This
review
aims
give
novel
plan
well
theoretical
foundation
improving
Animals,
Год журнала:
2023,
Номер
14(1), С. 113 - 113
Опубликована: Дек. 28, 2023
In
this
study,
we
investigated
the
variations
in
production
performance,
health
status,
and
gut
microbiota
of
meat
rabbits
raised
semi-confined
barn
during
summer
winter.
Compared
to
summer,
reared
winter
possessed
significantly
higher
slaughter
weight
carcass
weight.
Rabbits
fed
were
more
vulnerable
different
stressors,
which
led
increased
protein
levels
HSP90,
IL-1α,
IL-1β,
IL-2,
concentrations
MDA,
but
declined
GSH
SOD
activities.
Additionally,
significant
differences
microbial
communities
observed.
winter,
had
lower
alpha
beta
diversity.
Both
Firmicutes
Verrucomicrobiota
dominant
phyla,
they
accounted
for
greater
proportions
than
summer.
At
taxa
levels,
several
seasonal
differentially
enriched
microbes
identified,
such
as
Akkermansia
muciniphila,
Oscillospiraceae
NK4A214
group,
Christensenellaceae
R-7
Alistipes,
Muribaculaceae.
Functional
capacities
linked
proliferation,
nutrient
metabolism,
environmental
adaptive
responses
exhibited
abundances
between
Moreover,
strong
interactions
among
indicators
presented.
Based
on
our
findings,
not
only
proposed
potential
strategies
ameliorate
undesirable
effects
changes
productivity
also
underscored
directions
future
mechanistic
studies
adaptation
physiology.
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
289, С. 117625 - 117625
Опубликована: Янв. 1, 2025
Exposure
of
PM2.5
can
cause
different
degrees
lung
injury,
which
is
referred
with
inflammatory
response.
Some
evidences
showed
that
low-dose
radiation
(LDR)
induces
hormesis
in
immune,
however,
it
unknown
if
LDR
ameliorates
the
PM2.5-induced
injury.
Additionally,
gut
microbiota
and
inflammation
are
crucial
injury
health
benefits
through
need
further
exploration.
Here,
we
aim
to
investigate
impact
on
vivo
vitro,
elucidated
potential
mechanisms
anti-inflammation
activated
by
microbiota.
We
observed
ameliorated
damage
induced
mice.
after
exposure,
M1
polarization
macrophages
alveolar
lavage
fluid
Th1
spleen
increased,
pro-inflammatory
cytokines
(IL-1,
IL-6
TNF-α)
increased
anti-inflammatory
(IL-4,
IL-10
TGF-β)
decreased
serum.
could
deteriorate
changes
described
as
above.
Intriguingly,
Akkermansia
muciniphila
(Akk)
differed
most
significantly
Notably,
Toll-like
receptors-induced
MyD88/NF-κB
pathways
mediate
pro-inflammation,
inhibited
pathway.
However,
TLR1
TLR2
continuously
LDR,
indicating
downstream
non-canonical
TLR1/TLR2
pathway
Akk
was
blunt
pro-inflammation
PM2.5.
Our
results
strongly
indicate
LDR-induced
activation
Akk-dependent
TLR1/TLR2-like
receptor
resulted
from
