Complex Probiotics Suppress Inflammation by Regulating Intestinal Metabolites in Kittens
Animals,
Год журнала:
2025,
Номер
15(2), С. 272 - 272
Опубликована: Янв. 19, 2025
Cats
are
popular
companions
for
humans,
and
their
health
is
of
importance
to
a
growing
number
pet
owners.
The
juvenile
period
critical
stage
cat
growth;
in
particular,
the
metabolic
activity
intestinal
microbiome
kittens
processing
nutrients
supporting
overall
health.
In
this
study,
effect
complex
probiotics
on
was
explored
through
metabolomics
analysis.
Twenty-four
healthy
were
randomly
assigned
two
groups
(n
=
12):
control
group
provided
basal
diet
supplemented
with
(given
at
same
time
daily).
acclimatized
5
days,
experiment
conducted
14
days.
We
collected
feces
from
each
kitten
days
1
metabolomic
analyses.
Compared
control,
had
significantly
higher
(p
<
0.05)
methylmalonylcarnitine,
lysyl-hydroxyproline,
phenylpropionylglycine,
vitamin
K3
levels,
lower
gamma-glutamyl-L-putrescine,
cis-gondoic
acid,
myristic
12,13-DiHOME,
glycodeoxycholic
acid
levels.
results
study
suggest
that
promote
by
regulating
changes
various
metabolites
intestine
may
have
mitigating
inflammation.
Язык: Английский
Growth Characteristics of Peanut (Arachis hypogaea L. cv. Sinpalkwang) as Influenced by Irrigation Frequency and Temperature Conditions
Journal of Biosystems Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Moderate Highland Barley Intake Affects Anti-Fatigue Capacity in Mice via Metabolism, Anti-Oxidative Effects and Gut Microbiota
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 733 - 733
Опубликована: Фев. 19, 2025
this
study
aimed
to
explore
the
effects
of
different
intake
levels
(20-80%)
highland
barley
on
anti-fatigue
capacity
ICR
mice,
focusing
energy
metabolism,
metabolite
accumulation,
oxidative
stress,
and
changes
in
gut
microbiota.
male
mice
were
assigned
five
groups:
control
(normal
diet)
four
experimental
groups
with
supplementation
at
20%,
40%,
60%,
80%
total
dietary
energy.
Anti-fatigue
performance
was
assessed
by
behavioral
experiments
(rotarod,
running,
exhaustive
swimming
tests),
biochemical
markers,
microbiota
analysis.
results
showed
that
moderate
(20%)
significantly
enhanced
exercise
endurance
capacity,
as
evidenced
increased
liver
glycogen
(134.48%),
muscle
(87.75%),
ATP
content
(92.07%),
Na+-K+-ATPase
activity
(48.39%),
antioxidant
enzyme
activities
(superoxide
dismutase
(103.31%),
catalase
glutathione
peroxidase
(81.14%).
Post-exercise
accumulation
blood
lactate,
quadriceps
serum
urea
nitrogen,
stress
marker
malondialdehyde
reduced,
differences
31.52%,
21.83%,
21.72%,
33.76%,
respectively.
Additionally,
20%
promoted
growth
beneficial
associated
effects,
including
unclassified_f_Lachnospiraceae,
g_norank_f_Peptococcaceae,
Lachnospiraceae
NK4A136,
Colidextribacter,
Turicibacter.
However,
when
reached
60%
or
more,
diminished,
decreased
activity,
metabolic
waste,
a
rise
potentially
harmful
(Allobaculum,
Desulfovibrio,
norank_f_norank_o_RF39).
(20%
energy)
enhances
while
excessive
(≥60%)
may
have
adverse
effects.
Язык: Английский
Soybean Sprout Peptides Alleviate Obesity via PI3K-Akt and JAK-STAT Pathway Modulation, Gut Microbiota Regulation, and Metabolic Reprogramming
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Obesity
is
a
growing
global
health
concern
associated
with
severe
metabolic
disorders,
necessitating
the
development
of
safer
and
more
effective
therapeutic
strategies.
Soybean
sprout
peptides
(SSPs),
derived
from
germinated
soybeans,
are
bioactive
compounds
potential
antiobesity
effects.
This
study
aimed
to
investigate
molecular
mechanisms
SSPs
through
an
integrated
approach
combining
network
pharmacology,
docking,
in
vivo
experiments.
SSP
sequences
were
identified
using
UPLC-Orbitrap-MS/MS,
their
bioactivity
was
predicted
PeptideRanker.
Network
pharmacology
key
targets,
including
AKT1,
SRC,
STAT3,
ESR1,
FOS,
NFKB1,
which
implicated
PI3K-Akt
JAK-STAT
pathways.
Molecular
docking
validated
strong
interactions
between
these
targets.
In
vivo,
administration
significantly
reduced
body
weight
gain,
abdominal
fat
accumulation,
serum
lipid
abnormalities
high-fat-diet-induced
obese
mice
while
modulating
gut
microbiota
composition
by
restoring
Firmicutes-to-Bacteroidetes
ratio
reducing
pathogenic
taxa.
Fecal
metabolomics
revealed
that
alleviated
oxidative
stress
improved
amino
acid
metabolism,
contributing
its
These
findings
suggest
holds
promise
as
functional
food
ingredient
or
nutraceutical
for
obesity
prevention
management.
Язык: Английский
Genomics and physiology of Catenibacillus, human gut bacteria capable of polyphenol C-deglycosylation and flavonoid degradation
Microbial Genomics,
Год журнала:
2024,
Номер
10(5)
Опубликована: Май 24, 2024
The
genus
Catenibacillus
(family
Lachnospiraceae
,
phylum
Bacillota
)
includes
only
one
cultivated
species
so
far,
scindens,
isolated
from
human
faeces
and
capable
of
deglycosylating
dietary
polyphenols
degrading
flavonoid
aglycones.
Another
intestinal
strain
not
taxonomically
resolved
at
that
time
was
recently
genome-sequenced.
We
analysed
the
genome
this
novel
isolate,
designated
decagia
showed
its
ability
to
deglycosylate
C
-coupled
flavone
xanthone
glucosides
O
glycosides.
Most
resulting
aglycones
were
further
degraded
corresponding
phenolic
acids.
Including
sequenced
C.
scindens
ten
faecal
metagenome-assembled
genomes
assigned
we
performed
a
comparative
analysis
searched
for
genes
encoding
potential
-glycosidases
other
polyphenol-converting
enzymes.
According
data
physiological
characterization,
core
metabolism
strains
is
based
on
fermentative
lifestyle
with
butyrate
production
hydrogen
evolution.
Both
encode
-glycosidase,
reductase,
flavanone/flavanonol-cleaving
reductase
phloretin
hydrolase.
Several
gene
clusters
enzymes
similar
those
-deglycosylation
system
Dorea
PUE
(DgpBC),
while
separately
located
putative
polyphenol-glucoside
oxidases
(DgpA)
required
-deglycosylation.
diversity
dgpA
dgpBC
might
explain
broad
-glycoside
substrate
spectrum
.
few
flavonoid-converting
Our
results
indicate
several
are
well-equipped
degrade
plant
inhabit
corresponding,
specific
niche
in
gut.
Язык: Английский