The genetic associations between gut microbiota and menstruation quality of life impacts in the East Asian women DOI Creative Commons
Yuhang Zhou, Yue Wang,

Yun Feng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 23, 2024

Abstract Background Menstruation affects the physiological and psychological health of East Asian women, imposing burdens on their daily lives work. The gut microbiota has been found to improve various diseases. study used Mendelian randomization exploratorily discuss causal effects menstruation quality life impacts. Methods According predefined threshold, independent genetic variants significantly linked 119 bacterial genera in were extracted as instrumental variables. inverse variance weighted (IVW) was utilized primary analysis method, supplemented by MR-Egger Weighted median methods. Effect estimates assessed primarily using odds ratios (OR) 95% confidence intervals (95%CI). In addition, sensitivity analyses (heterogeneity, horizontal pleiotropy, outliers) implemented evaluate robustness accuracy findings. Results Causal between 28 13 Based OR, 18 identified risk factors, while 10 protective factors. Furthermore, did not detect heterogeneity, or outliers. Conclusions This provides evidence for These findings will help elucidate how could affect issues during menstruation. they also offer valuable perspectives into management women's

Язык: Английский

Modulatory impact of Bifidobacterium longum subsp. longum BL21 on the gut–brain–ovary axis in polycystic ovary syndrome: insights into metabolic regulation, inflammation mitigation, and neuroprotection DOI Creative Commons
Yao Dong,

Shengnan Yang,

Shu Zhang

и другие.

mSphere, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

ABSTRACT This study evaluates the efficacy of Bifidobacterium longum subsp. BL21 in mitigating symptoms polycystic ovarian syndrome (PCOS) DHT-induced PCOS model mice. It focuses on BL21’s role modulating metabolic dysregulation, inflammation, and neuroprotection via gut–brain–ovary axis. Employing an 8-week treatment regimen, this research assessed effects prenatal androgen-induced ICR Evaluations included body weight, glucose tolerance tests, serum analyses BDNF, inflammatory markers, sex hormone levels, 16S rRNA gene sequencing for gut microbiota diversity composition. Twenty-four mice with induced served as subjects to examine probiotic’s impact. Mice were administered a daily oral dose 1 × 10 9 CFU continuously total 8 weeks. significantly enhanced levels ( P < 0.05), particularly those follicle-stimulating (FSH) estradiol (E2), indicating improved function offering novel approach. The intervention notably curbed weight gain 0.05). reduced markers such interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), lipopolysaccharides (LPS), while increasing IL-10, FSH, E2 0.05 all). also enriched diversity, enhancing populations Lactobacillus . Correlation underscored positive shifts linked beneficial hormonal profiles. shows promise alleviating through regulation, inflammation reduction, neuroprotection, validating its potential integrated therapeutic strategies. IMPORTANCE Polycystic is prevalent endocrine disorder affecting women reproductive age, characterized by irregularities, imbalances, chronic inflammation. Existing treatments are often inadequate, addressing without targeting underlying etiological factors. investigation probiotic offers approach potentially regulating could lead innovative strategies that not only manage but reverse multifaceted PCOS, quality life health.

Язык: Английский

Процитировано

1
Exploring the causal associations of the gut microbiota and plasma metabolites with ovarian cancer: an approach of mendelian randomization analysis combined with network pharmacology and molecular docking DOI Creative Commons

Junfeng Guo,

Chen Wang, He Li

и другие.

Journal of Ovarian Research, Год журнала: 2025, Номер 18(1)

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

0
Boosting Antioxidant Defense and Enhancing Product Quality by Biochar and Probiotics under Chronic Aflatoxicosis in Quails DOI Creative Commons

Majid Raz,

Farzad Bagherzadeh‐Kasmani, Mohammad Amir Karimi Torshizi

и другие.

Poultry Science, Год журнала: 2025, Номер 104(7), С. 105183 - 105183

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

0
Maternal co-exposure to Cd and PS-NPLs induces offspring ovarian inflammatory aging via promoting M1 macrophage polarization DOI

Ruiying Zhang,

Penghui Nie,

Yuankun Zhou

и другие.

Chemico-Biological Interactions, Год журнала: 2025, Номер 416, С. 111535 - 111535

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0
Association between endogenous estradiol, testosterone, and long‐term mortality in adults with prediabetes and diabetes: Evidence from NHANES database DOI Creative Commons
Feng Ye, Xi Jin,

Zhu Jing

и другие.

Journal of Diabetes Investigation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

ABSTRACT Aim and Introduction Diabetes prediabetes pose significant global public health challenges. Sex steroids, particularly testosterone estradiol, play crucial roles in various metabolic processes. This study investigates the relationship between sex hormone levels long‐term mortality adults with diabetes, as well those without glucose intolerance. Material Methods retrospective cohort utilized data from NHANES 2013–2016, including aged 50–79 across prediabetic, diabetic, non‐diabetic groups. Serum testosterone, their ratios (T/E) were analyzed. The primary outcomes all‐cause CVD tracked until December 2019. Cox regression models estimated associations risks. Results included 3,665 participants (male: 2,140; female: 1,775). In males prediabetes, higher estradiol (adjusted hazard ratio [aHR] = 0.17, 95% confidence interval [CI]: 0.07–0.43) or (aHR 0.39, CI: 0.31–0.50) was significantly associated lower risk of mortality. Higher 0.12, 0.04–0.32) 0.36, 0.27–0.48) risk. females there a association 0.22, 0.06–0.83) T/E 0.18, 0.04–0.73) reduced Conclusions identifies some novel men women different glycemic statuses. These findings suggest potential protective role hormones individuals altered metabolism, gender difference, warranting further investigation.

Язык: Английский

Процитировано

1
The genetic associations between gut microbiota and menstruation quality of life impacts in the East Asian women DOI Creative Commons
Yuhang Zhou, Yue Wang,

Yun Feng

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 23, 2024

Abstract Background Menstruation affects the physiological and psychological health of East Asian women, imposing burdens on their daily lives work. The gut microbiota has been found to improve various diseases. study used Mendelian randomization exploratorily discuss causal effects menstruation quality life impacts. Methods According predefined threshold, independent genetic variants significantly linked 119 bacterial genera in were extracted as instrumental variables. inverse variance weighted (IVW) was utilized primary analysis method, supplemented by MR-Egger Weighted median methods. Effect estimates assessed primarily using odds ratios (OR) 95% confidence intervals (95%CI). In addition, sensitivity analyses (heterogeneity, horizontal pleiotropy, outliers) implemented evaluate robustness accuracy findings. Results Causal between 28 13 Based OR, 18 identified risk factors, while 10 protective factors. Furthermore, did not detect heterogeneity, or outliers. Conclusions This provides evidence for These findings will help elucidate how could affect issues during menstruation. they also offer valuable perspectives into management women's

Язык: Английский

Процитировано

0