Recent advances in the extraction, purification and analytical techniques for flavonoids from plants: Taking hawthorn as an example
Journal of Food Composition and Analysis,
Год журнала:
2025,
Номер
unknown, С. 107372 - 107372
Опубликована: Фев. 1, 2025
Язык: Английский
Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
ABSTRACT
Obesity,
along
with
its
associated
health
risks
such
as
hypertension,
hyperlipidemia,
Type
2
diabetes,
stroke,
metabolic
syndrome,
asthma,
and
cancer,
constitutes
a
significant
global
burden,
contributing
substantially
to
morbidity
mortality.
Cytokines,
group
of
secreted
signaling
proteins,
are
crucial
in
initiating,
maintaining,
resolving
immune
responses.
Although
cytokines
have
unique
advantages
regulating
functions,
their
therapeutic
application
for
obesity
remains
limited
clinical
practice.
Natural
compounds,
known
structural
diversity
low
toxicity,
become
valuable
resource
drug
development.
Many
natural
compounds
shown
anti‐obesity
effects.
This
review
comprehensively
examines
the
mechanisms
underlying
obesity,
specific
focus
on
roles
cytokines,
inflammatory
adipokines,
growth
factors.
Additionally,
it
highlights
regulatory
interactions
between
gut
microbiota
obesity.
The
critically
analyzes
current
pharmacological
interventions
summarizes
advanced
methodologies
identifying
potential
compounds.
Finally,
identifies
promising
that
modulate
cytokine
activity
prevent
or
treat
assesses
complementary
alternative
therapies.
Язык: Английский
Effects of natural products on macrophage immunometabolism: a new frontier in the treatment of metabolic diseases
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107634 - 107634
Опубликована: Янв. 1, 2025
Язык: Английский
Simultaneously phytochemical characteristic interpretation and efficient extraction of bioactive polar substances in Phragmites australis
Microchemical Journal,
Год журнала:
2025,
Номер
unknown, С. 113880 - 113880
Опубликована: Май 1, 2025
Язык: Английский
Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine
Alzheimer s Research & Therapy,
Год журнала:
2025,
Номер
17(1)
Опубликована: Май 13, 2025
Oxysterols,
gut
metabolites,
and
N6-methyladenosine
(m6A)
are
extensively
implicated
in
the
pathogenesis
of
cognitive
dysfunction,
while
their
alterations
different
stages
mild
impairment
(MCI)
have
not
been
elucidated.
Therefore,
this
study
was
conducted
to
explore
associations
oxysterols,
m6A
methylation
profiles
early
MCI
(EMCI)
late
(LMCI)
individuals.
Liquid
chromatography-mass
spectrometry,
untargeted
metabolomic
analysis,
mRNA
Epitranscriptomic
Microarray
were
used
detect
characteristics
serum
oxysterols
(n
=
35/group),
fecal
metabolites
30/group),
whole
blood
4/group)
respectively.
The
concentration
β-amyloid
(Aβ)
detected
with
ELISA
25/group).
gene
expression
amyloid
precursor
protein
(APP)
its
key
enzyme
β-secretase
(BACE1)
measured
by
quantitative
real-time
PCR
EMCIs
LMCIs,
especially
exhibited
poorer
performance
almost
all
global
multidimensional
tests.
Serum
27-hydroxycholesterol
(27-OHC)
24S-hydroxycholesterol
(24S-OHC)
elevated
EMCI
LMCI
groups.
Changes
occurred
mainly
group,
which
several
including
Procyanidin
dimer
B7
Phorbol
myristate,
significantly
decreased.
landscape
LMCIs
obviously
differed
from
Controls.
Hypomethylated
mRNAs
accounted
for
majority
accompanied
downregulated
mRNAs,
consistent
writer
methyltransferase-like
4
(METTL4).
27-OHC
24S-OHC
combined
various
distinguished
between
subgroups
healthy
controls
(EMCI/Control:
AUC
0.877;
LMCI/Control:
0.952).
Heatmap
revealed
correlation
myristate
differentially
m6A-methylated
mRNAs.
Differentially
expressed
methylated
commonly
enriched
34
KEGG
metabolic
pathways,
cholesterol
metabolism
neurodegenerative
disease-related
pathways.
Our
explored
altered
MCI.
potential
function
aberrant
driving
progression
warrants
further
mechanistic
investigation.
Язык: Английский