LPL-RH suppresses bone loss in ovariectomised rat models DOI Creative Commons
Wen‐jie Chen,

Xinliang Wang,

Yufan Wang

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 28, 2024

Evidence has revealed that oestrogen deprivation-induced osteolysis is microbiota-dependent and can be treated by probiotics. However, the underlying mechanism require further investigation. This study aims to provide additional evidence supporting use of probiotics as an adjuvant treatment explore pathophysiology oestrogen-deprived osteolysis. Forty-five SD rats were randomly divided into five groups (n = 9). Rats from four ovariectomised with NS, calcium, probiotics, or calcium + while one group underwent a sham operation was NS. The osteometabolic effects evaluated, mechanistic role probiotic supplement explored. Intragastric administration Bifidobacterium animalis subsp. lactis LPL-RH (LPL-RH) markedly suppressed osteoclastic activation bone loss downregulating TRAP enzymatic activity, OPG/RANKL ratio, downstream signalling pathway RANKL/TRAF6/NF-κB/NFATc1/TRAP in rats. also reduced CD4+IL-17 A+ TH17 cells marrow, pro-osteoclastogenic cytokine IL-17 A, pro-inflammatory molecules (LPS), its binding protein (LBP) blood. restored intestinal ZO-1, occludin, claudin 2, 12, 15, which improved ileal histopathology, oxidative stress, attenuated LPS-responsive TLR4/MyD88/NF-κB pathway. Furthermore, 16 S rRNA sequencing altered faecal microbiome reducing relative abundance S24-7 at family level promoting Prevotella Bacteroides genus level. Collectively, osteoclastogenesis modulating type 17 immunity gut microbiome.

Язык: Английский

Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses DOI Creative Commons

Yanfang Lan,

Yaonan Li,

Yang Wang

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Март 12, 2025

In recent years, the importance of gut microbiota in digestive absorption, metabolism, and immunity has garnered increasing attention. China possess abundant horse breed resources, particularly Guizhou horses, which play vital roles local agriculture, tourism, transportation. Despite this, there is a lack comparative studies on native horses (GZH) imported Dutch Warmblood (WH). To address this gap, fecal samples were collected from both GZH WH, 16S rRNA high-throughput sequencing was utilized to analyze differences their microbiota. The results indicated that compared with GZH, abundance bacterial community WH significantly higher, whereas fungal lower. Furthermore, PCoA-based scatter plot analysis demonstrated distinct structure bacteria fungi between two breeds. While types share similar major phyla, significant observed numerous genera. Moreover, functional predictions communities suggested exhibit more robust system enhanced glycan biosynthesis metabolism capabilities. This first report WH. emphasize among various breeds offer valuable insights into composition different

Язык: Английский

Процитировано

0
Gegen-Qinlian decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating the microbiota-bile acid axis in mice DOI

Xiangbing Shu,

Ying Cao,

Yan Wu

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119719 - 119719

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Potential of Kefir-Derived Peptides, Probiotics, and Exopolysaccharides for Osteoporosis Management DOI Creative Commons

Jen‐Chieh Lai,

Gary Ro‐Lin Chang,

Min‐Yu Tu

и другие.

Current Osteoporosis Reports, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 7, 2025

Osteoporosis is a prevalent skeletal disorder in postmenopausal women and older adults. Kefir has gained attention for its potent antioxidative, anti-inflammatory, immunomodulatory properties. This review consolidates findings on kefir-derived peptides' interventions osteoporosis models evaluates the therapeutic potential of kefir components preventing osteoporosis, thereby enhancing application clinical nutrition strategies management. Kefir-derived peptides exhibit osteoprotective various animal which several antioxidative ACE-inhibitory have been shown to promote osteoblast differentiation mineralization. In addition, emerging evidence supports role probiotics exopolysaccharides (kefiran) mitigating bone loss. holds significant promise management due unique composition bioactive promoting health. While research still early stages, suggests kefir's as natural approach prevention

Язык: Английский

Процитировано

0
Microbiota and Resveratrol: How Are They Linked to Osteoporosis? DOI Creative Commons
C. Meyer, Aranka Brockmueller, Vicenç Ruiz de Porras

и другие.

Cells, Год журнала: 2024, Номер 13(13), С. 1145 - 1145

Опубликована: Июль 3, 2024

Osteoporosis (OP), which is characterized by a decrease in bone density and increased susceptibility to fractures, closely linked the gut microbiota (GM). It increasingly realized that GM plays key role maintenance of functioning multiple organs, including bone, producing bioactive metabolites such as short-chain fatty acids (SCFA). Consequently, imbalances GM, referred dysbiosis, have been identified with significant reduction beneficial metabolites, decreased SCFA associated chronic inflammatory processes, activation NF-κB at epigenetic level, recognized main cause many diseases, OP. Furthermore, regular or long-term medications antibiotics non-antibiotics proton pump inhibitors, chemotherapy, NSAIDs, found contribute development highlighting an urgent need for new treatment approaches. A promising preventive adjuvant approach combat dysbiosis natural polyphenols resveratrol, prebiotic functions ensure optimal microenvironment GM. Resveratrol offers range benefits, anti-inflammatory, anti-oxidant, analgesic, effects. In particular, has shown convert into highly metabolically active molecules even more potent properties, supporting synergistic polyphenol–GM axis. This review addresses question how can enhance effects resveratrol modulator, promote growth diversity thus providing important insights prevention co-treatment

Язык: Английский

Процитировано

2
From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management DOI Creative Commons

Linjie Hao,

Yuzhu Yan, Guilin Huang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Сен. 25, 2024

Osteoporosis (OP) is characterized by decreased bone mineral density (BMD) and increased fracture risk, poses a significant global health burden. Recent research has shed light on the bidirectional relationship between gut microbiota (GM) health, presenting novel avenue for understanding OP pathogenesis developing targeted therapeutic interventions. This review provides comprehensive overview of GM-bone axis, exploring impact GM development management. We elucidate established risk factors OP, delve into diversity functional changes in OP. Furthermore, we examine experimental evidence clinical observations linking alterations composition or function with variations BMD risk. Mechanistic insights microbial mediators such as metabolites products, are discussed. Therapeutic implications, including GM-targeted interventions dietary strategies, also explored. Finally, identify future directions challenges translating these findings practice.

Язык: Английский

Процитировано

2
Improvement in Noodle Quality and Changes in Microstructure and Disulfide Bond Content through the Addition of Pepper Straw Ash Leachate DOI Creative Commons
Xinyang Li, Yongjun Wu, Li Cen

и другие.

Foods, Год журнала: 2024, Номер 13(10), С. 1562 - 1562

Опубликована: Май 16, 2024

Every year, a significant amount of pepper stalks are wasted due to low utilization. The ash produced from contains alkaline salts, which food additives that can enhance the quality noodles. Therefore, utilizing natural straw improve noodles shows promising development prospects. In this study, leachate (PSAL) was extracted and added gradually improved with addition PSAL, best effect observed at concentration 18% (PSAL mass/flour mass). This resulted in 57.8% increase noodle hardness, 55.43% chewiness, 19.41% rise water absorption rate, 13.28% disulfide bond content. These alterations rendered more resilient during cooking, reducing their tendency soften thus enhancing chewiness palatability. Incorporating PSAL also reduced cooking loss by 57.79%. Free sulfhydryl groups decreased 5.1%, scanning electron microscopy revealed denser gluten network structure noodles, complete starch wrapping. study significantly enhanced provided new pathway for application resources industry.

Язык: Английский

Процитировано

1
Sea Cucumber Intestinal Osteotropic Peptide Promotes Tibial Fracture Healing in Osteoporotic Mice by Promoting Glutamine Metabolism DOI

Haowen Yin,

Sun Jin Hur, Tianqi Zhang

и другие.

Food Bioscience, Год журнала: 2024, Номер 60, С. 104370 - 104370

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

1
Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study DOI Creative Commons
Haiyang Wu,

Zaijie Sun,

Qiang Guo

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Июль 10, 2024

Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.

Язык: Английский

Процитировано

0
Oral supplementation with Bifidobacterium infantis and 2′-fucosyllactose revives gut microbiota perturbation and intestinal and immune developmental delay following early-life antibiotic challenge in BALB/c mice DOI Creative Commons
Yating Luo, Jinxing Li,

Simou Wu

и другие.

Journal of Dairy Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk DOI
Yaping Zheng, Shasha Cheng, Hongxuan Li

и другие.

Food & Function, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Lacticaseibacillus paracasei JM053 has the ability to convert soy isoflavone aglycones highly and can be used for fermented soymilk alleviate osteoporosis.

Язык: Английский

Процитировано

0