Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing DOI Creative Commons
Natalie Marie Petryk,

Nghia Le Ba Thai,

Leo Vikram Saldanha

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Polyurethane (PUr) shape memory polymer (SMP) foams have demonstrated excellent bleeding control in traumatic wounds. Unlike the current clinically available treatment options, PUr SMP can address noncompressible bleeds, are safe for prolonged use, and highly tunable, offering broad functionalities like biodegradation antimicrobial properties. Despite their hemostatic efficacy, PUrs entirely synthetic, which limits long-term healing capacity if left a wound to degrade. This work employed methods facile incorporation of bioactive collagen gelatin into postfabrication enhance clotting efficacy drive cell interactions. The procoagulant nature increased accomplished by foams. Additionally, promoted attachment, spreading, proliferation on foam pores, could facilitate tissue migration scaffold promote repair. Overall, dressing significantly improve outcomes.

Язык: Английский

Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing DOI Creative Commons
Natalie Marie Petryk,

Nghia Le Ba Thai,

Leo Vikram Saldanha

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Polyurethane (PUr) shape memory polymer (SMP) foams have demonstrated excellent bleeding control in traumatic wounds. Unlike the current clinically available treatment options, PUr SMP can address noncompressible bleeds, are safe for prolonged use, and highly tunable, offering broad functionalities like biodegradation antimicrobial properties. Despite their hemostatic efficacy, PUrs entirely synthetic, which limits long-term healing capacity if left a wound to degrade. This work employed methods facile incorporation of bioactive collagen gelatin into postfabrication enhance clotting efficacy drive cell interactions. The procoagulant nature increased accomplished by foams. Additionally, promoted attachment, spreading, proliferation on foam pores, could facilitate tissue migration scaffold promote repair. Overall, dressing significantly improve outcomes.

Язык: Английский

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