Stereoselective Synthesis of acyclic (Z)-3-Haloallylamines via a Multicomponent Reaction of Propargylic Alcohols, TMSX and Sulfonamides DOI
Shuai He, Lijuan Wu, Yan Yin

и другие.

Tetrahedron, Год журнала: 2024, Номер 163, С. 134146 - 134146

Опубликована: Июль 15, 2024

Язык: Английский

EXPLORING AZETIDINE CONTAINING HETEROCYCLES: FROM GREEN SYNTHESIS TO APPLICATIONS DOI
Shivangi Jaiswal,

Nikhilesh Arya,

Dharma Kishore

и другие.

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134491 - 134491

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Visible Light-Promoted Three-Component Reaction for the Synthesis of Pyrrolopyrazoles DOI

Han‐Peng Pan,

Shao‐Shuai Chen,

Han Yang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

A visible light-enabled three-component cascade assembles pyrrolopyrazoles from arylalkynes, benzoquinones, and 5-aminopyrazole through a mechanistically validated carbonyl-alkyne metathesis/(3 + 2)-cycloaddition/1,2-aryl migration sequence. This protocol delivers pyrrolopyrazole heterocycles in up to 96% yield with excellent functional group tolerance. Preliminary biological screening identified promising antitumor activity selected products, highlighting the potential value of this method. The proposed reaction mechanism is supported by control experiments.

Язык: Английский

Процитировано

0
Access to 4‐Membered Heterocycles via Visible‐Light Triggered Intramolecular Cyclization from Alkynes: Bypassing Unfavorable 4‐endo‐dig Cyclization DOI
Arun Sharma,

Ahhyeon Choi,

Daniel Yim

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(10), С. 2257 - 2263

Опубликована: Апрель 5, 2024

Abstract We describe a catalyst, oxidant, and coupling‐reagent free strategy to access 4‐membered heterocycles, representing unique example of visible‐light triggered intramolecular cyclization propargylic alcohols amines oxetanones azetidinones respectively. Despite the direct 4‐endo‐dig from these starting materials has proven be unfavorable, formation key p ‐quinone methide intermediacy allows an efficient bypass for regioselective 4‐exo‐trig cyclization, resulting in desired heterocycles. This mild operationally simple protocol facilitates synthesis products with distinct substitution patterns such as quaternary α‐carbons, enables late‐stage functionalization.

Язык: Английский

Процитировано

1
Stereoselective Synthesis of Acyclic (Z)-3-Haloallylamines Via a Multicomponent Reaction of Propargylic Alcohols, Tmsx and Sulfonamides DOI
Shuai He, Lijuan Wu, Yan Yin

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
A Computational mechanistic study on the Ni-Catalyzed Asymmetric Alkynyl Propyl Hydroxyaminations: Origin of Enantioselectivity and Further Rational Design DOI
Yuqing Huang,

Manman Zhu,

Shuqi Zhang

и другие.

New Journal of Chemistry, Год журнала: 2024, Номер 48(28), С. 12565 - 12574

Опубликована: Янв. 1, 2024

DFT calculations were conduct to elucidate the catalytic mechanism of target asymmetric propargylic substitution (APS) reaction. Moreover, we rationally designed a more efficient axial chiral phosphine ligand for APS

Язык: Английский

Процитировано

0
Stereoselective Synthesis of acyclic (Z)-3-Haloallylamines via a Multicomponent Reaction of Propargylic Alcohols, TMSX and Sulfonamides DOI
Shuai He, Lijuan Wu, Yan Yin

и другие.

Tetrahedron, Год журнала: 2024, Номер 163, С. 134146 - 134146

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

0