Electrochemical Access to Difluoromethyl Groups: An Overview of Scope, Mechanisms, and Challenges

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 6826 - 6851

Опубликована: Апрель 14, 2025

Язык: Английский

Defluorinative Haloalkylation of Unactivated Alkenes Enabled by Dual Photoredox and Copper Catalysis

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13518 - 13529

Опубликована: Сен. 10, 2024

A three-component defluorinative haloalkylation of alkenes with trifluoromethyl compounds and TBAX (X = Cl, Br) via dual photoredox/copper catalysis is reported. The mild conditions are compatible a wide array activated aromatics bearing diverse substituents, various nonactivated terminal internal alkenes, enabling straightforward access to synthetically valuable γ-gem-difluoroalkyl halides high efficiency. Mechanistic studies indicate that the [Cu] complexes not only serve as XAT catalysts but also facilitate SET reduction groups by photocatalysts. Additionally, resulting alkyl halide products can versatile conversion intermediates for synthesis range compounds.

Язык: Английский

BINOLates as potent reducing photocatalysts for inert bond activation and reduction of unsaturated systems

Chem, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский