Infrared-Driven Rapid Quantification of Magnetophoretically Trapped Drug DOI
Vinit Kumar Yadav, Pankaj Pathak,

Preetha Ganguly

и другие.

Journal of Microelectromechanical Systems, Год журнала: 2024, Номер 33(2), С. 127 - 129

Опубликована: Фев. 23, 2024

This work presents a rapid quantification approach for on-chip, trapped magnetic nanoparticle drug conjugate (MD) and tests its in-vitro efficacy using an integrated piezoelectric/ferromagnetic bilayer structure-based magnetoelectric sensor coupled microfluidic device. The MD trapping is accomplished triangular-shaped, patterned permanent magnet elastomer-free, pure NdFeB micro-powder that generates forces up to 0.2 pN on MDs. flushed in local concentration at the outlet well of device, where placed. position varies with change flow rate from 0.01- $0.1 ~\mu \text{l}$ /min. Upon exposure IR (Infrared) irradiation pulses, detects 0.33-0.21 nA current 0- notation="LaTeX">$500 \text{g}$ /ml due pyroelectric effect exhibits remarkable sensitivity (0.33 nA.ml/ notation="LaTeX">$\mu ) response time ( notation="LaTeX">$ < 2\text{s}$ ). [2023-0218]

Язык: Английский

A system for fluid pumping by liquid metal multi-droplets DOI
Liyu Dai, Xiaomin Wu, Huimin Hou

и другие.

Lab on a Chip, Год журнала: 2024, Номер 24(7), С. 1977 - 1986

Опубликована: Янв. 1, 2024

The transportation and control of microfluidics have an important influence on the fields biology, chemistry, medicine. Pump systems based electrocapillary effect room-temperature liquid metal droplets attracted extensive attention. Flow rate is parameter that reflects delivery performance pump systems. In previous studies, cylindrical structures are mostly used to constrain droplet. analysis quantitative description voltage frequency, alternating voltage, direct current bias, solution concentration flow not yet comprehensive. Furthermore, driven by only one droplet, which limits increase in rate. Therefore, a with cuboid structure designed droplet bound pillars, increased more than 200% compared pump. For this structure, mechanism various factors analyzed. To further enhance rate, system multi-droplets proposed. Moreover, expression velocity surface each relationship between number deduced. Finally, potential applying multi-droplet drug analytical chemistry demonstrated. Additionally, core pump, area, modularized, breaks overall structural limitations provides ideas for design.

Язык: Английский

Процитировано

3
Voltage-controlled strain-mediated elliptical micro-magnetic motors for single magnetic bead manipulation DOI
Pankaj Pathak, Vinit Kumar Yadav, Dhiman Mallick

и другие.

Applied Physics Letters, Год журнала: 2025, Номер 126(7)

Опубликована: Фев. 17, 2025

Effective manipulation of magnetic beads (MBs) with dimensions similar to single cells is crucial for advancing clinical and diagnostic technologies. Traditional methods like optical tweezers dielectrophoresis often require complex setups, making them less suitable scalable laboratory-on-a-chip (LOC) systems. While strain-mediated magnetoelectric (ME) micro-motors offer a promising alternative, they are limited by 45° rotation when using planar electrode systems, the complexity multi-electrode systems rotations beyond 45°, lower thermal stability symmetrical ferromagnetic (FM) rings or disks. This work introduces ME-based LOC device that incorporates micro-magnetic motors, utilizing shape-anisotropic FM elliptical on ferroelectric substrate achieve MB up 90° experimentally simple system. The inherent high enables this without need designs. Micromagnetic simulations employed identify optimal ring structures generate localized stray fields necessary trapping rotating MBs. optimized concentrations flow rates demonstrated 40% capture probability. Under an applied electric field 0.8 MV/m, 90o achieved 1.5 μm wide ring, closely aligning micromagnetic modeling results. ability complicated experimental setup opens possibilities critical biotechnology applications, such as photothermal hyperthermia therapy, where thermally stable, highly FMs in devices could be transformative.

Язык: Английский

Процитировано

0
Nanoparticle and Scalar Mixing of Magnetic Colloids in Microchannels - Prevalence of Kelvin Body Force over Spin-Up Flow DOI Creative Commons
La Zakaria, Faı̈çal Larachi,

Abdelwahid Azzi

и другие.

Chemical Engineering Science, Год журнала: 2025, Номер unknown, С. 121547 - 121547

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Rapid-release reversible bonding of PMMA-based microfluidic devices with PBMA coating DOI

Yusheng Li,

Fan Xu, Jing Liu

и другие.

Biomedical Microdevices, Год журнала: 2023, Номер 26(1)

Опубликована: Дек. 23, 2023

Язык: Английский

Процитировано

5
Infrared-Driven Rapid Quantification of Magnetophoretically Trapped Drug DOI
Vinit Kumar Yadav, Pankaj Pathak,

Preetha Ganguly

и другие.

Journal of Microelectromechanical Systems, Год журнала: 2024, Номер 33(2), С. 127 - 129

Опубликована: Фев. 23, 2024

This work presents a rapid quantification approach for on-chip, trapped magnetic nanoparticle drug conjugate (MD) and tests its in-vitro efficacy using an integrated piezoelectric/ferromagnetic bilayer structure-based magnetoelectric sensor coupled microfluidic device. The MD trapping is accomplished triangular-shaped, patterned permanent magnet elastomer-free, pure NdFeB micro-powder that generates forces up to 0.2 pN on MDs. flushed in local concentration at the outlet well of device, where placed. position varies with change flow rate from 0.01- $0.1 ~\mu \text{l}$ /min. Upon exposure IR (Infrared) irradiation pulses, detects 0.33-0.21 nA current 0- notation="LaTeX">$500 \text{g}$ /ml due pyroelectric effect exhibits remarkable sensitivity (0.33 nA.ml/ notation="LaTeX">$\mu ) response time ( notation="LaTeX">$ < 2\text{s}$ ). [2023-0218]

Язык: Английский

Процитировано

1