Cancers, Год журнала: 2025, Номер 17(4), С. 701 - 701
Опубликована: Фев. 19, 2025
Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects
Язык: Английский
Процитировано
5Much More than Nutrients: The Protective Effects of Nutraceuticals on the Blood–Brain Barrier in Diseases
Nutrients, Год журнала: 2025, Номер 17(5), С. 766 - 766
Опубликована: Фев. 21, 2025
The dysfunction of the blood-brain barrier (BBB) is well described in several diseases, and considered a pathological factor many neurological disorders. This review summarizes most important groups natural compounds, including alkaloids, flavonoids, anthocyanidines, carotenoids, lipids, vitamins that were investigated for their potential protective effects on brain endothelium. penetration these compounds interaction with BBB efflux transporters solute carriers are discussed. cerebrovascular endothelium therapeutic target diseases. In preclinical studies modeling systemic central nervous system nutraceuticals exerted beneficial BBB. vivo, they decreased permeability, edema, astrocyte swelling, morphological changes vessel structure basal lamina. At level endothelial cells, increased cell survival apoptosis. From general functions, angiogenesis levels vasodilating agents demonstrated. elevated integrity by tightened intercellular junctions, expression activity transporters, such as pumps, carriers, metabolic enzymes, shown. Nutraceuticals enhanced antioxidative defense anti-inflammatory at signaling mediating stability activation WNT, PI3K-AKT, NRF2 pathways, inhibition MAPK, JNK, ERK, NF-κB pathways. represent valuable source new potentially molecules to treat diseases protecting
Язык: Английский
Процитировано
2Biosensor-Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics
Sensors, Год журнала: 2024, Номер 24(9), С. 2865 - 2865
Опубликована: Апрель 30, 2024
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as novel strategy for in-depth exploration glioblastoma microenvironment dynamics. In recent years, transformative approach incorporating biosensors into OOC platforms has enabled real-time monitoring analysis cellular behaviors within controlled Conventional in vitro vivo exhibit inherent limitations accurately replicating complex nature progression. addresses existing research gap by pioneering models, providing comprehensive platform investigating The applications this combined studying dynamics are critically scrutinized, emphasizing potential bridge between simplistic conditions. Furthermore, article discusses implications elucidating features microenvironment, encompassing cell migration, proliferation, interactions. By furnishing insights, these significantly contribute unraveling biology glioblastoma, thereby influencing development more accurate diagnostic therapeutic strategies.
Язык: Английский
Процитировано
5Real-time monitoring of a 3D blood-brain barrier model maturation and integrity with a sensorized microfluidic device
Lab on a Chip, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
Язык: Английский
Процитировано
3Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model
Fluids and Barriers of the CNS, Год журнала: 2025, Номер 22(1)
Опубликована: Фев. 19, 2025
Abstract Background Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase permeability vesicular polypeptide nanocarriers containing model cargo across BBB. Our aim was to investigate dopamine- ibuprofen-coupled 3-armed poly( l -glutamic acid) targeted by A-GSH transfer novel human co-culture with induced properties. In addition, protective effect ibuprofen nanoparticles on cytokine-induced damage also measured. Method Drug-coupled were synthetized characterized dynamic light scattering transmission electron microscopy. Cellular effects, uptake, investigated stem cell-based improved properties small molecular cocktail. The immunocytochemistry marker molecules. Nanocarrier uptake in endothelial cells midbrain organoids quantified spectrofluorometry visualized confocal mechanisms cellular explored addition free targeting ligands, endocytic metabolic inhibitors, co-localization intracellular organs, surface charge modification cells. against impedance measurements. Results Targeted nanoformulations both drugs showed elevated time-dependent, active manner via mechanisms. Addition inhibited internalization suggesting crucial role process. A higher measured After crossing BBB, dopamine subsequently entered midbrain-like derived from healthy Parkinson’s disease patient-specific effects damage. Conclusion BBB-targeted coupled therapeutic molecules effectively taken up or showing indicating potential applications nervous system pathologies. Graphical
Язык: Английский
Процитировано
0Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders
Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115561 - 115561
Опубликована: Март 1, 2025
Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development new pharmacological treatments. The location circadian clock machinery in central nervous system makes it challenging to reach molecular targets at therapeutic concentrations. In addition, a timely administration agents is necessary efficiently modulate clock. Thus, use nanoparticles dysfunctions may accelerate clinical translation by addressing these two key challenges: enhancing brain penetration and/or enabling formulation chronodelivery systems. This review describes implications pathologies, reviews potential modulators suggests how nanoparticle-based formulations could improve success. Finally, integration into chronopharmaceutical drug delivery systems will be described.
Язык: Английский
Процитировано
0Recent advances in blood-brain barrier-on-a-chip models
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0A sample-in- result -out microfluidic system for β-thalassemia diagnostics via direct whole blood PCR-reverse dot blot
Clinica Chimica Acta, Год журнала: 2025, Номер 574, С. 120348 - 120348
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0Biological Barrier Models-on-Chips: A Novel Tool for Disease Research and Drug Discovery
Biosensors, Год журнала: 2025, Номер 15(6), С. 338 - 338
Опубликована: Май 26, 2025
The development of alternatives to animal models and traditional cell cultures has led the emergence organ-on-chip (OoC) systems, which replicate organ functions under both physiological pathological conditions. These microfluidic platforms simulate key tissue interfaces—such as tissue–air, tissue–liquid, tissue–tissue interactions—while incorporating biomechanical stimuli closely resemble in vivo environments. This makes OoC systems particularly suitable for modeling biological barriers such skin, placenta, blood–brain barrier, play essential roles maintaining homeostasis. review explores various barrier that can be replicated using technology, discussing integration induced pluripotent stem cells (iPSCs) advance personalized medicine. Additionally, we examine methods assessing formation, including real-time monitoring through integrated sensors, discuss advantages challenges associated with these technologies. potential disease modeling, drug discovery, therapeutic strategies is also highlighted.
Язык: Английский
Процитировано
0Unlocking the Gates: Therapeutic Agents for Noninvasive Drug Delivery Across the Blood-Brain Barrier
Molecular Pharmaceutics, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
The blood-brain barrier (BBB) is a highly selective network of various cell types that acts as filter between the blood and brain parenchyma. Because this, BBB remains major obstacle for drug delivery to central nervous system (CNS). In recent years, there has been focus on developing modifiable platforms, such monoclonal antibodies (mAbs), nanobodies (Nbs), peptides, nanoparticles, both therapeutic agents carriers targeted treat cancers diseases. Methods bypassing can be invasive or noninvasive. Invasive techniques, transient disruption using low pulse electrical fields intracerebroventricular infusion, lack specificity have numerous safety concerns. this review, we will noninvasive transport mechanisms offer high levels biocompatibility, personalization, are regarded generally safer than their counterparts. Modifiable platforms designed noninvasively traverse through one more following pathways: passive diffusion physio-pathologically disrupted BBB, adsorptive-mediated transcytosis, receptor-mediated shuttle-mediated somatic gene transfer. Through understanding pathways, new applications, including Chimeric Antigen Receptors T-cell (CAR-T) therapy, approaches across emerging.
Язык: Английский
Процитировано
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