Analytical Methods, Год журнала: 2024, Номер 16(37), С. 6392 - 6402
Опубликована: Янв. 1, 2024
The One Health perspective highlights the balance needed between antibiotic use and preventing environmental contamination. A newly synthesized MIP sensor offers a revolutionary, miniaturized tool for detecting ENR residues effectively.
Язык: Английский
Chemosensors, Год журнала: 2025, Номер 13(1), С. 26 - 26
Опубликована: Янв. 20, 2025
Cardiac troponin I (cTnI) is a crucial biomarker for the early detection of acute myocardial infarction (AMI), playing significant role in cardiac health assessment. Molecularly imprinted polymers (MIPs) are valued their stability, ease fabrication, reusability, and selectivity. However, using analyte as template can be costly, especially if expensive. In such cases, dummy (DT) with similar chemico-physical properties useful. This study aimed to design DT-MIP cTnI cytochrome c (Cyt c) template, combining computational experimental approaches. Molecular docking identified binding sites on Cyt poly(o-phenylenediamine) (5PoPD) pentamers. Interactions energies were examined all-atom molecular dynamics (MDs) simulations structural interaction fingerprint (SIFt) calculations. A DT-MIP-modified electrode was prepared by electropolymerizing o-PD presence template. Electrochemical techniques monitored electropolymerization, removal, target analyte. The results showed that DT-MIPs exhibited high affinity cTnI, consistent observed MD simulations. satisfactory correlation between validated our model-based approach rational molecularly polymers.
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 6, 2024
Abstract The convergence of tumor epigenetics and molecularly imprinted polymers (MIPs) holds promise in early cancer diagnostics. To the best knowledge, none studies has achieved DNA methylation detection yet using MIPs proposed research will pioneer application for detecting methylation, introducing a novel approach to enhance diagnostic precision.
Язык: Английский
Процитировано
7
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 179, С. 117906 - 117906
Опубликована: Авг. 13, 2024
Since their introduction in the 1970s, molecularly imprinted polymers (MIPs) have been greatly applied analytical chemistry as materials that enhance selectivity of methods. MIPs are mostly explored sample preparation methods, well electrochemical and chemical sensors. In recent years, these has performed on surface metal covalent organic frameworks (MIPs@MOFs COFs). This initiative is geared to improve performance further. The present paper provides a critical review synthesis applications MIPs@MOFs COFs environmental, biological, food analysis while also highlighting major gaps challenges be considered for future explorations. findings this indicate various synthetic routes production materials. aspects more centred selective tools such solid-phase extraction microextraction, sensor technology detection compounds complex matrices.
Язык: Английский
Процитировано
4
Polymer-Plastics Technology and Materials, Год журнала: 2025, Номер unknown, С. 1 - 29
Опубликована: Янв. 12, 2025
This manuscript presents a systematic overview of molecularly imprinted polymer-derived nanocomposites, discussing fundamentals, design categorization, and technological worth, according to the reported literature so far. In this concern, nanocomposites polymers have been synthesized with carbonaceous nanoparticles (graphene, carbon nanotube, fullerene) inorganic (metal/metal oxide, metal organic frameworks). Principal synthesis methods applied for consequential include efficient polymerization tactics, like free radical (bulk/emulsion), electropolymerization, sol-gel, precipitation, imprinting approaches (surface or nanoimprinting). Ensuing macromolecular assemblies nanocomposite hybrid depicted valuable characteristics, counting low price, high surface area, functionalities, microstructural variations, structural stability, facile synthesis, desirable porosity, sensitivity toward other molecules depending upon their precision choice processing technique. Subsequently, worth mentioning combinations nanocarbon/inorganic showed scientific potential water remediation (adsorbent materials), gas/electrochemical sensors, drug delivery, biosensing fields. Although plenty reports revealed design, processing, practical aspects polymers; nonetheless, we note, field needs much future attention precise designs, perfect polymer-nanoparticle assemblies, well-defined techniques/parameters commercial-scale utilizations.
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2025, Номер 287, С. 127592 - 127592
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0
Critical Reviews in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 11, 2025
Due to their natural biocompatibility, cost-effectiveness, and strong interfacial adhesion, biopolymers have highly favorable properties for electrochemical biosensors. this endogenous catecholamine's versatile chemistry, dopamine's oxidation self-polymerization recently attracted considerable interest. Polydopamine (PDA)'s application surface deposition, molecular imprinting, electrochemistry is especially noteworthy. This review aims propose the role of PDA in quantitative applications, evaluate analytical performance, cost, reproducibility, versatility methods developed, standard (bio)analytical platforms. First, parameters that influence polymerization dopamine are discussed. Then, different functionalities its recent applications biosensing purposes reviewed build bioanalytical The discussion concludes with emerging PDA-integrated biosensor Finally, future perspectives improved use
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Accurate monitoring of isopropanol (IPA) levels is crucial for safety in industrial and laboratory settings, as high concentrations can lead to serious health issues. In this study, we present, the first time, a dual-functional antenna sensor capable high-performance IPA gas detection with concentration estimation uninterrupted wireless communication, using optimized molecularly imprinted polymer (MIP)/multiwalled carbon nanotube (MWCNT)-based sensing materials. Comprehensive characterization these materials confirms successful formation homogeneity composites. Furthermore, electrical gas-sensing properties were evaluated functionalized interdigitated electrode (IDE)-based structures, sensitivity, evaluate These IDE which acted impedance-varying components during operation, coupled single-port monopole develop highly sensitive selective while maintaining communication services. The results showed that fabricated platform exhibits strong selectivity, stability at room temperature, effectively distinguishing it from other interference gases. addition, same material, demonstrated antenna-based exhibited higher sensitivity than chemiresistive sensor, achieving limit (18.8 ppm) below thresholds IPA. Moreover, antenna's radiation pattern capabilities remained unaffected, ensuring functionality. Detailed optimization process mechanism novel MIP-based supported by both structural characterizations could serve milestone future studies advancement next-generation sensors.
Язык: Английский
Процитировано
0
iScience, Год журнала: 2025, Номер 28(4), С. 112186 - 112186
Опубликована: Март 10, 2025
Molecular imprinting has become an effective technology in the realm of diagnosing diseases, providing unparalleled specificity and sensitivity. This method is a promising trend current medical research. review examines utilization molecularly imprinted polymers (MIPs) theranostic that integrates diagnostic functionalities for personalized medicine. The present work briefly discusses fundamental concepts molecular how it evolved into versatile platform. Subsequently, MIPs advancement biosensors focused, specifically emphasizing their contribution to detection diagnosis diseases. therapeutic potential MIPs, focusing on targeted drug delivery controlled release systems integration platforms explored through case studies, showcasing technology's ability simultaneously diagnose treat Finally, we address challenges facing discuss future perspectives, this revolutionize next generation.
Язык: Английский
Процитировано
0
Talanta Open, Год журнала: 2025, Номер unknown, С. 100444 - 100444
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Analytical Science Advances, Год журнала: 2025, Номер 6(1)
Опубликована: Апрель 1, 2025
ABSTRACT Cardiac troponin I (cTnI) is a crucial biological macromolecule found in the contractile apparatus of cardiac myocytes, exclusively expressed cardiomyocytes. It released into bloodstream upon tissue injury, serving as vital biomarker for early detection various heart diseases. Despite advancements cTnI diagnostics and cardiovascular disease (CVD) detection, there an ongoing need more effective diagnostic methods innovative approaches. Current CVD diagnosis often relies on clinical signs symptoms, supplemented by molecular imaging (MI) or biomarkers associated with CVD. However, challenges remain regarding reliability, specificity accuracy analyses myocardial infarction, particularly its stages. Emerging nanomaterial systems present promising solutions enhancing tools due to their unique physical chemical properties. Various nanomaterials, such gold nanoparticles, carbon nanotubes, quantum dots, lipids polymer are paving new pathways detection. The science offer exciting opportunities screening. This article provides comprehensive overview these advancements, categorizing research efforts focused both optical electrochemical platforms, thereby contributing evolution screening methodologies addressing critical reliable solutions.
Язык: Английский
Процитировано
0