Applied Materials Today, Год журнала: 2025, Номер 44, С. 102747 - 102747
Опубликована: Май 1, 2025
Язык: Английский
Biomaterials Science, Год журнала: 2024, Номер 12(15), С. 3725 - 3744
Опубликована: Янв. 1, 2024
Herein, we reviewed the recent development in use of MOF materials as a platform for treatment lung cancer.
Язык: Английский
Процитировано
55
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129391 - 129391
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
47
ACS Nano, Год журнала: 2024, Номер 18(35), С. 24327 - 24349
Опубликована: Авг. 22, 2024
A series of progress has been made in the field antimicrobial use nanozymes due to their superior stability and decreased susceptibility drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) complex wound environments low targeting ability catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach bacteria; these exhibit OXD-like GSH-px-like dual enzyme activities produce ROS induce bacterial cuproptosis-like death, thereby eliminating MDRO infections. The results
Язык: Английский
Процитировано
39
Coordination Chemistry Reviews, Год журнала: 2024, Номер 510, С. 215851 - 215851
Опубликована: Апрель 8, 2024
Язык: Английский
Процитировано
23
Small, Год журнала: 2024, Номер 20(47)
Опубликована: Авг. 16, 2024
Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.
Язык: Английский
Процитировано
23
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)
Опубликована: Май 25, 2024
Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.
Язык: Английский
Процитировано
22
RSC Advances, Год журнала: 2023, Номер 13(49), С. 34562 - 34575
Опубликована: Янв. 1, 2023
Metal-organic frameworks (MOFs) and MXenes have demonstrated immense potential for biomedical applications, offering a plethora of advantages. MXenes, in particular, exhibit robust mechanical strength, hydrophilicity, large surface areas, significant light absorption potential, tunable terminations, among other remarkable characteristics. Meanwhile, MOFs possess high porosity area, making them ideal protecting active biomolecules serving as carriers drug delivery, hence their extensive study the field biomedicine. However, akin to (nano)materials, concerns regarding environmental implications persist. The number studies investigating toxicity biocompatibility is growing, albeit further systematic research needed thoroughly understand biosafety issues biological effects prior clinical trials. synthesis often involves use strong acids temperatures, which, if not properly managed, can adverse on environment. Efforts should be made minimize release harmful byproducts ensure proper waste management during production process. In addition, it crucial assess into environment applications. For applications MOFs, several challenges exist. These include fabrication costs, poor selectivity, low capacity, quest stable water-resistant well difficulties recycling/regeneration maintaining chemical/thermal/mechanical stability. Thus, careful consideration associated with utilization vital. addition manufacturing processes, ultimate fate must taken account. While numerous reviews been published this perspective aims shed key issues, urging researchers conduct field. aspects biomedicine are discussed, focusing main outlining future directions.
Язык: Английский
Процитировано
25
Journal of Materials Chemistry A, Год журнала: 2024, Номер 12(32), С. 21230 - 21242
Опубликована: Янв. 1, 2024
In this study, a novel method is investigated for enhancing the electrochemical performance of MOFs, particularly Ni-MOFs, which have encountered challenges in energy storage applications owing to their limited electrical conductivity and stability.
Язык: Английский
Процитировано
17
RSC Medicinal Chemistry, Год журнала: 2024, Номер 15(8), С. 2601 - 2621
Опубликована: Янв. 1, 2024
This perspective reviews recent advances in factors affecting diabetic wound healing patients, the limitations of traditional approaches and application MOF materials healing.
Язык: Английский
Процитировано
11
ACS Omega, Год журнала: 2024, Номер 9(14), С. 16676 - 16686
Опубликована: Апрель 1, 2024
Oxaliplatin (Oxa) is a commonly used chemotherapy drug in the treatment of gastric cancer, but its toxic side effects and resistance after long-term use have seriously limited efficacy. Loading drugs with nanomaterials delivering them to tumor site are common ways overcome above problems. However, as carriers do not therapeutic functions on their own, effect single relatively limited, so there still room for progress related research. Herein, we construct Oxa@Mil-100(Fe) nanocomposites by loading Oxa metal–organic framework (MOF) Mil-100(Fe) high biocompatibility large specific surface area. The pore structure conducive amount drug-loading rate up 27.2%. responsive microenvironment (TME) can release Fe3+ under external stimulation. On one hand, inhibit synthesis DNA induce apoptosis cancer cells. other clear overexpressed glutathione (GSH) TME be reduced Fe2+, inhibiting activity peroxidase 4 (GPX4), leading accumulation intracellular lipid peroxides (LPO), at same time releasing number reactive oxygen species (ROS) through Fenton reaction, inducing ferroptosis With combination ferroptosis, shows good effect, killing cells obvious. In nude mouse model subcutaneous transplantation, significant inhibitory growth, an inhibition nearly 60%. addition excellent antitumor activity, has no obvious or effects. This study provides new idea method combined cancer.
Язык: Английский
Процитировано
10