Small molecule conjugation reduces macrophage uptake and increases in vivo blood circulation of polystyrene nanoparticles DOI
Devyani Yenurkar,

María Julieta Fernández Ruocco,

Pragya

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(2), С. 025017 - 025017

Опубликована: Янв. 12, 2024

Abstract Nanomedicine often failed clinically to show therapeutic efficacy due reduced particle circulation and enhanced capture by the reticuloendothelial system, including liver. Developing novel immunomodulatory surface coating can prevent macrophage increase of nanomedicine, resulting in higher efficiency. Herein, we demonstrate development small molecule (RZA15) with triazole functionality using copper-catalyzed click chemistry conjugate onto spherical polystyrene nanoparticles (NPs) amide coupling reactions, achieving blood lesser uptake nanoconjugates (NCs). In this work, evaluated effectiveness RZA15 for NPs 100 nm size, which is commonly utilized various drug delivery applications, compared poly(ethylene)glycol coatings. Several NC formulations were analyzed vitro normal cells cell viability cellular studies. studies demonstrated NCs following coating. Finally, vivo , blood-circulation, pharmacokinetics, biodistribution performed C57BL/6J mouse model that endorsed substantial role reducing liver spleen results extended blood. Coating molecules severely enhance potential effects nanomedicine at lower doses near future.

Язык: Английский

Nanostructures For Cancer Therapeutics And Diagnostics: Recent Advances And Future Outlook DOI
Sarra El-Abed,

Abdelrahman Sheirf,

Mohammad Daud Ali

и другие.

Radiation Physics and Chemistry, Год журнала: 2024, Номер 226, С. 112295 - 112295

Опубликована: Окт. 15, 2024

Язык: Английский

Процитировано

1
Small molecule conjugation reduces macrophage uptake and increases in vivo blood circulation of polystyrene nanoparticles DOI
Devyani Yenurkar,

María Julieta Fernández Ruocco,

Pragya

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(2), С. 025017 - 025017

Опубликована: Янв. 12, 2024

Abstract Nanomedicine often failed clinically to show therapeutic efficacy due reduced particle circulation and enhanced capture by the reticuloendothelial system, including liver. Developing novel immunomodulatory surface coating can prevent macrophage increase of nanomedicine, resulting in higher efficiency. Herein, we demonstrate development small molecule (RZA15) with triazole functionality using copper-catalyzed click chemistry conjugate onto spherical polystyrene nanoparticles (NPs) amide coupling reactions, achieving blood lesser uptake nanoconjugates (NCs). In this work, evaluated effectiveness RZA15 for NPs 100 nm size, which is commonly utilized various drug delivery applications, compared poly(ethylene)glycol coatings. Several NC formulations were analyzed vitro normal cells cell viability cellular studies. studies demonstrated NCs following coating. Finally, vivo , blood-circulation, pharmacokinetics, biodistribution performed C57BL/6J mouse model that endorsed substantial role reducing liver spleen results extended blood. Coating molecules severely enhance potential effects nanomedicine at lower doses near future.

Язык: Английский

Процитировано

0