BioNanoScience, Год журнала: 2024, Номер 14(3), С. 2817 - 2828
Опубликована: Авг. 9, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 483, С. 149040 - 149040
Опубликована: Янв. 23, 2024
Among metal-based nanomaterials, Copper-based nanomaterials (Cu-BNMs) have become a research hotspot in the biomedical field due to their good biocompatibility and unique properties. However, there are fewer systematic summaries of copper-based especially synthesis Cu-BNMs. As for applications, Cu-BNMs been widely used fields antimicrobial, imaging, therapeutics, showing excellent promising Herein, this review firstly introduces classification various methods synthesizing through both top-down bottom-up types. Then, applications within three tumor therapy classified summarized. Finally, challenges faced application future development c discussed provide basic information illustrations
Язык: Английский
Процитировано
9
Frontiers in Microbiology, Год журнала: 2025, Номер 15
Опубликована: Янв. 9, 2025
A significant global health crisis is predicted to emerge due antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic necessitates continuous therapeutic innovation as conventional treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative synthetic antibiotics. This review presents bacterial mechanisms, nanocarriers for drug delivery, plant-based nanoformulations, particularly nanoantibiotics (nAbts). Green synthesis of nanoparticles has emerged revolutionary approach, it enhances the effectiveness, specificity, transport encapsulated antimicrobials. In addition minimizing systemic side effects, these can maximize impact delivering antimicrobials directly infection site. Furthermore, combining two or more antibiotics within often exhibits synergistic enhancing effectiveness against drug-resistant bacteria. Antimicrobial agents are routinely obtained from secondary metabolites plants, including essential oils, phenols, polyphenols, alkaloids, others. Integrating antibacterial antibiotics, assisted suitable codelivery, potential solution addressing resistance. increasing their boosting immune system, this approach provides safer effective method tackling future infections.
Язык: Английский
Процитировано
1
Bacteria, Год журнала: 2024, Номер 3(2), С. 76 - 98
Опубликована: Апрель 16, 2024
The current healthcare environment is at risk due to the facilitated transmission and empowerment of ESKAPE pathogens, comprising Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species. These pathogens have posed significant challenges global public health threat has only amplified over time. multidrug-resistant bacteria become adept escaping effects conventional antibiotics utilized, leading severe healthcare-associated infections compromising immunocompromised patient outcomes a greater extent. impact evident in rapidly rising rates treatment failures, increased mortality, elevated costs. To combat this looming crisis, diverse strategies been adopted, ranging from development novel antimicrobial agents combination therapies implementation stringent infection control measures. Additionally, there growing emphasis on promoting stewardship programs optimize use existing reduce selective pressure driving evolution resistance. While progress made some extent, rapid adaptability these enhancement resistance mechanisms proves be major hurdle yet crossed by professionals. In viewpoint, impending heralded proliferation need for concerted effort via international collaborations assurance effective sustainable solutions, are explored. curb possibility outbreaks future safeguard health, better preparation awareness defense should given paramount importance.
Язык: Английский
Процитировано
5
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.
Язык: Английский
Процитировано
0
Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107495 - 107495
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106064 - 106064
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114217 - 114217
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Lipopeptide-inspired, short peptide amphiphile-meropenem nanostructures enhance antibiotic efficacy, increase local concentration, reduce dosages, and minimize cytotoxicity, enabling efficient delivery to combat drug-resistant infections.
Язык: Английский
Процитировано
0
Microorganisms, Год журнала: 2025, Номер 13(4), С. 722 - 722
Опубликована: Март 24, 2025
Multidrug-resistant tuberculosis (MDR-TB) is a significant public health challenge globally, exacerbated by the limited efficacy of existing therapeutic approaches, prolonged treatment duration, and severe side effects. As drug resistance continues to emerge, innovative delivery systems strategies are critical combating this crisis. This review highlights molecular mechanisms underlying drugs in Mycobacterium tuberculosis, such as genetic mutation, efflux pump activity, biofilm formation, contributing persistence difficulty eradicating MDR-TB. Current options, including second-line drugs, offer effectiveness, prompting need for innovation advanced therapies systems. The progression discovery has resulted approval therapeutics, bedaquiline delamanid, amongst other promising candidates under investigation. However, overcoming limitations traditional remains challenge. Nanotechnology emerged solution, with nanoparticle-based offering improved bioavailability targeted controlled release delivery, particularly pulmonary targeting intracellular macrophages. Furthermore, development inhalable formulations potential nanomedicines bypass presents novel approach enhancing efficacy. Moreover, adjunctive therapies, immune modulation host-directed being explored improve outcomes. Immunotherapies, cytokine TB vaccines, complementary use antibiotics Personalized medicine leveraging genomic profiling both pathogen host, promise optimizing regimens minimizing resistance. underscores importance multidisciplinary combining discovery, system development, address complexities treating Continued innovation, global collaboration, diagnostics essential developing practical, accessible, affordable treatments
Язык: Английский
Процитировано
0
PeerJ, Год журнала: 2025, Номер 13, С. e19199 - e19199
Опубликована: Апрель 8, 2025
Fungal infections present an increasing global health challenge, with a substantial annual mortality rate of 1.6 million deaths each year in certain situations. The emergence antifungal resistance has further complicated treatment strategies, underscoring the urgent need for novel therapeutic approaches. This review explores recent advances nanoparticle-based therapies targeting fungal infections, emphasizing their unique potential to enhance drug solubility, bioavailability, and targeted delivery. Nanoparticles offer ability penetrate biological barriers, improve stability, act as direct agents by disrupting cell walls generating reactive oxygen species. Despite promising applications, challenges such toxicity, scalability production, controlled release remain. Future research should focus on optimizing nanoparticle properties, evaluating long-term safety profiles, developing environmentally sustainable synthesis methods, exploring synergistic approaches existing drugs. Nanotechnology offers transformative opportunity management diseases, paving way more effective treatments.
Язык: Английский
Процитировано
0