Utilizing perhalopyridine-based alkynes as suitable precursors for the synthesis of novel poly(1,2,3-triazolyl)-substituted perhalopyridines DOI Creative Commons

Fereshteh Khorasani,

Reza Ranjbar‐Karimi, Kazem Mohammadiannejad

и другие.

RSC Advances, Год журнала: 2024, Номер 14(42), С. 30873 - 30885

Опубликована: Янв. 1, 2024

A novel series of poly(1,2,3-triazolyl)-substituted perhalopyridines were synthesized under ultrasonic irradiation. We also developed an effective method for the preparation ((1,2,3-triazol-4-yl)methoxy)-3,4,5,6-tetrachloropyridines.

Язык: Английский

Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Antioxidant Activities DOI

Mohamed Ahmed Mahmoud Abdel Reheim,

Basma Ghazal, Sayeda A. Abdelhamid

и другие.

Drug Development Research, Год журнала: 2024, Номер 85(8)

Опубликована: Дек. 1, 2024

ABSTRACT The design and synthesis of unique two series fluorinated sulfonamides 3a‐f 5a‐g utilizing nucleophilic aromatic substitution reactions tetrafluorophthalonitrile 1 with various 2 under a variety different conditions were the key goals current research. chemical composition generated products has been investigated via mass spectroscopy, HNMR, 13 CNMR, infrared, elemental analyzes. Antimicrobial studies conducted in vitro to evaluate activity all new synthesized compounds against resistant strains. first showed high potency very low concentrations. All studied DPPH Radical Scavenging Activity other even molar ratio. In silico molecular docking was used investigate potential binding pathways for receptors: dihydroprotien synthase protein (ID Code: 1AJ0) as an antibacterial EGFR WT co‐crystallized erlotinib [PDB ID code 1m17]. Furthermore, good ADME predictions Lipinski rule five demonstrated that recently had drug‐likeness qualities when physicochemical parameter most powerful novel candidates determined. Moreover, DFT/B3LYP method functionalized 6‐31G (d, p) basis set employed calculate quantum parameters, MEP analysis, HUMO, LUMO.

Язык: Английский

Процитировано

1
Synthesis of novel triarylmethane derivatives containing a trichloropyrimidine moiety DOI

Fatemeh Rezazadeh‐Jabalbarezi,

Reza Ranjbar‐Karimi, Kazem Mohammadiannejad

и другие.

Journal of the Iranian Chemical Society, Год журнала: 2023, Номер 20(12), С. 2917 - 2922

Опубликована: Окт. 16, 2023

Язык: Английский

Процитировано

2
Synthesis of acyclic triarylmethane-based compounds containing perfluoropyridine subunits using 4,4′-(p-tolylmethylene)bis(2,6-dimethylphenol) as a flexible spacer DOI
Zahra Vari, Reza Ranjbar‐Karimi, Kazem Mohammadiannejad

и другие.

Journal of Molecular Structure, Год журнала: 2023, Номер 1302, С. 137360 - 137360

Опубликована: Дек. 21, 2023

Язык: Английский

Процитировано

1
Utilizing perhalopyridine-based alkynes as suitable precursors for the synthesis of novel poly(1,2,3-triazolyl)-substituted perhalopyridines DOI Creative Commons

Fereshteh Khorasani,

Reza Ranjbar‐Karimi, Kazem Mohammadiannejad

и другие.

RSC Advances, Год журнала: 2024, Номер 14(42), С. 30873 - 30885

Опубликована: Янв. 1, 2024

A novel series of poly(1,2,3-triazolyl)-substituted perhalopyridines were synthesized under ultrasonic irradiation. We also developed an effective method for the preparation ((1,2,3-triazol-4-yl)methoxy)-3,4,5,6-tetrachloropyridines.

Язык: Английский

Процитировано

0