Copper/gold-modified porphyrinic metal–organic frameworks nanoprobes for enhanced photodynamic/chemodynamic therapy

Chemical Engineering Journal, Год журнала: 2023, Номер 474, С. 145485 - 145485

Опубликована: Авг. 19, 2023

Язык: Английский

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A metal-organic framework (MOF) built on surface-modified Cu nanoparticles eliminates tumors via multiple cascading synergistic therapeutic effects

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 298 - 312

Опубликована: Фев. 9, 2024

Язык: Английский

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Tumor Microenvironment-Activated In Situ Synthesis of Peroxynitrite for Enhanced Chemodynamic Therapy

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Chemodynamic therapy (CDT) can induce cancer cell death through hydroxyl radicals (·OH) generated from Fenton or Fenton-like reactions. Compared with traditional therapies, CDT effectively overcomes inevitable drug resistance and exhibits low side effects. However, clinical application still faces challenges, primarily due to insufficient ·OH generation the short-lifetime of in vivo. To address these we developed a peroxynitrite (ONOO

Язык: Английский

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Tumor cells are under siege from all sides: Tumor Cell-Mimic Metal−Organic framework nanoparticles triggering Cuproptosis/Ferroptosis/Apoptosis for Chemo-Chemodynamic-Photothermal-Immunological synergistic antitumor therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 149640 - 149640

Опубликована: Фев. 13, 2024

Язык: Английский

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Multivalence Manganese Mediated Dual ROS Generator for Augmented Chemodynamic Therapy and Activated Antitumor Immunogenic Responses

ACS Materials Letters, Год журнала: 2024, Номер 6(3), С. 885 - 895

Опубликована: Фев. 8, 2024

The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types efficiency generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT ICD. multivalence state Mn ions authorizes MnPt simultaneously generate hydroxyl radical singlet under high H2O2 acid condition, which obviously increases ROS. Significantly, mild photothermal conversion enzyme-like activity endow regulate tumor microenvironment elevate operating rate, further increasing in vitro/vivo. Moreover, exaltation both significantly enhances immunogenicity initiates immune response limit metastases. This study provides practical strategy accurate diagnosis efficient tumors.

Язык: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Год журнала: 2024, Номер 57, С. 102386 - 102386

Опубликована: Июль 13, 2024

Язык: Английский

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Application and prospect of Cu-based metal-organic frameworks in tumor therapy

Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139984 - 139984

Опубликована: Сен. 11, 2024

Язык: Английский

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Glutathione depletion-based pH-responsive injectable hydrogels for synergistic treatment of colon tumor

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139557 - 139557

Опубликована: Янв. 6, 2025

Язык: Английский

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Discovery of mitochondrion-targeting copper(ii)-plumbagin and -bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity

Dalton Transactions, Год журнала: 2024, Номер 53(7), С. 3244 - 3253

Опубликована: Янв. 1, 2024

Four complexes (Cu1–Cu4) that consume glutathione (GSH) were synthesized as mitochondrion-targeting antitumor agents with enhanced chemodynamic therapy (CDT),exhibiting strong anti-tumor activity both in vitro and vivo .

Язык: Английский

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A copper-loaded self-assembled nanoparticle for disturbing the tumor redox balance and triple anti-tumor therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(14), С. 3509 - 3520

Опубликована: Янв. 1, 2024

Both chemodynamic therapy and photodynamic therapy, based on the production of reactive oxygen (ROS), have excellent potential in cancer therapy. However, abnormal redox homeostasis tumor cells, especially overexpressed glutathione (GSH) could scavenge ROS reduce anti-tumor efficiency. Therefore, it is essential to develop a simple effective tumor-specific drug delivery system for modulating microenvironment (TME) achieving synergistic at site. In this study, self-assembled nanoparticles (named CDZP NPs) were developed using copper ion (Cu

Язык: Английский

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