Developing
clinically
meaningful
nanomedicines
for
cancer
therapy
requires
the
drugs
to
be
effective,
safe,
simple,
cheap,
and
easy
store.
In
present
work,
we
report
that
a
simple
cationic
Fe(III)-rich
salt
of
[FeIIICl(TMPPH2)][FeIIICl4]2
(Fe-TMPP)
exhibits
superior
anticancer
performance
toward
broad
spectrum
cell
lines,
including
breast,
colorectal
cancer,
liver,
pancreatic,
prostate,
gastric
cancers,
with
half
maximal
inhibitory
concentration
(IC50)
values
in
range
0.098−3.97
μM
(0.066−2.68
μg
mL−1),
comparable
best-reported
medicines.
Fe-TMPP
can
forms
stand-alone
nanoparticles
water
without
need
extra
surface
modification
or
organic-solvent-assisted
antisolvent
precipitation.
Critically,
is
TME-responsive
(TME
=
tumor
microenvironment),
only
elicit
its
function
TME
overexpressed
H2O2,
converting
H2O2
cytotoxic
•OH
oxidize
phospholipid
membrane,
causing
ferroptosis,
programmed
death
process
cells.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Immunogenic
cell
death
(ICD)-mediated
immunization
strategies
have
great
potential
against
breast
cancer.
However,
traditional
neglect
the
increase
in
immunosuppressive
metabolite,
adenosine
(ADO),
during
ICD,
leading
to
insufficient
therapeutic
outcomes.
In
this
study,
it
is
found
that
A2A
receptor
(A2AR)
significantly
expressed
cancer
and
positively
associated
with
regulatory
T
(Treg)
cells.
Herein,
a
strategy
combining
Fe/Mo-based
lipid
peroxidation
(LPO)
nanoamplifiers
A2AR
blockade
reported
maximize
ICD-mediated
anti-tumor
immunity.
This
LPO
nanoamplifier
causes
explosion
by
Fe
(II)-mediated
Fenton
reaction
Mo(V)-mediated
Russell
mechanism.
Subsequently,
elicits
ICD
magnification
of
tumor
cells
inducing
multiple
regulated
patterns
ferroptosis,
apoptosis,
necroptosis.
Additionally,
antagonist
(SCH58261),
an
immunometabolic
checkpoint
blocker,
relieve
ADO-related
immunosuppression,
amplify
immunological
effects,
elicit
immune
memory
responses.
robust
immunity
observed
primary,
distant,
pulmonary
metastatic,
recurrent
tumors.
study
provides
novel
for
optimizing
immunotherapy
highlights
benefits
enhance
immunotherapy.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 3, 2025
Malignant
pleural
effusion
(MPE),
persistently
generated
by
thorax
tumor
cells
at
the
advanced
stage,
remains
a
major
challenge
for
cancer
therapy.
Herein,
we
develop
an
ultra-sensitive
piezoelectric
nano-system
doping
ytterbium
in
metal-organic
framework
(O3P@LPYU),
which
can
be
triggered
physiological
intrapleural
pressure
during
breath.
Under
gently
alterative
pressure,
nanoparticles
with
notable
peroxidase-like
activity
effectively
produce
burst
of
reactive
oxygen
species
and
induce
immunogenic
cell
death
catalysis
carried
ozone
as
well
peroxide
interstitial
fluid.
A
clear
sustained
biodistribution
is
observed
tumors
upon
administration
particle.
Remarkably,
due
to
abundant
substrates
oxygen-rich
environment
cavity,
O3P@LPYU
particle
provides
potent
reduction
MPE
volume
durable
inhibition
growth
thorax.
Our
work
not
only
develops
bio-responsive
nano-system,
but
also
strategy
persistent
suppression
clinics.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 7, 2024
Cardiovascular
diseases
(CVDs)
are
multifactorial
chronic
and
have
the
highest
rates
of
morbidity
mortality
worldwide.
The
ubiquitin-proteasome
system
(UPS)
plays
a
crucial
role
in
posttranslational
modification
quality
control
proteins,
maintaining
intracellular
homeostasis
via
degradation
misfolded,
short-lived,
or
nonfunctional
regulatory
proteins.
Noncoding
RNAs
(ncRNAs,
such
as
microRNAs,
long
noncoding
RNAs,
circular
small
interfering
RNAs)
serve
epigenetic
factors
directly
indirectly
participate
various
physiological
pathological
processes.
NcRNAs
that
regulate
ubiquitination
regulated
by
UPS
involved
execution
target
protein
stability.
cross-linked
relationship
between
UPS,
ncRNAs
CVDs
has
drawn
researchers'
attention.
Herein,
we
provide
an
update
on
recent
developments
perspectives
how
crosstalk
affects
mechanisms
CVDs,
particularly
myocardial
ischemia/reperfusion
injury,
infarction,
cardiomyopathy,
heart
failure,
atherosclerosis,
hypertension,
ischemic
stroke.
In
addition,
further
envision
RNA
interference
ncRNA
mimics
inhibitors
targeting
can
potentially
be
used
therapeutic
tools
strategies.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(10)
Опубликована: Апрель 2, 2024
Abstract
Herein,
we
report
a
rare
example
of
cationic
three‐dimensional
(3D)
metal‐organic
framework
(MOF)
[Cu
5
Cl
3
(TMPP)]Cl
⋅
x
Sol
(denoted
as
Cu−TMPP
;
H
2
TMPP=
meso
‐tetrakis
(6‐methylpyridin‐3‐yl)
porphyrin;
Sol=encapsulated
solvates)
supported
by
8
6
]
10+
cluster
secondary
building
units
(SBUs)
wherein
the
eight
faces
−
‐based
octahedron
are
capped
Cu
2+
.
Surface‐area
analysis
indicated
that
features
mesoporous
structure
and
its
solvate‐like
counterions
can
be
exchanged
BF
4
,
PF
NO
The
polyvinylpyrrolidone
(PVP)
coated
Cu−TMPP−PVP
)
demonstrated
good
ROS
generating
ability,
producing
⋅OH
in
absence
light
(peroxidase‐like
activity)
1
O
on
irradiation
(650
nm;
25
mW
cm
−2
).
This
work
highlights
potential
functional
carrier
anionic
guests
such
drugs,
for
combination
therapy
cancer
other
diseases.
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2495 - 2495
Опубликована: Май 24, 2024
Developing
clinically
meaningful
nanomedicines
for
cancer
therapy
requires
the
drugs
to
be
effective,
safe,
simple,
cheap,
and
easy
store.
In
present
work,
we
report
that
a
simple
cationic
Fe(III)-rich
salt
of
[Fe
