Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitory Effect of Sonodynamic Therapy against Hepatocellular Carcinoma DOI Creative Commons

Huajing Yang,

Yunfeng Qu,

Yuhang Tian

и другие.

ACS Omega, Год журнала: 2024, Номер 9(52), С. 51253 - 51263

Опубликована: Дек. 18, 2024

Purpose: To assess the anticancer effect of microbubbles (MBs) in combination with sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy (SDT) for vitro and vivo treatment hepatocellular carcinoma (HCC). Methods: HepG2 cells were used experiments. Reactive oxygen species (ROS) production was detected using 2′,7′-dichlorodihydrofluorescein diacetate singlet sensor green solution, respectively. Cytotoxicity evaluated a Cell Counting Kit 8 assay calcein AM/PI double-staining method. Annexin V-FITC/PI staining employed to analyze rate cell apoptosis. surface calreticulin exposure, high mobility group box 1 release, adenosine triphosphate secretion measured detect immunogenic death (ICD). The further assessed Hepa1–6 tumor-bearing mice. Results: Compared SDT alone, ROS MBs + enhanced 1.2-fold (p < 0.0001). cytotoxic DVDMS-mediated on concentration-dependent, additional application increased cytotoxicity. Additionally, augmented SDT-induced apoptosis from 33.26 ± 13.48 72.95 7.95% 0.01). Notably, our results demonstrated that can enhance ICD. In experiments, combined significantly reduced tumor volume, negligible differences mouse body weight. Furthermore, effectively tissue destruction. Conclusion: present study indicates markedly improve effects HCC.

Язык: Английский

The functions and mechanisms of post-translational modification in protein regulators of RNA methylation: Current status and future perspectives DOI
Youming Chen,

Zuli Jiang,

Ying Yang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126773 - 126773

Опубликована: Сен. 9, 2023

Язык: Английский

Процитировано

27

A metal-organic framework (MOF) built on surface-modified Cu nanoparticles eliminates tumors via multiple cascading synergistic therapeutic effects DOI
Guanghui An, Heming Zheng, Lianshan Guo

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 298 - 312

Опубликована: Фев. 9, 2024

Язык: Английский

Процитировано

16

Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Язык: Английский

Процитировано

12

Recent advances in sonodynamic therapy strategies for pancreatic cancer DOI
Peng Cheng,

Shuai Ming,

Wei Cao

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(1)

Опубликована: Янв. 1, 2024

Pancreatic cancer, a prevalent malignancy of the digestive system, has poor 5-year survival rate around 10%. Although numerous minimally invasive alternative treatments, including photothermal therapy and photodynamic therapy, have shown effectiveness compared with traditional surgical procedures, radiotherapy, chemotherapy. However, application these treatments is constrained by their depth penetration, making it challenging to treat pancreatic cancer situated deep within tissue. Sonodynamic (SDT) emerged as promising method that particularly potent against deep-seated tumors such cancer. unique characteristics dense surrounding matrix, high reductivity, hypoxic tumor microenvironment, impede efficient SDT. Thus, guide evolution SDT for this review addresses challenges, examines current strategies effective enhancement investigates potential future advances boost clinical applicability. This article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease.

Язык: Английский

Процитировано

7

Blocking Metallothionein-2 Expression by Copper-Doped Carbon Dots Induces Cellular Antioxidant System Collapse for Antitumor Therapy DOI
Kexuan Liu, Xinchen Liu,

Linlin Wen

и другие.

Nano Letters, Год журнала: 2024, Номер 24(34), С. 10699 - 10709

Опубликована: Авг. 14, 2024

The insufficient antioxidant reserves in tumor cells play a critical role reactive oxygen species (ROS)-mediated therapeutics. Metallothionein-2 (MT-2), an intracellular cysteine-rich protein renowned for its potent properties, is intricately involved development and correlates with poor prognosis. Consequently, MT-2 emerges as promising target therapy. Herein, we present the of copper-doped carbon dots (Cu-CDs) to compromise delicate cells. These Cu-CDs high accumulation prolonged body retention can effectively suppress growth by inducing oxidative stress. Transcriptome sequencing unveils significant decrease expression within

Язык: Английский

Процитировано

7

Rational Design of Single‐Atom Nanozymes for Combination Cancer Immunotherapy DOI Open Access

Hanchao Lin,

Yonghui Gao,

Le Zhu

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Remodeling of the tumor immune microenvironment and enhancement antitumor responses are necessary to overcome immunotherapy resistance in tumors. However, heterogeneity complexity evasion mechanisms pose significant therapeutic challenges. Nanozymes exhibit enzyme‐like characteristics unique nanomaterial properties, showing potential for therapy. design effective nanozymes remains complex, inefficient, functionally limited. Therefore, this study, a novel strategy combining rationally designed single‐atom (SAzymes) with checkpoint blockade (ICB) therapy is established. Molybdenum SAzymes supported on graphitic carbon nitride (Mo SAs) constructed using 25 transition metal candidates from 4th 6th periods based high‐throughput calculations optimal piezoelectric‐enhanced multienzyme‐like activities. Upon activation by ultrasound, Mo SAs exerted potent effects against ICB‐resistant tumors remodeled inducing immunogenic cell death, alleviating hypoxia, modulating chemokine expression Combination anti‐programmed death protein‐1 antibodies further enhanced their efficacy, highlighting treat

Язык: Английский

Процитировано

1

Albumin/Magnetite/Hematoporphyrin Composite Nanoparticles as Drug Carriers for the Photodynamic Therapy of Oral Squamous Cell Carcinoma DOI
Andong Liu,

Haining Xia,

Hao Yang

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

1

Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment DOI Creative Commons
Xiaofeng Dai, Yilin Dai,

Yan Zheng

и другие.

RSC Advances, Год журнала: 2024, Номер 14(40), С. 29039 - 29051

Опубликована: Янв. 1, 2024

The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and properties such as biocompatibility, chemical stability, high susceptibility. However, several critical issues still remain that significantly halted the clinical translation these nanomaterials relatively low therapeutic efficacy, hyperthermia resistance, biosafety concerns. To identify innovative approaches possibly creating synergies with MNPs resolve or mitigate problems, we delineated anti-cancer existing onco-therapeutic portfolios, based on which proposed cold atmospheric plasma (CAP) be a possible synergizer by enhancing free radical generation, reducing preventing MNP aggregation, functioning an light source for magnetothermal- photo-therapies. Our insights facilitating role CAP in translating use may inspire fresh research directions that, once actualized, gain mutual benefits from both.

Язык: Английский

Процитировано

3

Encapsulation of astaxanthin in OSA-starch based amorphous solid dispersions with HPMCAS-HF/Soluplus® as effective recrystallization inhibitor DOI

Yinglan Li,

Qipeng Wei,

Jianshuo Su

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135421 - 135421

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3

Targeted Drug Delivery with Photoluminescent Emitters: Applications in Diagnostic DOI
Abayomi Bamisaye, Nelson Oshogwue Etafo, Muyideen Olaitan Bamidele

и другие.

Engineering materials, Год журнала: 2025, Номер unknown, С. 75 - 119

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0