Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(1)
Опубликована: Янв. 1, 2024
Pancreatic
cancer,
a
prevalent
malignancy
of
the
digestive
system,
has
poor
5-year
survival
rate
around
10%.
Although
numerous
minimally
invasive
alternative
treatments,
including
photothermal
therapy
and
photodynamic
therapy,
have
shown
effectiveness
compared
with
traditional
surgical
procedures,
radiotherapy,
chemotherapy.
However,
application
these
treatments
is
constrained
by
their
depth
penetration,
making
it
challenging
to
treat
pancreatic
cancer
situated
deep
within
tissue.
Sonodynamic
(SDT)
emerged
as
promising
method
that
particularly
potent
against
deep-seated
tumors
such
cancer.
unique
characteristics
dense
surrounding
matrix,
high
reductivity,
hypoxic
tumor
microenvironment,
impede
efficient
SDT.
Thus,
guide
evolution
SDT
for
this
review
addresses
challenges,
examines
current
strategies
effective
enhancement
investigates
potential
future
advances
boost
clinical
applicability.
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease.
Nano Letters,
Год журнала:
2024,
Номер
24(34), С. 10699 - 10709
Опубликована: Авг. 14, 2024
The
insufficient
antioxidant
reserves
in
tumor
cells
play
a
critical
role
reactive
oxygen
species
(ROS)-mediated
therapeutics.
Metallothionein-2
(MT-2),
an
intracellular
cysteine-rich
protein
renowned
for
its
potent
properties,
is
intricately
involved
development
and
correlates
with
poor
prognosis.
Consequently,
MT-2
emerges
as
promising
target
therapy.
Herein,
we
present
the
of
copper-doped
carbon
dots
(Cu-CDs)
to
compromise
delicate
cells.
These
Cu-CDs
high
accumulation
prolonged
body
retention
can
effectively
suppress
growth
by
inducing
oxidative
stress.
Transcriptome
sequencing
unveils
significant
decrease
expression
within
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Remodeling
of
the
tumor
immune
microenvironment
and
enhancement
antitumor
responses
are
necessary
to
overcome
immunotherapy
resistance
in
tumors.
However,
heterogeneity
complexity
evasion
mechanisms
pose
significant
therapeutic
challenges.
Nanozymes
exhibit
enzyme‐like
characteristics
unique
nanomaterial
properties,
showing
potential
for
therapy.
design
effective
nanozymes
remains
complex,
inefficient,
functionally
limited.
Therefore,
this
study,
a
novel
strategy
combining
rationally
designed
single‐atom
(SAzymes)
with
checkpoint
blockade
(ICB)
therapy
is
established.
Molybdenum
SAzymes
supported
on
graphitic
carbon
nitride
(Mo
SAs)
constructed
using
25
transition
metal
candidates
from
4th
6th
periods
based
high‐throughput
calculations
optimal
piezoelectric‐enhanced
multienzyme‐like
activities.
Upon
activation
by
ultrasound,
Mo
SAs
exerted
potent
effects
against
ICB‐resistant
tumors
remodeled
inducing
immunogenic
cell
death,
alleviating
hypoxia,
modulating
chemokine
expression
Combination
anti‐programmed
death
protein‐1
antibodies
further
enhanced
their
efficacy,
highlighting
treat
RSC Advances,
Год журнала:
2024,
Номер
14(40), С. 29039 - 29051
Опубликована: Янв. 1, 2024
The
biomedical
applications
of
magnetic
nanoparticles
(MNPs)
have
gained
increasing
attention
due
to
their
unique
biological,
chemical,
and
properties
such
as
biocompatibility,
chemical
stability,
high
susceptibility.
However,
several
critical
issues
still
remain
that
significantly
halted
the
clinical
translation
these
nanomaterials
relatively
low
therapeutic
efficacy,
hyperthermia
resistance,
biosafety
concerns.
To
identify
innovative
approaches
possibly
creating
synergies
with
MNPs
resolve
or
mitigate
problems,
we
delineated
anti-cancer
existing
onco-therapeutic
portfolios,
based
on
which
proposed
cold
atmospheric
plasma
(CAP)
be
a
possible
synergizer
by
enhancing
free
radical
generation,
reducing
preventing
MNP
aggregation,
functioning
an
light
source
for
magnetothermal-
photo-therapies.
Our
insights
facilitating
role
CAP
in
translating
use
may
inspire
fresh
research
directions
that,
once
actualized,
gain
mutual
benefits
from
both.
