Опубликована: Янв. 1, 2024
Язык: Английский
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Wearable wound exudate sensors hold great promise for providing dynamic measurements of valuable biomarkers. However, no existing are able to achieve the fully integrated, skin-on, and detection raw oxygen (O2), which is closely related conditions also essential healing. Here, we report a integrated wearable biomimetic microfluidic tracker, capable skin-on sampling, monitoring O2 in addition uric acid, lactate, pH, temperature, wireless control through seamless integration specially designed microfluidic, sensing, electronic modules. We test performance device both bacterium-inoculated uninoculated wounds using mouse models. further assess its potential management healing process infected diabetic controlled experiments local hyperbaric treatment.
Язык: Английский
Процитировано
0
Biosensors and Bioelectronics, Год журнала: 2025, Номер 286, С. 117616 - 117616
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Colloidal nanozymes, enzyme-mimetic nanocatalysts with tunable catalytic activity, are revolutionizing cancer diagnosis and therapy by integrating precision biomedical functionality. Their ability to regulate redox homeostasis, generate reactive oxygen species (ROS), modulate tumor microenvironments provides a foundation for targeted therapeutic interventions, while their intrinsic properties enhance biosensing imaging early detection. However, the rational design of nanozymes remains challenge, particularly in optimizing efficiency, biocompatibility, specificity tumor-selective reactions. This review explores how surface chemistry, interfacial engineering, mechanisms dictate nanozyme stability, interactions biological systems. We critically analyze fundamental peroxidase-like, oxidase-like, catalase-like, superoxide dismutase (SOD)-like reactions driving applications therapy, as well role biosensors, probes, theranostic platforms diagnosis. Additionally, we examine cutting-edge modification strategies, including atomic dispersion, ligand coordination, defect selectivity reduce off-target effects. By catalysis translational applications, this establishes comprehensive framework advancing nanozyme-based diagnostics therapeutics oncology.
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Июнь 3, 2025
Wearable sweat biosensors possess the unique capacity to noninvasively and continually track chemical biomarkers pertinent health assessment illness diagnoses. Personalized monitoring of myo-inositol is crucial in physiological function modulation disease management. However, current methodologies heavily rely on intrusive blood draws/unwieldy analytical laboratory apparatus, hindering their implementation for daily real-time monitoring. Here, we report a skin-interfaced entirely self-contained wearable biosensor (ES-WSMB), which readily allows on-demand extraction at rest via an iontophoresis unit, automated sampling renewal microfluidic analysis calibration with simultaneously collected pH Na+ signal processing/communication intelligent control unit. We tested performance ES-WSMB healthy participants through dose-response metabolic-interference challenges. identify high correlation between plasma experiments that are exquisitely designed. These distinctive features would facilitate precise personalized management functions, disease, beyond.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2