Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
that
uses
photosensitizers
(PSs)
to
generate
cytotoxic
reactive
oxygen
species
(ROS)
under
light,
but
improving
its
efficacy
crucial
for
clinical
applications.
To
address
this,
we
propose
smart
nanoplatform
(P@BAO-DOX)
synergistic
chemo-photodynamic
therapy,
featuring
efficient
PDT,
controllable
drug
release,
and
fluorescence
imaging
guidance.
We
designed
an
aggregation-induced
emission
(AIE)-based
PS
(BAO)
with
effective
ROS
generation
NIR-II
fluorescence.
Additionally,
BAO
as
doxorubicin
(DOX)
chemo
were
encapsulated
in
pH-responsive
nanogels
(PNA)
obtain
P@BAO-DOX
nanogels.
Upon
uptake
by
tumor
cells,
the
nanogel
releases
drugs
acidic
conditions,
leading
cell
death.
White
light
irradiation
further
triggers
produce
substantial
ROS,
enhancing
phototoxicity
chemo-PDT
therapy.
Thus,
nanogels,
nanoplatform,
offer
precise
release
imaging-guided
showing
promise
advancing
treatment.
Nanoscale,
Год журнала:
2024,
Номер
16(17), С. 8573 - 8582
Опубликована: Янв. 1, 2024
Janus
nanoparticles
with
soluble
polyvinylpyrrolidone
patches
located
on
the
insoluble
Eudragit
RL100
sides
were
prepared
using
a
side-by-side
electrospraying
method
and
are
demonstrated
to
provide
biphasic
release
of
paracetamol
in
turn
faster
action
longer
time
periods
blood
drug
concentration
for
therapy.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(16), С. 3807 - 3839
Опубликована: Янв. 1, 2024
This
review
article
explores
the
innovative
field
of
eco-friendly
cyclodextrin-based
coordination
polymers
and
metal-organic
frameworks
(MOFs)
for
transdermal
drug
delivery
in
case
skin
cancer
therapy.
We
critically
examine
significant
advancements
developing
these
nanocarriers,
with
a
focus
on
their
unique
properties
such
as
biocompatibility,
targeted
release,
enhanced
permeability.
These
attributes
are
instrumental
addressing
limitations
inherent
traditional
treatments
represent
paradigm
shift
towards
more
effective
patient-friendly
therapeutic
approaches.
Furthermore,
we
discuss
challenges
faced
optimizing
synthesis
process
large-scale
production
while
ensuring
environmental
sustainability.
The
also
emphasizes
immense
potential
clinical
applications
nanocarriers
therapy,
highlighting
role
facilitating
targeted,
controlled
release
which
minimizes
systemic
side
effects.
Future
could
see
being
customized
to
individual
patient
profiles,
potentially
revolutionizing
personalized
medicine
oncology.
With
further
research
trials,
hold
promise
transforming
landscape
treatment.
this
study,
aim
provide
comprehensive
overview
current
state
outline
future
directions
advancing
development
application
nanocarriers.
Industrial & Engineering Chemistry Research,
Год журнала:
2025,
Номер
64(4), С. 1907 - 1932
Опубликована: Янв. 14, 2025
Metal–organic
frameworks
(MOFs)
have
been
shown
to
be
great
alternatives
traditional
porous
materials
in
various
chemical
applications,
and
they
very
widely
studied
for
biomedical
applications
the
past
decade
specifically
drug
storage.
After
our
review
published
2011
[Keskin
Kızılel,
Ind.
Eng.
Chem.
Res.
2011,
50
(4),
1799–1812,
10.1021/ie101312k],
we
witnessed
a
fast
growth
not
only
number
variety
of
MOFs
but
also
their
usage
across
broad
spectrum
fields.
With
recent
integration
molecular
modeling
data
science
approaches
experimental
studies,
significantly
accelerated
positioning
them
as
pivotal
components
regenerative
medicine,
medical
imaging,
diagnostics.
In
this
review,
visited
diverse
considering
computational
efforts
on
storage
delivery,
bioimaging,
biosensing.
We
focused
underlying
mechanisms
governing
interactions
between
biological
systems
discussed
both
opportunities
challenges
field
highlight
potential
advanced
therapeutics
cancer
neurological
diseases.
Antibiotic
resistance
is
a
growing
global
threat
due
to
antibiotic
overuse
and
limited
treatment
options.
Multidrug-resistant
bacteria,
like
Staphylococcus
aureus
Escherichia
coli,
increase
infection
complexity
mortality.
This
study
explores
nanocomposite
films
of
ZIF-8
nanoparticles
Doxycycline
(Dox)
enhance
antibacterial
efficacy.
In
this
study,
composed
chitosan
(CS)
polyethylene
glycol
(PEG),
incorporating
zeolitic
imidazolate
framework-8
(ZIF-8)
DOX,
were
developed.
These
characterized
by
their
morphological,
mechanical,
antibacterial,
drug-release
properties.
Antibacterial
efficacy
was
evaluated
using
disk
diffusion,
broth
microdilution,
checkerboard
assay
methods
determine
MICs
potential
synergistic
effects.
The
demonstrated
flexibility,
semi-transparency,
yellowish-brown
hue,
with
containing
being
thicker
(79
±
0.2
μm)
than
those
without
(54
0.5
μm).
tensile
strength
enhanced
the
incorporation
ZIF-8,
peaking
at
53.12
MPa
for
CS-PEG-G-10%
DOX-4%
film.
XRD
analysis
confirmed
crystallinity
distinct
peaks
observed
each
material.
drug
release
studies
revealed
an
initial
burst
followed
sustained
release,
higher
rates
in
acidic
environments
compared
neutral
alkaline
media.
film
significantly
activity,
achieving
lowest
MIC
values,
particularly
against
S.
(22.5
mm
inhibition
zone)
E.
coli
(14
zone).
Additionally,
notable
effect
between
DOX
FICI
values
below
0.5.
exhibits
optimal
properties,
positioning
it
as
strong
candidate
developing
effective
treatments
multidrug-resistant
pathogens.
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer
drug
delivery
remains
a
critical
challenge
with
systemic
toxicity,
poor
bioavailability,
and
lack
of
effective
targeting.
Overcoming
these
barriers
is
essential
for
improving
treatment
efficacy
patient
outcomes.
This
review
discusses
current
techniques
that
reshape
cancer
therapy
by
offering
precise,
controlled-release
tailored
to
tumor-specific
features.
Innovations
in
nanotechnology,
immunotherapy,
gene
enable
interventions
at
molecular
cellular
levels.
Radiomics
pathomics
integrate
high-dimensional
data
optimize
diagnostics
planning.
Combination
addresses
the
complexities
tumor
heterogeneity
synergizing
multiple
agents
within
single
therapeutic
framework,
while
peptide-drug
conjugates
enhance
specificity
potency.
Hydrogel-based
systems
microneedle
arrays
offer
localized,
sustained
release,
significantly
However,
clinical
translation
advancements
faces
significant
such
as
resistance,
off-target
effects,
scalability,
cost,
ethical
concerns.
Moreover,
regulatory
economic
feasibility
therapies
highlight
need
innovative
frameworks
make
them
accessible
globally.
Therefore,
there
innovation
cell
therapy,
next-generation
platforms,
personalized
medicine.
focuses
on
recent
over
past
decade,
evaluating
their
limitations
exploring
potential
future
directions
transforming
treatment.
Molecular Systems Design & Engineering,
Год журнала:
2024,
Номер
9(11), С. 1085 - 1106
Опубликована: Янв. 1, 2024
Porous
nanostructures
exhibit
remarkable
nanoplatforms
for
payload
delivery
to
diseased
cells
with
high
loading
capacity,
favorable
release
profiles,
improved
hemocompatibility,
biocompatibility,
and
safe
clearance
after
biodegradation.
