Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol

Nanoscale, Год журнала: 2024, Номер 16(17), С. 8573 - 8582

Опубликована: Янв. 1, 2024

Janus nanoparticles with soluble polyvinylpyrrolidone patches located on the insoluble Eudragit RL100 sides were prepared using a side-by-side electrospraying method and are demonstrated to provide biphasic release of paracetamol in turn faster action longer time periods blood drug concentration for therapy.

Язык: Английский

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Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(16), С. 3807 - 3839

Опубликована: Янв. 1, 2024

This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.

Язык: Английский

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Polydopamine-Coated Zn-MOF-74 Nanocarriers: Versatile Drug Delivery Systems with Enhanced Biocompatibility and Cancer Therapeutic Efficacy

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 13, 2024

Язык: Английский

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Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125295 - 125295

Опубликована: Фев. 1, 2025

Язык: Английский

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Sequential Stimuli‐Response System of Eu‐MOF Isomers

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Abstract Multiple stimuli‐responsive materials hold excellent potential for the next generation smart owing to their unique response external stimuli, providing a powerful impetus development of intelligent optical devices. The behavior common multiple are independent each other, causing lack multiplicity and identification information technology, which is easy decode. Herein, QIPA‐Eu‐1 QIPA‐Eu‐2 isomers were prepared from QIPA EuCl 3 ·6H 2 O in different solvent thermal conditions building sequential stimuli‐response (SSR) system. Solvent‐driven structural transformations into QIPA‐Eu‐3 occurred, along with color change fluorescence emission variation ascribed aggregates. Furthermore, displayed photochromic behaviors. Combining theoretical calculation well‐defined experiments reveal mechanism, it was found that light drove dihedral angles between quinoline nucleus adjacent benzene rings Finally, on basis stimuli‐induced stepwise responsive QIPA‐Eu‐1, logic gate time‐dependent dynamic anti‐counterfeiting pattern successfully constructed. This study provided new perspective design construction SSR system, showed promising fields data transmission encryption.

Язык: Английский

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Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100406 - 100406

Опубликована: Фев. 1, 2025

Язык: Английский

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MXene-reinforced bioactive polymer hydrogels for biomedical applications

APL Materials, Год журнала: 2024, Номер 12(8)

Опубликована: Авг. 1, 2024

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced

Язык: Английский

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Biomedical Applications of Metal–Organic Frameworks Revisited

Industrial & Engineering Chemistry Research, Год журнала: 2025, Номер 64(4), С. 1907 - 1932

Опубликована: Янв. 14, 2025

Metal–organic frameworks (MOFs) have been shown to be great alternatives traditional porous materials in various chemical applications, and they very widely studied for biomedical applications the past decade specifically drug storage. After our review published 2011 [Keskin Kızılel, Ind. Eng. Chem. Res. 2011, 50 (4), 1799–1812, 10.1021/ie101312k], we witnessed a fast growth not only number variety of MOFs but also their usage across broad spectrum fields. With recent integration molecular modeling data science approaches experimental studies, significantly accelerated positioning them as pivotal components regenerative medicine, medical imaging, diagnostics. In this review, visited diverse considering computational efforts on storage delivery, bioimaging, biosensing. We focused underlying mechanisms governing interactions between biological systems discussed both opportunities challenges field highlight potential advanced therapeutics cancer neurological diseases.

Язык: Английский

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Rapid synthesis of CuTA/Cur@ZIF-8 multifunctional drug delivery system towards cancer treatment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136321 - 136321

Опубликована: Фев. 1, 2025

Язык: Английский

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Synergistic antibacterial activity of chitosan-polyethylene glycol nanocomposites films containing ZIF-8 and doxycycline

BMC Biotechnology, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 20, 2025

Antibiotic resistance is a growing global threat due to antibiotic overuse and limited treatment options. Multidrug-resistant bacteria, like Staphylococcus aureus Escherichia coli, increase infection complexity mortality. This study explores nanocomposite films of ZIF-8 nanoparticles Doxycycline (Dox) enhance antibacterial efficacy. In this study, composed chitosan (CS) polyethylene glycol (PEG), incorporating zeolitic imidazolate framework-8 (ZIF-8) DOX, were developed. These characterized by their morphological, mechanical, antibacterial, drug-release properties. Antibacterial efficacy was evaluated using disk diffusion, broth microdilution, checkerboard assay methods determine MICs potential synergistic effects. The demonstrated flexibility, semi-transparency, yellowish-brown hue, with containing being thicker (79 ± 0.2 μm) than those without (54 0.5 μm). tensile strength enhanced the incorporation ZIF-8, peaking at 53.12 MPa for CS-PEG-G-10% DOX-4% film. XRD analysis confirmed crystallinity distinct peaks observed each material. drug release studies revealed an initial burst followed sustained release, higher rates in acidic environments compared neutral alkaline media. film significantly activity, achieving lowest MIC values, particularly against S. (22.5 mm inhibition zone) E. coli (14 zone). Additionally, notable effect between DOX FICI values below 0.5. exhibits optimal properties, positioning it as strong candidate developing effective treatments multidrug-resistant pathogens.

Язык: Английский

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