Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release

Materials, Год журнала: 2025, Номер 18(5), С. 1065 - 1065

Опубликована: Фев. 27, 2025

The increase in life expectancy has led to a rise of musculoskeletal disorders. Calcium phosphate cements (CPCs), thanks some amazing features such as the ability harden vivo, bioactivity, and resorbability, are promising candidates treat these diseases, notwithstanding their poor mechanical properties. We aimed synthesise pure barium- or silicon-doped brushite-based CPCs loaded with piroxicam study effects substitution on physical-chemical pharmaceutical properties before after cement immersion buffer for different time periods. Our results demonstrated that became amorphous hardened cements. dopants did not change brushite structure its lamellar morphology, while both Ba Si additions improved initial Young's modulus compared cement, opposite trend was observed compressive strength. Both strength elastic decreased samples immersed solution non-immersed samples, stabilisation number days increased. After 7 days, whole drug amount released, slower constant kinetic Ba-doped Si-doped ones.

Язык: Английский

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Advancements in nanotechnology for targeted drug delivery in postmenopausal osteoporosis

International Journal of Advanced Academic Studies, Год журнала: 2024, Номер 6(5), С. 32 - 37

Опубликована: Май 1, 2024

Recent advancements in drug delivery systems, particularly those utilizing nanotechnology, offer promising avenues for more effective treatment of osteoporosis, a silent and progressive disease prevalent among postmenopausal women. Nanoparticle-based including liposomes, polymeric nanoparticles, micelles, enable targeted osteoporosis drugs to specific sites the body, such as areas bone loss. This approach enhances concentration at desired site while minimizing systemic exposure, thereby reducing adverse effects. Additionally, nanoparticles can be engineered controlled release, prolonging its therapeutic Surface modification with targeting ligands, like bisphosphonates, further their bone-targeting capabilities, ensuring efficient uptake by cells. Hydrogel-based systems represent another innovative treatment. Hydrogels, loaded drugs, provide sustained release promote regeneration, enhancing potential. Gene therapy, involving genes encoding bone-stimulating factors, offers avenue long-term management underlying molecular mechanisms. Microneedle patches 3D-printed implants minimally invasive customizable methods, patient convenience compliance. Despite these advancements, challenges remain, safety biocompatibility nanomaterials, optimizing efficiency evaluating effects risks associated gene addressing scalability cost-effectiveness advanced systems. However, integrating nanotechnology into has significantly treatment, offering personalized therapies minimized maximized efficacy.

Язык: Английский

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A bone-targeting delivery platform based on mesoporous silica loaded with piR7472 for the treatment of osteoporosis

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(12), С. 106040 - 106040

Опубликована: Ноя. 2, 2024

Язык: Английский

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The critical role of RANKL in gingivitis progression and bone health: A call for targeted therapeutic interventions

International Immunopharmacology, Год журнала: 2024, Номер unknown, С. 113836 - 113836

Опубликована: Дек. 1, 2024

Язык: Английский

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